Brenner and Stevens’ Pharmacology

6th Edition - February 1, 2022
Author: Craig W. Stevens
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 7 5 8 9 8 - 7
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 7 5 8 9 9 - 4

More detailed than an outlined review but less overwhelming than an encyclopedic reference, Brenner and Stevens’ Pharmacology, 6th Edition, focuses on the essential principles you… Read more

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More detailed than an outlined review but less overwhelming than an encyclopedic reference, Brenner and Stevens’ Pharmacology, 6th Edition, focuses on the essential principles you need to know in a concise, easy-to-understand manner. Authored by Craig W. Stevens, PhD, this highly illustrated introductory text helps you learn and retain key information in pharmacology—taking you from course exams and the USMLE Step 1 right through to clinical practice. New and extensively revised content keeps you up to date with the latest pharmacologic mechanisms and applications.

Instructions for online access
Cover image
Title page
Table of Contents
Copyright
Preface
Section I. PRINCIPLES OF PHARMACOLOGY
CHAPTER 1. Introduction to Pharmacology and Drug Names
Pharmacology and Related Sciences
Drug Sources And Preparations
Routes of Drug Administration
Drug Names
Summary of Important Points
CHAPTER 2. Pharmacokinetics or What the Body Does to the Drug
Overview
Drug Absorption
Drug Distribution
Drug Metabolism
Drug Excretion
Quantitative Pharmacokinetics
Single-Dose Pharmacokinetics
Continuous-Dose and Multiple-Dose Kinetics
Summary of Important Points
CHAPTER 3. Pharmacodynamics or What the Drug Does to the Body
Overview
Nature of Drug Receptors
Drug-Receptor Interactions
Dose-Response Relationships
Summary of Important Points
Chapter 4. Drug Development and Drug Safety
Overview
Drug Development
The Investigational New Drug Application
Federal Drug Laws And Regulations
Adverse Effects Of Drugs
Drug Interactions
Factors Affecting Drug Safety And Efficacy
Summary Of Important Points
CHAPTER 5. Toxicology Principles and the Treatment of Poisoning
Overview
Treatment Of Poisoning
Summary Of Important Points
Section II. AUTONOMIC AND NEUROMUSCULAR PHARMACOLOGY
Chapter 6. Parasympathetic, Neuromuscular Pharmacology, and Cholinergic Agonists
Overview
Anatomy And Physiology Of The Peripheral Nervous System
Neurotransmission And Sites Of Drug Action
Acetylcholine Receptors
Acetylcholine Agonists
Summary Of Important Points
Chapter 7. Cholinergic Receptor Antagonists
Overview
Muscarinic Receptor Antagonists
Nicotinic Receptor Antagonists
Summary Of Important Points
Chapter 8. Sympathetic Neuropharmacology and Adrenergic Agonists
Overview
Drugs Affecting Adrenergic Neurotransmission
Adrenoceptor Agonists
Signal Transduction
Classification Of Adrenoceptor Agonists
Summary Of Important Points
Chapter 9. Adrenergic Receptor Antagonists
Overview
α-Adrenoceptor Antagonists
β-Adrenoceptor Antagonists
α- And β-Adrenoceptor Antagonists
Summary Of Important Points
Section III. CARDIOVASCULAR, RENAL, AND HEMATOLOGIC PHARMACOLOGY
CHAPTER 10. Antihypertensive Drugs
Overview
Diuretics
Sympatholytic Drugs
Angiotensin Inhibitors
Vasodilators
The Management of Hypertension
Summary of Important Points
Chapter 11. Antianginal Drugs
Overview
Vasodilators
Beta-Adrenoceptor Antagonists
Other Antianginal Agents
Management of Angina Pectoris
Summary of Important Points
Chapter 12. Drugs for the Treatment of Heart Failure
Overview
Positively Inotropic Drugs
Vasodilators
BETA-Adrenoceptor Antagonists
Aldosterone Antagonists
Diuretics
Management of Heart Failure
Summary of Important Points
CHAPTER 13. Diuretic Drugs
Overview
Nephron Function and Sites of Drug Action
Diuretic Agents
Management of Edema
Summary of Important Points
Chapter 14. Drugs for Cardiac Dysrhythmia
Overveiw
Sodium Channel Blockers
Management of Dysrhythmias
Summary of Important Points
CHAPTER 15. Drugs for Hyperlipidemia
Overview
Drugs For Hypercholesterolemia
Drugs For Familial Hypercholesterolemia and Leptin Deficiency
Summary of Important Points
Chapter 16. Antithrombotic and Thrombolytic Drugs
Overview
Anticoagulant Drugs
Antiplatelet Drugs
Summary of Important Points
CHAPTER 17. Hematopoietic Drugs
Overview
Hematopoietic Drugs
Drugs for Sickle Cell Disease
Summary of Important Points
Section IV. CENTRAL NERVOUS SYSTEM PHARMACOLOGY
Chapter 18. Introduction to Central Nervous System Pharmacology
Overview
Neurotransmission in the Central Nervous System
Mechanisms of Drug Action
Neuronal Systems in the Central Nervous System
Summary of Important Points
Chapter 19. Sedative-Hypnotic and Anxiolytic Drugs
Overview
Anxiety Disorders
Sleep Disorders
Sedative-Hypnotic Drugs
Summary of Important Points
Chapter 20. Antiepileptic Drugs
Overview
Treatment of Seizure Disorders
The Management of Seizure Disorders
Summary of Important Points
Chapter 21. Local and General Anesthetics
Overview
Local Anesthetics
General Anesthetics
Summary of Important Points
Chapter 22. Psychotherapeutic Drugs
Overview
Schizophrenia
Antipsychotic Drugs
Affective Disorders
Antidepressant Drugs
Mood-Stabilizing Drugs
Central Nervous System Stimulants
Summary of Important Points
Chapter 23. Opioid Analgesics and Antagonists
Overview
Pain and Analgesic Agents
Pain Pathways
Opioid Peptides and Receptors
Opioid Drugs
Specific Agents
The Treatment of Pain
Summary of Important Points
Chapter 24. Drugs for Neurodegenerative Diseases
Overview
Parkinson Disease
Alzheimer Disease
Huntington Disease
Multiple Sclerosis
Amyotrophic Lateral Sclerosis
Antispastic Agents
Summary of Important Points
Chapter 25. Drugs of Abuse
Overview
Central Nervous System Depressants
Central Nervous System Stimulants
Other Psychoactive Drugs
Prescription Drug Abuse
OTC Drugs of Abuse
Steroid Drug Abuse
Inhalant Abuse
Management of Drug Abuse
Summary of Important Points
Section V. PHARMACOLOGY OF RESPIRATORY AND OTHER SYSTEMS
Chapter 26. Autacoid Drugs That Mimic Endogenous Substances
Overview
Histamine and Related Drugs
Antihistamine Drugs
Serotonin and Related Drugs
Eicosanoids and Related Drugs
Eicosanoid Drugs
Endothelin-1 Antagonists
Summary of Important Points
Chapter 27. Pharmacological Treatment of Respiratory Disorders
Overview
Anti-Inflammatory Drugs
Bronchodilators
Monoclonal Antibodies
Management of Asthma
Antitussives
Expectorants
Management of Rhinitis
Drugs for Cystic Fibrosis
Summary of Important Points
Chapter 28. Pharmacological Treatment of Gastrointestinal Disorders
Overview
Drugs for Peptic Ulcer Disease
Treatment of Helicobacter pylori Infection
Drugs for Inflammatory Bowel Diseases
Drugs for Constipation
Antidiarrheal Agents
Drugs for Nausea and Vomiting
Summary of Important Points
Chapter 29. Drugs for Headache Disorders
Overview
Characteristics and Pathogenesis of Migraine Headaches
Drugs for Migraine Headaches
Drugs for Migraine Prevention
Drugs for Migraine Termination
Guidelines for Managing Migraine Headaches
Characteristics and Treatment of Cluster Headaches
Characteristics and Treatment of Tension Headaches
Summary of Important Points
Chapter 30. Drugs for Pain, Inflammation, and Arthritic Disorders
Overview
Rheumatoid Arthritis
Osteoarthritis
Gout
Nonsteroidal Anti-Inflammatory Drugs
Disease-Modifying Antirheumatic Drugs
Drugs for the Treatment of Gout
Summary of Important Points
Section VI. ENDOCRINE PHARMACOLOGY
Chapter 31. Hypothalamic and Pituitary Hormone Drugs
Overview
Anterior Pituitary Hormones
Posterior Pituitary Hormones
Summary of Important Points
Chapter 32. Drugs for the Treatment of Thyroid Disorders
Overview
Thyroid Disorders
Thyroid Hormone Preparations
Antithyroid Agents
Drugs for Thyroid Treatment After Nuclear Reactor Accident or Nuclear Bomb Explosion
Summary of Important Points
Chapter 33. Adrenal Steroids and Related Drugs
Overview
Synthesis and Secretion of Adrenal Steroids
Physiologic Effects of Adrenal Steroids
Corticosteroid Drugs
Adrenal Androgens
Corticosteroid Synthesis Inhibitors
Corticosteroid Receptor Antagonists
Dhea Use in Older Men
Summary of Important Points
Chapter 34. Fertility and Reproduction Drugs
Overview
Estrogens and Progestin Drugs
Contraceptives
Selective Estrogen Receptor Modulators
Antiprogestins
Aromatase Inhibitors
Androgens
Antiandrogens
Agents for Treating Dysmenorrhea and Female Sexual Dysfunction
Drug Therapy for Hirsutism and Gender Transition
Drugs Used in Obstetrics
Summary of Important Points
Chapter 35. Drugs for the Treatment of Diabetes
Overview
Diabetes
Insulin Preparations
Other Antidiabetic Agents
Dopamine Agonist
Management of Diabetes
Summary of Important Points
Chapter 36. Drugs Affecting Calcium and Bone Formation
Overview
Pharmacologic Agents
Management of Calcium and Bone Disorders
Summary of Important Points
Section VII. ANTIMICROBIAL AND CHEMOTHERAPEUTIC AGENTS
Chapter 37. Principles of Antimicrobial Chemotherapy
Overview
Classification of Antimicrobial Drugs
Antimicrobial Activity
Microbial Sensitivity and Resistance
Selection of Antimicrobial Drugs
Combination Drug Therapy
Prophylactic Therapy
Summary of Important Points
Chapter 38. Antibiotics That Inhibit Bacterial Cell Wall Synthesis
Overview
β-Lactam Antibiotics
Other Bacterial Cell Wall Synthesis Inhibitors
Summary of Important Points
Chapter 39. Antibiotics That Inhibit Bacterial Protein Synthesis
Overview
Sites of Drug Action
Drugs That Affect the 30s Ribosomal Subunit
Drugs That Affect the 50s Ribosomal Subunit
Other Protein Synthesis Inhibitors
Summary of Important Points
Chapter 40. Other Antimicrobial Agents Such as Quinolones and Antifolate Drugs
Overview
Antifolate Drugs
Fluoroquinolones
Adverse Effects and Interactions
Other Antibacterial Drugs
Summary of Important Points
Chapter 41. Antimycobacterial Drugs for Treating Tuberculosis and Other Diseases
Overview
Mycobacterial Infections
Drugs For Mycobacterial Infections
Drugs for M. Avium-intracellulare Infections
Drugs For Leprosy
Summary of Important Points
Chapter 42. Drugs for the Treatment of Fungal Infections
Overview
Clinical Uses and Mechanisms of Antifungal Drugs
Antifungal Drugs
Summary of Important Points
Chapter 43. Drugs for the Treatment of Viral Infections
Overview
Drugs for Herpesvirus Infections
Pharmacokinetics and Indications
Drugs for Human Immunodeficiency Virus Infection
Drugs for Influenza
Drugs for Hepatitis and Other Viral Infections
Drugs for Smallpox Infections
Treatment of Sars-Cov-2 Infections
Summary of Important Points
Chapter 44. Drugs for the Treatment of Parasites
Overview
Drugs for Infections Caused By Lumen- and Tissue-Dwelling Protozoa
Drugs for Infections Caused by Blood- and Tissue-Dwelling Protozoa
Drugs for Infections Caused By Helminths
Summary of Important Points
Chapter 45. Antineoplastic Agents
Overview
Principles of Cancer Therapy
Antineoplastic Drugs
Small Molecule Inhibitors
Hormonal Agents
Summary of Important Points
Chapter 46. Immunopharmacology, Biologicals, and Gene Therapy
Overview
Monoclonal Antibody Drugs
Biologicals
Gene Therapy Agents
Summary of Important Points
Answers and Explanations
Index