Regulatory Perspectives on Clinical Trials for Oxygen Therapeutics in Trauma and Transfusion Practice
Clinical Physiology: Oxygen Transport and the Transfusion Trigger
The Role of Oxygen and Hemoglobin Diffusion in Oxygen Transport by Cell-Free Hemoglobins
Oxygen Transport Properties of Hemoglobin- Based Oxygen Carriers: Studies Using Artificial Capillaries and Mathematical Stimulation
Mechanisms of O2 Transport in the Microcirculation: Effects of Cell-Free O2 Carriers
Shear Stress, Mechanotransduction and the Flow Properties of Blood
Local Regulation of Blood Flow
Clinical Indications for Blood Substitutes and Optimal Properties
Hemoglobin-Based Oxygen Carriers as Resuscitative Solutions for Trauma and Combat Casualty Care
Clinical Trials in Cardiac Surgery
Potential for Blood Substitutes in Tissue Ischemia
TOXICITY AND SIDE EFFECTS
Redox and Radical Reactions of Hemoglobin Solutions: Toxicities and Protective Strategies
Pro-oxidant Activity of Hemoglobin and Endothelial Cytotoxicity
Hemoglobin and Neurotoxicity
The Role of Inflammation in the Toxicity of Hemoglobin-based Oxygen Carriers
Hemoglobin-Induced Myocardial Lesions
PERFLUOROCARBON-BASED OXYGEN CARRIERS
Fluorocarbon Emulsions As In Vivo Oxygen Delivery Systems: Background And Chemistry
Fluosol: The First Commercial Injectable Perfluorocarbon Oxygen Carrier
- No. of pages:
- © 2005
5th October 2005
- eBook ISBN:
- Print ISBN:
Professor Winslow received his M.D. degree and postgraduate training in internal medicine and hematology at the Johns Hopkins University and Hospital. He studied hemoglobin biochemistry at the Massachusetts Institute of Technology and Molecular Biology at the National Institutes of Health. His research, for more than 30 years, has been aimed at the intersection of the synthesis, structure and function of hemoglobin, in such areas as sickle cell anemia, high altitude physiology and hemoglobin-based oxygen carriers. Professor Winslow previously headed the Blood Research Division at the Letterman Army Institute of Research, responsible for the US Army's blood substitute program. Between 1991 and 1998, he was a Professor of Medicine, leading a blood substitute program at the University of California at San Diego (UCSD), supported by the National Institutes of Health. Professor Winslow has also served as a consultant to many private companies and has been an advisor for, among others, the Federal Aviation Administration (FAA), Food and Drug Administration (FDA), the Institute of Medicine of the National Academy of Science, the Pan American Health Organization, the National Institutes of Health, the Department of Defense and a number of foreign governments. He has written more than 200 scientific articles on clinical, physiological and biochemical aspects of hemoglobin and oxygen transport.
Affiliations and Expertise
University of California, Department of Medicine and Veterans Affairs Medical Center, San Diego, U.S.A.
"Robert Winslow's new book Blood Substitutes, is useful in many ways. It brings together well-written summaries of the work of many of the most important investigators of the last 2 decades in the broad group of interrelated fields. Moreover, it also has some excellent chapters of scientific and medical background that provide context for the work. It also gives a historical snapshot of the thinking and attitudes of workers in the field. As an introduction to the field, this book is outstanding."
- John R. Hess MD, MPH, FACPa, University of Maryland Medical Center for TRANSFUSION MEDICINE REVIEWS (2006)
"There aren't too many all in one books on this subject, let alone one written this clearly, concisely, and with perspective. If you are interested in this field, get this book."
- Doody's 3 Star Review by Valerie L. Ng, PhD, MD, Alameda County Medical Center/Highland Hospital (2006)
"This is a serious, comprehensive, authoritative and highly readable textbook on a most relevant and challenging topic – the search for blood substitutes. ...The Editor and publishers have clearly given considerable thought to the readability as well as the academic rigour of the 46 chapters and 548 pages. In this reviewer’s opinion, they have been most successful. The font and the page layouts are easy on the eye, the illustrations of good quality, and the references for each chapter are comprehensive and up to date. The potential readership for this book will undoubtedly be broadly based. This is a
quality text book, and, although it is always difficult to define quality, we do recognise it when we come across it."
- Professor Ken Taylor, British Heart Foundation Professor of Cardiac Surgery, University of London
and Director of Cardiac Services, Hammersmith Hospital, London, UK