Bone Mineral Metabolism in Cancer

Bone Mineral Metabolism in Cancer

Recent Results in Cancer Research

1st Edition - January 1, 1970

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  • Author: Janusz Szymendera
  • eBook ISBN: 9781483193052

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Description

Recent Results in Cancer Research: Bone Mineral Metabolism in Cancer presents the clinical approach to bone tissue metabolism, which depends on studying the plasma state, renal handling, kinetics, and balance of calcium and inorganic phosphate. This book discusses the problems of bone mineral metabolism in patients with cancer. Organized into five chapters, this book begins with an overview of the two major phases of bone mineral, namely, amorphous calcium phosphate and crystalline bone apatite. This text then examines the plasma state and renal handling of calcium and inorganic phosphate under controlled metabolic conditions. Other chapters consider the variability of each parameter in the majority of patients without bone secondaries. This book discusses as well the normal remodeling of bone in fertile-age women. The final chapter deals with the plasma state, renal handling, and kinetics of calcium and phosphate in plasmacytoma patients. This book is a valuable resource for oncologists.

Table of Contents


  • Chapter 1 General Outlines of Bone Tissue Metabolism

    1. Structure and Function of Bone Cells

    2. Structure and Function of Bone Matrix

    2.1. Collagen

    2.2. Ground Substance

    3. Bone Mineral

    Chemistry and Structure of Bone Mineral

    Amorphous/Crystalline Mineral Composition

    Properties of Bone Mineral

    Mineralization of Bone

    Regulation of Mineralization

    Resorption of Bone Mineral

    Chapter 2 General Outlines of a Clinical Approach to Bone Tissue Metabolism

    1. Calcium Metabolism

    Calcium Absorption

    Calcium in Body Fluids

    Renal Handling of Calcium

    Bone Calcium Accretion and Resorption

    Application of Tracer Kinetics to Calcium Metabolism

    Skeletal Hormones and Calcium Metabolism

    2. Inorganic Phosphate Metabolism

    Phosphate in Body Fluids

    Renal Handling of Phosphate

    Application of Tracer Kinetics to Phosphate Metabolism

    Skeletal Hormones and Phosphate Metabolism

    3. Collagen Metabolism and Urinary Hydroxyproline

    4. Pyrophosphate Metabolism and Urinary Pyrophosphate

    Chapter 3 Methods of Studying Bone Mineral Metabolism

    1. Plasma State and Renal Handling of Calcium and Phosphate

    General Design of Study

    Preparation and Ultrafiltration of Plasma

    Preparation of Urine

    Calculation of Diffusible Calcium and Phosphate

    Calculation of Renal Handling of Calcium and Phosphate

    2. Kinetics of Calcium Metabolism

    General Design of Study

    Tracers

    Kinetic Study

    Preparation of Samples for Analysis and Radioactivity Determinations

    Preliminary Presentation of Data

    3. Kinetics of Inorganic Phosphate Metabolism

    General Design of Study

    Tracer

    Kinetic Study

    Preparation of Samples for Analysis and Radioactivity Determination

    Preliminary Presentation of Data

    4. Multicompartmental Analysis of Calcium and Phosphate Kinetics

    5. Urinary Pyrophosphate

    6. Other Methods

    Chapter 4 The Metabolism of Bone Mineral in Malignancy without Evidence of Bone Destruction

    1. Metabolism of Calcium and Inorganic Phosphate

    1.1. Clinical Material

    1.2. Results

    2. Effects of Castration on Plasma State and Renal Handling of Calcium and Inorganic Phosphate

    2.1. Clinical Material

    2.2. Results

    3. Discussion

    3.1. Plasma State of Calcium and Inorganic Phosphate

    3.2. Renal Handling of Calcium and Inorganic Phosphate

    3.3. Effects of Castration on Bone Mineral Metabolism

    3.4. Calcium Kinetics

    3.5. Phosphate Kinetics

    Chapter 5 The Metabolism of Bone Mineral in Malignancy with Bone Lesions

    1. Patients with Plasmacytoma

    1.1. Clinical Material

    1.2. Results

    2. Patients with Cancer of the Breast

    2.1. Clinical Material

    2.2. Results

    3. Discussion

    3.1. Patients with Plasmacytoma

    3.2. Patients with Cancer of the Breast

    General Summary

    Appendix An Analytical Solution of the Parallel Three-Compartment Open System Model

    Notations

    Analysis

    References

    Subject Index


Product details

  • No. of pages: 118
  • Language: English
  • Copyright: © Butterworth-Heinemann 1970
  • Published: January 1, 1970
  • Imprint: Butterworth-Heinemann
  • eBook ISBN: 9781483193052

About the Author

Janusz Szymendera

About the Editors

V. G. Allfrey

M. Allgöwer

K. H. Bauer

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