Biomechanics of the Female Reproductive System: Breast and Pelvic Organs

From Model to Patient

1st Edition - April 21, 2023
Editors: Mathias Brieu, Michel Cosson, Poul Nielsen
Language: English
Hardback ISBN:
9 7 8 - 0 - 3 2 3 - 9 0 3 1 9 - 6
eBook ISBN:
9 7 8 - 0 - 1 2 - 8 2 3 6 7 6 - 5

Biomechanics of the Female Reproductive System: Breast and Pelvic Organs: From Models to Patients synthesizes complementary advances in women’s reproductive biomechanics, medical i… Read more

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Biomechanics of the Female Reproductive System: Breast and Pelvic Organs: From Models to Patients synthesizes complementary advances in women’s reproductive biomechanics, medical imaging analysis, patient-specific characterization, and computational finite element models. The book discusses the biomechanical aspects related to the breast and female pelvic floor system at each step of development. The table of contents also covers certain events and diseases, including cancers, delivery, aging, breast, hysterectomy or prolapse surgery. It presents the main biomechanical experimental results obtained and models developed this last decade to highlight the importance of accounting for patient-specific history and aging characteristics to consider damage growth effect and impact.

As part of Elsevier’s Biomechanics of Living Organs series, this book provides an opportunity for students, researchers, clinicians and engineers to study the main topics related to the biomechanics of the women’s reproductive system in a single book written by a global base of experts.

Cover image
Title page
Table of Contents
Copyright
Contributors
Editor's biography of 2022
Foreword
Preface
Note of the series editors
Part 1: Backgrounds: anatomy, physiology, and physio-pathology
Chapter 1: Pelvic floor functional anatomy
Abstract
1.1. Overview
1.2. Levator ani
1.3. Connective tissue supports of the pelvic organs
References
Chapter 2: Epidemiology & pathophysiology of pelvic organ prolapse & urinary incontinence in women
Abstract
2.1. Epidemiology of pelvic organ prolapse
2.2. Pathophysiology of pelvic organ prolapse
2.3. Epidemiology of urinary incontinence
2.4. Pathophysiology of urinary incontinence
References
Chapter 3: Current surgical treatments for women's genital prolapse
Abstract
3.1. Introduction
3.2. Signs and symptoms of genital prolapse
3.3. Surgical indications and alternative treatments
3.4. Surgical techniques
3.5. Surgical strategies
3.6. Mechanical consequences of the different management options
Chapter 4: Physiology and physiopathology of pregnancy and delivery
Abstract
4.1. Introduction
4.2. Changes in biomechanical intrinsic characteristics during pregnancy
4.3. Pathophysiological process
4.4. Association with the mode of delivery and the risk of perineal trauma at childbirth
4.5. Biomechanics of spontaneous normal delivery
4.6. Peripartum biomechanical considerations
4.7. Model development, testing, and validation
4.8. Conclusion
4.9. List of Abreviations
References
Part 2: Mechanical properties – constitutive laws – experimental characterizations
Chapter 5: Inverse problems in the characterization of soft connective tissue: perspective for reproduction system
Abstract
5.1. Introduction
5.2. Common sources of inverse problem in soft tissue biomechanics
5.3. The finite element model updating method
5.4. Sequential methods
5.5. The virtual fields method
5.6. Conclusions and future directions emerging field of pelvic biomechanics
References
Chapter 6: Mechanical properties of women pelvic soft tissues
Abstract
6.1. Introduction
6.2. Vagina
6.3. Uterus
6.4. Uterosacral ligaments
6.5. Levator ani
References
Chapter 7: Mechanical properties of breast tissue
Abstract
7.1. Introduction
7.2. Mechanics of breast tissue
7.3. A community's use of mechanics
7.4. Final remarks and future directions
References
Chapter 8: Evolution of mechanical properties with pathology & aging: application to pelvic tissues?
Abstract
8.1. Introduction
8.2. Mechanical properties of tissues
8.3. The mechanical importance of tissue composition and microstructure
8.4. Conclusion
References
Chapter 9: Mechanical properties of pelvic implants: interaction between implants and tissue
Abstract
9.1. Motivation
9.2. Mechanical and physical properties of prosthetic meshes
9.3. Experimental mechanical characterization of prosthetic meshes
9.4. Numerical modeling of pelvic implants
9.5. Alternative materials: electrospun networks
9.6. What are the needs?
References
Chapter 10: Constitutive models of soft connective tissues under large strain: application to pelvic tissue?
Abstract
10.1. Introduction
10.2. Mechanical formulation
10.3. Isotropic modeling
10.4. Anisotropic modeling
10.5. Conclusion
References
Part 3: Clinical imaging, investigations tools, and characterization
Chapter 11: Medical imaging and patient-specific modeling of women pelvic system: application to magnetic resonance images
Abstract
Acknowledgements
11.1. Introduction
11.2. Materials and methods
11.3. Applications and discussion
11.4. Conclusions
References
Chapter 12: Quantitative assessment of pelvic mobility in women using MRI image analysis
Abstract
12.1. Introduction
12.2. Method for quantifying pelvic mobility
12.3. Method for quantifying pelvic mobility
12.4. Inter-organs displacements
12.5. Discussion
12.6. Conclusion
References
Chapter 13: Patient-specific biomechanical modeling for applications in breast cancer diagnosis and treatment
Abstract
Acknowledgements
13.1. Introduction
13.2. Anatomical modeling
13.3. Applications
13.4. Challenges and opportunities
References
Chapter 14: Ultrasound elastography: in vivo assessment of tissue stiffness
Abstract
14.1. Introduction
14.2. Principles of elastography
14.3. Clinical applications for breast and cervix
14.4. Conclusion
References
Part 4: From biomechanical models to medical devices, and patients treatments
Chapter 15: Numerical simulation of vaginal delivery
Abstract
Acknowledgements
15.1. Introduction
15.2. The three phases of a vaginal birth
15.3. Interest to perform a childbirth training simulator
15.4. A real-time childbirth simulation
15.5. Accurate childbirth simulations
15.6. Conclusion & perspective
References
Chapter 16: Numerical models for breast surgery and reconstruction
Abstract
Acknowledgements
16.1. Introduction
16.2. Previous work on breast biomechanical modeling to aid registration and surgical planning
16.3. Towards surgical guidance
16.4. Symmetric biomechanically guided prone-to-supine breast image registration for surgical and radiotherapy planning
16.5. Multiscale mechano-biological finite element modeling of oncoplastic breast surgery: numerical study towards surgical planning and cosmetic outcome prediction
16.6. Conclusion
Dedication
References
Chapter 17: A numerical model for prolapse surgery
Abstract
Abbreviations
17.1. Introduction
17.2. Material and methods
17.3. Results
17.4. Discussion
17.5. Conclusion
References
Chapter 18: Augmented reality biomechanical simulations for pelvic conditions diagnoses
Abstract
18.1. Introduction
18.2. Simulation of deformable structures
18.3. Registration of biomechanical models
18.4. Applications
18.5. Conclusion
References
Chapter 19: Towards patient-specific treatment in gynecologic surgery: recent development and perspectives
Abstract
19.1. Introduction
19.2. Research investigation needs
19.3. Perspectives: Use of numerical simulation for treatment improvement in gynecology
References
Index

Mathias Brieu

He is a Professor of Mechanical Engineering with a specialty in mechanics of materials and computational mechanics. Prior to joining Cal State LA, he was a Professor in a higher education school of engineering: Centrale Lille. He still interacts with his former institution and his research is developed in a synergy between France and the USA; his specialty now is Biomedical Engineering. His research activities are based on the triptych of mechanics of materials: experimental characterization constitutive modelling, and numerical and computational methods. He is focused on soft polymers and bio-polymers. His activities can be summarized in 3 fields: •Behavior, and damage of synthetic polymers •Behavior of human soft tissue and medical implants, •Development and design of Medical Devices for patient-specific surgery.

Affiliations and expertise

PhD, Professor of mechanical engineering at California State University in Los Angeles, United States; Professor of mechanics at Centrale Lille, France.

Michel Cosson

Pr. Michel Cosson is the Medical director of the UNF3S French numerical university. He is involved in 3D anatomy and pedagogical research. He is also the Head of the Gynecological unit of the University Hospital in Lille, France and Professor of Gynecology Obstetrics at the Medical University. He is the author and co-author of several publications. Pr. Cosson’s areas of interest include biomechanical properties of pelvic tissues & 3D biomechanical simulation of the female pelvic cavity.

Affiliations and expertise

Professor of Gynecology and Obstetrics, Lille University, France; President, Group for Pelviperineology of the French Medical Society of Gynecology and Obstetrics

Poul Nielsen

Poul's research focuses on using novel instrumentation, detailed computational models, and quantitative descriptions of physical processes to gain a better understanding of human physiology. Many of his projects couple mathematical modelling with innovative instrumentation to improve our ability to understand and interpret measurements of complex biological systems, subject to the constraints of well-understood physical conservation and balance laws.

Affiliations and expertise

Professor of Biomechanics and Computational Mechanics, Chair of the Physiome Incorporated Executive Committee and Member, VPH Institute Board of Directors, Auckland Bioengineering Institute, University of Auckland, New Zealand