Biomaterials Science - 1st Edition - ISBN: 9780080500140

Biomaterials Science

1st Edition

An Introduction to Materials in Medicine

Editors: Buddy Ratner Allan Hoffman Frederick Schoen Jack Lemons
eBook ISBN: 9780080500140
Imprint: Academic Press
Published Date: 20th May 1997
Page Count: 484
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This book introduces a subject that has profound impact on human health and considerable economic importance. The issues addressed include the biology, medical applications, markets, regulation, and ethical issues involved in biomaterials science. This spectrum of issues reflects the interdisciplinary nature of the field.

Key Features

  • Provides a strong, cohesive compilation unlike any other currently on the market
  • Covers the entire spectrum of biomaterials and their use in medicine
  • Contributions of leaders in the biomaterials field


Researchers, scientists, and students in the fields of biomaterials, chemistry, physics, engineering, biology, medicine, veterinary medicine, orthopedics, dentistry, including scientists in biotechnology and industry. In addition, attorneys involved in biomaterials litigation, materials scientists, and medical personnel will find much of interest in this book. This area is well-funded by NIH.

Table of Contents

B.D. Ratner, Biomaterials Science: An Interdisciplinary Endeavor.

Materials Science and Engineering--Properties of Materials:

J.E. Lemons, Introduction.

F.W. Cooke, Bulk Properties of Materials.

B.D. Ratner, Surface Properties of Materials.

Classes of Materials Used in Medicine:

A.S. Hoffman, Introduction.

J.B. Brunski, Metals.

S.A. Visser, R.W. Hergenrother, and S.L. Cooper, Polymers.

N.A. Peppas, Hydrogels.

J. Kohnand R. Langer, Bioresorbable and Bioerodible Materials.

L.L. Hench, Ceramics, Glasses, and Glass Ceramics.

I.V. Yannas, Natural Materials.

H. Alexander, Composites.

B.D. Ratner and A.S. Hoffman, Thin Films, Grafts, and Coatings.

S.W. Shalaby, Fabrics.

A.S. Hoffman, Biologically Functional Materials.

Biology, Biochemistry, and Medicine--Some Background Concepts:

B.D. Ratner, Introduction.

T.A. Horbett, Proteins: Structure, Properties, and Adsorption to Surfaces.

J.M. Schakenraad, Cells: Their Surfaces and Interactions with Materials.

F.J. Schoen, Tissues.

Host Reactions to Biomaterials and Their Evaluations:

F.J. Schoen, Introduction.

J.M. Anderson, Inflammation, Wound Healing, and the Foreign Body Response.

R.J. Johnson, Immunology and the Complement System.

K. Merritt, Systemic Toxicity and Hypersensitivity.

S.R. Hanson and L.A. Harker, Blood Coagulation and Blood-Materials Interaction.

F.J.Schoen, Tumorigenesis and Biomaterials.

A.G. Gristina and P.T. Naylor, Implant-Associated Infection.

Testing Biomaterials:

B.D. Ratner, Introduction.

S.J. Northup, In Vitro Assessment of Tissue Compatibility.

M. Spector and P.A. Lalor, In Vivo Assessment of Tissue Compatibility. S. Hanson and B.D. Ratner, Testing of Blood-Material Interactions.

B.H. Vale, J.E. Willson, and S.M. Niemi, Animal Models.

Degradation of Materials in the Biological Environment:

B.D. Ratner, Introduction.

A.J. Coury, Chemical and Biochemical Degradation of Polymers.

D.F. Williams and R.L. Williams, Degradative Effects of the Biological Environment on Metals and Ceramics.

C.R. McMillin, Mechanical Breakdown in the Biological Environment.

Y. Pathak, F.J. Schoen, and R.J. Levy, Pathologic Calcification of Biomaterials.

Application of Materials in Medicine and Dentistry:

J.E. Lemons, Introduction.

D. Didisheim and J.T. Watson, Cardiovascular Applications.

S.W. Kim, Nonthrombogenic Treatments and Strategies.

J.E. Lemons, Dental Implants.

D.C. Smith, Adhesives and Sealants.

M.F. Refojo, Ophthalmologic Applications.

J.L. Katz, Orthopedic Applications.

J. Heller, Drug Delivery Systems.

D. Goupil, Sutures.

J.B. Kane, R.G. Tompkins, M.L. Yarmush, and J.F. Burke, Burn Dressings.

L.S. Robblee and J.D. Sweeney, Bioelectrodes.

P. Yager, Biomedical Sensors and Biosensors.

Artificial Organs:

F.J. Schoen, Introduction.

K.D. Murray and D.B. Olsen, Implantable Pneumatic Artificial Hearts.

P. Malchesky, Extracorporeal Artificial Organs.

Practical Aspects of Biomaterials--Implants and Devices:

F.J. Schoen, Introduction.

J.B. Kowalski and R.F. Morrissey, Sterilization of Implants.

L.M. Graham, D. Whittlesey, and B. Bevacqua, Cardiovascular Implantation.

A.N. Cranin, M. Klein, and A. Sirakian, Dental Implantation.

S.A. Obstbaum, Ophthalmic Implantation.

A.E. Hoffman, Implant and Device Failure.

B.D. Ratner, Correlations of Material Surface Properties with Biological Responses.

J.M. Anderson, Implant Retrieval and Evaluation.

New Products and Standards:

J.E. Lemons, Introduction.

S.A. Brown, Voluntary Consensus Standards.

N.B. Mateo, Product Development and Regulation.

B. Ratner, Perspectives and Possibilities in Biomaterials Science.


S. Slack, Properties of Biological Fluids. Subject Index.


No. of pages:
© Academic Press 1996
Academic Press
eBook ISBN:

About the Editor

Buddy Ratner

Buddy D. Ratner, Michael L. and Myrna Darland Endowed Chair in Bioengineering and Professor of Chemical Engineering at the University of Washington, received his Ph.D. (1972) in polymer chemistry from the Polytechnic Institute of Brooklyn. From 1985-1996 he directed the NIH-funded National ESCA and Surface Analysis Center for Biomedical Problems (NESAC/BIO), and in 1996 he assumed the directorship of University of Washington Engineered Biomaterials (UWEB), an NSF Engineering Research Center. He is the editor of the Journal of Undergraduate Research in Bioengineering, a past president of the Society for Biomaterials and author of 400 scholarly works. Ratner is a fellow of the American Institute of Medical and Biological Engineering (AIMBE), the American Vacuum Society and a Fellow, Biomaterials Science and Engineering (FBSE). He served as president of AIMBE, 2002-2003. He is vice president of the Tissue Engineering Society International (TESI) 2003-2005. In 2002 Ratner was elected a member of the National Academy of Engineering, USA, and in 2004 he won the Founder’s Award for the Society For Biomaterials. His research interests include biomaterials, tissue engineering, polymers, biocompatibility, surface analysis of organic materials, self-assembly, nanobiotechnology and RF-plasma thin film deposition. Summary of Buddy Ratner’s awards and honors: 1989 Clemson Award for Contributions to the Biomaterials Literature 1990 Burlington Resources Foundation Faculty Achievement Award for Outstanding Research 1991 Perkin-Elmer Physical Electronics Award for Excellence in Surface Science 1991–1992 President, Society For Biomaterials 1993 Founding Fellow, American Institute of Medical and Biological Engineering (AIMBE) 1993 Fellow, American Vacuum Society; Vice President, AIMBE 1993 Fellow, Society For Biomaterials; Van Ness Lecturer, Rensselaer Polytechnic Institute 1998 C.M.A. Stine Award in Materials Science (AIChE); American Vacuu

Affiliations and Expertise

Professor of Chemical Engineering and Bioengineering, University of Washington

Allan Hoffman

Allan Hoffman

Professor Hoffman studied at M.I.T., where he received B.S., M.S., and Sc.D. degrees in Chemical Engineering between 1953 and 1957. He taught on the faculty of M.I.T. Chemical Engineering Department for a total of ten years. He also spent four years in industry. Since 1970 he has been Professor of Bioengineering at the University of Washington in Seattle, Washington. Professor Hoffman has over 330 publications, several books and chapters, 21 patents and several other patents pending. He is on the Editorial Boards of seven scientific journals. Summary of professional activities and awards include: •President, Society for Biomaterials, 1983-1984 •Clemson Award in Biomaterials, 1984 •Board of Governors, Controlled Release Society, 1991-1994 •Biomaterials Science Prize, Japanese Biomaterials Society, 1990 •Founders’ Award of the Society for Biomaterials, 2000 •Election to the National Academy of Engineering, 2005 In December, 1992, Hoffman's colleagues organized a symposium in Maui, Hawaii in honor of his 60th birthday. In December, 2002 his 70th birthday was celebrated at another special symposium, once again in Maui, Hawaii. Papers from the first symposium were published in the Journal of Biomaterials Science (Polymer Edition), along with a Festschrift book, and similar publications are in press at this time from the second symposium.

Affiliations and Expertise

Professor of Bioengineering University of Washington

Frederick Schoen

Frederick J. Schoen is Professor of Pathology and Health Sciences and Technology, Harvard Medical School; Director of Cardiac Pathology and Executive Vice-Chairman in the Department of Pathology at the Brigham and Women's Hospital (BWH) in Boston. Schoen received a B.S.E. (Materials and Metallurgical Engineering) from the University of Michigan (1966), a Ph.D. in Materials Science from Cornell University (1970) and an M.D. from the University of Miami School of Medicine (1974). Following a Surgery internship followed by residency in Anatomic Pathology and fellowship in Thoracic and Cardiovascular Pathology at the University of Florida, he joined BWH in 1980. Schoen has focused his research career on tissue-biomaterial interactions, structure-function-pathology correlations in the native heart valves, heart valve substitutes and other cardiovascular prostheses, calcification of bioprosthetic tissues, heart transplantation, and cardiovascular applications of tissue engineering. Schoen has leadership responsibilities in academic programs in the Department of Pathology, Harvard Medical School and the Harvard-MIT Division of Health Sciences and Technology (HST); he currently chairs the HST Faculty Appointments Committee and the Graduate (Curriculum) Committee, and is an active teacher of courses in pathology, cardiovascular pathology, and biomaterials and tissue engineering. He chairs the BWH Education Committee. Schoen is author or co-author of approximately 375 manuscripts in journals and books. He authored Interventional and Surgical Cardiovascular Pathology: Clinical Correlations and Basic Principles (1989); and was Co-Editor of Biomaterials Science: An Introduction to Materials in Medicine (1st Edition 1996, 2nd Edition 2004), and Silver’s Cardiovascular Pathology, 3rd Edition (2001). He is Past-President of the Society For Biomaterials (SFB) and the Society for Cardiovascular Pathology, and was Founding Fellow of the American In

Affiliations and Expertise

Professor of Pathology and Health Sciences and Technology Harvard Medical School

Jack Lemons

Affiliations and Expertise

Professor and Director of Biomaterials Laboratory Surgical Research University of Alabama


"...this outstanding text deserves nothing but praise...The editors have brought together 57 authors, all of whom are at the very least extremely knowledgeable in their field, and, at best, are the unquestioned leaders... There is no topic related to biomaterials that is not covered somewhere in this book... The quality of the writing, the arrangement of information and the figures are all outstanding." --POLYMER NEWS

Ratings and Reviews