Recent research into the anatomy and pathophysiology of the blood-brain and blood-spinal cord barriers suggests that a breakdown in these barriers can result in several diseases affecting the central nervous system (CNS). This book presents new findings in the area of blood-brain barrier research that suggest barriers play important roles in health and disease conditions. It also discusses the development of new drugs that can modulate the barrier function in the CNS and may provide new approaches to treating neurological diseases such as Alzheimer's disease and other motor neuron diseases, as well as spinal cord trauma.

Key Features

Key Features * Presents the recent progress made in the research on the blood-brain and spinal cord barrier * Contains numerous illustrations of light and electron micrographs * Includes Foreword written by two eminent researchers in the field, Milton Brightman and Jorge Cervos-Navarro


Researchers in neuroscience, drug discovery and development, and neuropathology.

Table of Contents

Section I. Basic Aspects: Structure and Functions of Cerebrovascular Barriers Section II. Technical & Functional Aspects: Cerebrovascular Barriers In Vitro Section III. Physiological Aspects: Transport Mechanisms Across Cerebrovascular Barriers Section IV. Pharmacological Aspects: Neurochemical Mediators of the Cerebrovascular Barriers Section V. Neuropsychological Aspects: Cerebrovascular Barriers in Stressful Situations Section VI. Neurological Aspects: Alterations of Cerebrovascular Barriers in Disease Conditions Section VII. Clinical Aspects: Cerebrovascular Barriers in Clinical Conditions Future Perspectives


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© 2003
Academic Press
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"'Blood-Spinal Cord and Brain Barriers in Health and Disease' is a contemporary and very informative volume that should be a ready source of reference for all researchers and clinicians concerned with the CNS in health and disease." --Cerebrospinal Fluid Research (June 2005)