Bone Mineral Metabolism in Cancer

Purchase options

LIMITED OFFER

Save 50% on book bundles

Immediately download your ebook while waiting for your print delivery. No promo code is needed.

Institutional subscription on ScienceDirect

Recent Results in Cancer Research: Bone Mineral Metabolism in Cancer presents the clinical approach to bone tissue metabolism, which depends on studying the plasma state, renal handling, kinetics, and balance of calcium and inorganic phosphate. This book discusses the problems of bone mineral metabolism in patients with cancer. Organized into five chapters, this book begins with an overview of the two major phases of bone mineral, namely, amorphous calcium phosphate and crystalline bone apatite. This text then examines the plasma state and renal handling of calcium and inorganic phosphate under controlled metabolic conditions. Other chapters consider the variability of each parameter in the majority of patients without bone secondaries. This book discusses as well the normal remodeling of bone in fertile-age women. The final chapter deals with the plasma state, renal handling, and kinetics of calcium and phosphate in plasmacytoma patients. This book is a valuable resource for oncologists.

Chapter 1 General Outlines of Bone Tissue Metabolism 1. Structure and Function of Bone Cells 2. Structure and Function of Bone Matrix 2.1. Collagen 2.2. Ground Substance 3. Bone Mineral Chemistry and Structure of Bone Mineral Amorphous/Crystalline Mineral Composition Properties of Bone Mineral Mineralization of Bone Regulation of Mineralization Resorption of Bone MineralChapter 2 General Outlines of a Clinical Approach to Bone Tissue Metabolism 1. Calcium Metabolism Calcium Absorption Calcium in Body Fluids Renal Handling of Calcium Bone Calcium Accretion and Resorption Application of Tracer Kinetics to Calcium Metabolism Skeletal Hormones and Calcium Metabolism 2. Inorganic Phosphate Metabolism Phosphate in Body Fluids Renal Handling of Phosphate Application of Tracer Kinetics to Phosphate Metabolism Skeletal Hormones and Phosphate Metabolism 3. Collagen Metabolism and Urinary Hydroxyproline 4. Pyrophosphate Metabolism and Urinary PyrophosphateChapter 3 Methods of Studying Bone Mineral Metabolism 1. Plasma State and Renal Handling of Calcium and Phosphate General Design of Study Preparation and Ultrafiltration of Plasma Preparation of Urine Calculation of Diffusible Calcium and Phosphate Calculation of Renal Handling of Calcium and Phosphate 2. Kinetics of Calcium Metabolism General Design of Study Tracers Kinetic Study Preparation of Samples for Analysis and Radioactivity Determinations Preliminary Presentation of Data 3. Kinetics of Inorganic Phosphate Metabolism General Design of Study Tracer Kinetic Study Preparation of Samples for Analysis and Radioactivity Determination Preliminary Presentation of Data 4. Multicompartmental Analysis of Calcium and Phosphate Kinetics 5. Urinary Pyrophosphate 6. Other MethodsChapter 4 The Metabolism of Bone Mineral in Malignancy without Evidence of Bone Destruction 1. Metabolism of Calcium and Inorganic Phosphate 1.1. Clinical Material 1.2. Results 2. Effects of Castration on Plasma State and Renal Handling of Calcium and Inorganic Phosphate 2.1. Clinical Material 2.2. Results 3. Discussion 3.1. Plasma State of Calcium and Inorganic Phosphate 3.2. Renal Handling of Calcium and Inorganic Phosphate 3.3. Effects of Castration on Bone Mineral Metabolism 3.4. Calcium Kinetics 3.5. Phosphate KineticsChapter 5 The Metabolism of Bone Mineral in Malignancy with Bone Lesions 1. Patients with Plasmacytoma 1.1. Clinical Material 1.2. Results 2. Patients with Cancer of the Breast 2.1. Clinical Material 2.2. Results 3. Discussion 3.1. Patients with Plasmacytoma 3.2. Patients with Cancer of the BreastGeneral SummaryAppendix An Analytical Solution of the Parallel Three-Compartment Open System Model Notations AnalysisReferencesSubject Index