Biopharmaceutical Processing: Development, Design, and Implementation of Manufacturing Processes covers bioprocessing from cell line development to bulk drug substances. The methods and strategies described are essential learning for every scientist, engineer or manager in the biopharmaceutical and vaccines industry.
The integrity of the bioprocess ultimately determines the quality of the product in the biotherapeutics arena, and this book covers every stage including all technologies related to downstream purification and upstream processing fields. Economic considerations are included throughout, with recommendations for lowering costs and improving efficiencies. Designed for quick reference and easy accessibility of facts, calculations and guidelines, this book is an essential tool for industrial scientists and managers in the biopharmaceutical industry.
- Offers a comprehensive, go-to reference for daily work decisions
- Covers both upstream and downstream processes
- Includes case studies that emphasize financial outcomes
- Presents summaries, decision grids, graphs and overviews for quick reference
Chemical/biochemical/bioprocess engineers, process chemists, analytical chemists, molecular biologists, microbiologists, biochemists/ biotechnologists, virologists, graduate-level students in these disciplines
1. Overview of Biotherapeutics and Vaccine Industry
2. Industrial Process Design Concepts
3. Single-Use Concepts in Manufacturing
4. Equipment and Automation
5. Facility Design
6. Process Development Routines
7. Production Sources and their Selection
8. Upstream Processing
9. Downstream Processing 1: Recovery Process
10. Downstream Processing 2: Purification Process
11. Downstream Related Methods
13. Regulatory Aspects
14. Manufacturing Operations
- No. of pages:
- © Elsevier 2018
- 15th December 2017
- Hardcover ISBN:
Dr. Jagschies is a 30-plus year employee at GE Healthcare Life Sciences and a globally recognized expert in bioprocessing. He has published numerous papers and two books on the development, manufacturing and economics of biotherapeutics, and in 2012 he received the BioProcess International award “Thought Leader of the Decade”.
Strategic Customer Relations Leader, GE Healthcare, Freiburg im Breisgau, Germany
Dr. Lindskog has degrees in chemical engineering and bioprocess technology. She has been working across the biopharmaceutical process, with a focus on innovation in upstream technology.
Associate Director Marketing, Lonza Pharma & Biotech, Basel, Switzerland
Dr. Lacki’s educational background is in process and chemical engineering, and he is heavily involved in R&D projects related to chromatography media development, process development and validation, and facility design.
VP Technology Development, Avitide, USA
In December 2002, Mr. Galliher became Founder, President and CEO of Xcellerex, an advanced technology contract biomanufacturing and disposable manufacturing systems company. In December 2004, Mr. Galliher transitioned to Founder and Chief Technology Officer of Xcellerex, Inc. As Principal Investigator, Mr. Galliher has led Xcellerex’s $19 M US Gov’t DoD contract for the “Accelerated Manufacture of Pharmaceuticals Program” (AMP), awarded in 2007 and continued through completion of Phase 2 Live Fire Test in 2009. Mr. Galliher is co- inventor on numerous patents in the field of biomanufacturing. In 2012 he received the BioProcess International Award as “Thought Leader of the Decade” in the Upstream Processing category. He currently holds the role of Chief Technology Officer at GE Healthcare for the Upstream Bioprocessing business.
Chief Technology Officer, GE Healthcare for the Upstream Bioprocessing Business