Biomaterials for Neural Tissue Engineering

1st Edition - April 18, 2023
Editors: Oguzhan Gunduz, Cem Bulent Ustundag, Mustafa Sengor
Language: English
Paperback ISBN:
9 7 8 - 0 - 3 2 3 - 9 0 5 5 4 - 1
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 9 0 6 7 4 - 6

Biomaterials for Neural Tissue Engineering covers a range of materials and technologies used for regenerating or repairing neural tissue. With a strong focus on biomateri… Read more

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Biomaterials for Neural Tissue Engineering covers a range of materials and technologies used for regenerating or repairing neural tissue. With a strong focus on biomaterials and scaffolds, the book examines the testing and evaluation pathway for in-vitro and in-vivo testing trials. This book introduces the reader to the fundamentals of the nervous system from a tissue engineering perspective and goes on to describe contemporary technologies used in the development of neural repair materials, as well as currently available biomaterials suitable for neural tissue repair and regeneration.

This detailed reference is ideal for those who are new to using biomaterials in tissue engineering, particularly those interested in the nervous system, including academics and early career researchers in the fields of materials science, regenerative medicine, biomedical engineering and clinical sciences.

Cover image
Title page
Table of Contents
Copyright
Contributors
Biographies
Chapter 1. The need for biomaterials in neural tissue engineering
Chapter 2. Introduction to the nervous system from tissue engineering perspective
2.1. Introduction
2.2. Nervous system structure, neurons, neuroglial structure
2.3. Nerve injury and natural regeneration
2.4. Brain diseases and injury rehabilitation
2.5. Spinal cord injuries and central nervous system regeneration
2.6. Neural tissue engineering
2.7. Neural tissue scaffolding
Chapter 3. Natural, synthetic, and hybrid and composite biomaterials for neural tissue engineering
3.1. Introduction
3.2. Material requirements
3.3. Natural materials
3.4. Synthetic materials
3.5. Hybrid materials
3.6. Conclusion
Chapter 4. Carbon-based nanomaterials for nervous tissue engineering
4.1. Introduction
4.2. Overview of carbon-based materials (CBMs) for nervous tissue engineering
4.3. 1D carbon allotropes applied to nerve tissue engineering
4.4. 0D carbon allotropes applied to nerve tissue engineering
4.5. Final remarks
Chapter 5. Microfluidic systems for neural tissue engineering
5.1. Introduction
5.2. Neural tissue engineering
5.3. Polymers used for neural tissue engineering
5.4. Methods used in neural tissue engineering
5.5. Overview of studies on neural tissue engineering using microfluidic system
5.6. Concluding remarks and future directions
Chapter 6. Therapeutic polymer gel system in neural tissue engineering
6.1. Introduction
6.2. Neural tissue engineering
6.3. Natural polymer hydrogel for neural tissue engineering
6.4. Synthetic polymer hydrogel for neural tissue engineering
6.5. Conclusions
Chapter 7. Growth factor delivery for neural tissue engineering
7.1. Introduction
7.2. Biological considerations
7.3. Material selection
7.4. Delivery strategies for growth factor
7.5. Conclusion
Chapter 8. Computational methods in modeling of scaffolds for neural tissue engineering
8.1. Computer-Aided Tissue Engineering (CATE)
8.2. Finite element method—indispensable tool for TE scaffold design
8.3. TE scaffold optimization methods
8.4. Use of artificial intelligence methods in TE scaffold design
8.5. Numerical models of TE scaffold degradation
8.6. Computational models of tissue regeneration
Chapter 9. Drug delivery systems for neural tissue engineering
9.1. Polymeric nanoparticles (PNPs)
9.2. Silica nanoparticles
9.3. Magnetic nanoparticles
9.4. Metallic nanoparticles
9.5. Liposomes
9.6. Lipoplex and polyplex nanoparticles
9.7. Lipid nanoparticles
9.8. Quantum dots (QD)
9.9. Carbon nanotubes
9.10. Dendrimers
9.11. Nanoemulsion
9.12. Micelles
9.13. Hydrogels
9.14. Nanofibers
9.15. Challenges and future perspectives
Chapter 10. Biofabrication techniques for neural tissue engineering
10.1. Introduction
10.2. Fabrication techniques
10.3. Materials suitable for conduits networked architecture
10.4. Conclusion and future research
Chapter 11. Stem cells, bioengineering, and 3D scaffolds for neural tissue engineering
11.1. Biomaterials for engineering neural tissue from stem cells
11.2. Microfluidic devices in tissue engineering
11.3. Drug delivery system for engineering neural tissue from stem cells
11.4. Extracellular matrix-derived tissues for neurological tissue engineering
11.5. Functionalization of self-assembling peptides for neural tissue engineering
11.6. New technologies for engineering neural tissue from stem cells
11.7. Generation of neural organoids from stem cells and genome editing for engineering neural tissue
Chapter 12. Characterization of scaffolds for neural tissue engineering
12.1. Introduction
12.2. Neural tissue engineering
12.3. Ideal properties of scaffolds for forming neural scaffolds
12.4. Methods for fabrication of neural scaffolds
12.5. Characterization techniques of scaffolds
12.6. Concluding remarks and future directions
Chapter 13. In vitro evaluation of biomaterials for neural tissue engineering
13.1. Introduction
13.2. The nervous system: cell biology
13.3. In vitro studies using biomaterials for neural tissue engineering
Chapter 14. In vivo evaluation of biomaterials for neural tissue engineering
14.1. Realizing the problem and analyzing it comprehensively
14.2. Neural tissue engineering perspective in tissue engineering therapies
14.3. Regeneration of peripheral and central nervous system
14.4. In vitro and in vivo experiments
14.5. Animal choice
14.6. In vivo testing
14.7. Euthanasia
14.8. Evaluation of the results
14.9. Regulations
Index

Oguzhan Gunduz

Dr. Oguzhan Gunduz is Director in Center for Nanotechnology & Biomaterials Applications and Research (NBUAM) at Marmara University. He obtained his PhD thesis in Biomaterials & Tissue Engineering at UCL under supervisor Prof. Dr. Mohan Edirisinghe in 2013. He leads an internationally high-profile multidisciplinary research group focussed on biomaterials, tissue engineering and regenerative medicine. This translational work includes the construction of artificial tissues for repairing and regenerative medicine, developing novel functional scaffolds, drug and nanomaterials therapies for soft and hard tissues, neural repair and protection, and construction of advanced 3D scaffolds with using 3D bioprinting, microfluidics, and electrospinning methods. Research is underpinned by strong productive Turkey and international collaborations resulting in number of 135 scientific papers and 6 book chapters including Elsevier and Springer publisher. He also published more than 150 conference papers.

Affiliations and expertise

Director, Center for Nanotechnology and Biomaterials Applications and Research (NBUAM), Marmara University, Istanbul, Turkey

Cem Bulent Ustundag

Dr. Cem Bülent Ustundag is an Associate Professor in Bioengineering department at Yildiz Technical University. He received B.Sc. degree in Ceramic Engineering from Dumlupinar University, Turkey, in 1999, and M.Sc. in Materials Science & Engineering from Gebze Technical University in 2003 and he has dual Ph.D., in Materials Science & Engineering from Yildiz Technical University (YTU), Turkey in 2011 and Biomaterials from Tohoku University, Japan, in 2013. The research interests of Dr. Ustundag include the development of nanomaterials for biomedical applications, synthesis, and applications of graphene and carbonaceous nanomaterials, nanocomposites, hard/soft tissue scaffolds, 3D printing, and nanomaterials for environmental remediation. He has authored/coauthored over 20 research papers, 3 patents and 10 patent applications, and over 100 national and international conference papers. In addition, he is consulting with Spinamer Inc. on the development of novel biomaterials and collaborating with Biosertaech Inc., Nanortepedi Inc. generic Inc., and MITEC Inc on the nanomaterials, tissue engineering, and drug delivery systems. He is an organizing committee member of the International Congress on 3D Printing (Additive Manufacturing) Technologies and Digital Industry Congress series (2018, 2019, and 2020) and also an advisory board member of International Journal of 3D Printing Technologies and Digital Industry. Dr. Ustundag joined YTU Vocational School and promoted assistant professorship in 2005 and 2011, respectively. He held the UNIDO Technology Foresight Diploma in 2008. From 2010-2012, Dr. Ustundag served as the Head of Ceramic Program and was named the Head of Technical Programs Department (9 technical programs and over 1200 students) at YTU Vocational School and was Vice Manager of YTU Vocational School 2012-2013 and 2013-2014, respectively. Dr. Ustundag led the Establishment Commission of Faculty of Applied Science, YTU in 2013-2014. He held a visiting scholar position at the Department of Chemical and Biological Engineering, Princeton University, NJ, 2014-2015. He joined to Department of Bioengineering, YTU in April 2015. Dr. Ustundag promoted to associate professorship in Bioengineering in 2017. During BSc and MSc, Dr. Ustundag was awarded an education scholarship from Kaleseramik (The largest ceramic company of Turkey) and Ibrahim Bodur Foundation. He received RONPAKU awards of Japan Society for the Promotion of Science (JSPS) 2009. Dr. Ustundag is the recipient of the JSPS Ronpaku Medal in 2013. He was awarded the postdoctoral scholarship from TUBITAK and Princeton University in 2014.

Affiliations and expertise

Associate Professor, Bioengineering Department, Yıldız Technical University, Istanbul, Turkey

Mustafa Sengor

Dr. Mustafa Sengor is an Assistant Professor at Marmara University, Istanbul Turkey. He graduated from the Mechanical Engineering Department of Boğaziçi University in 2010, and completed his master’s degree program at Boğaziçi University in 2013. He received the title of Doctor in 2019 with his thesis titled "Core – Shell Pva / Gelatin Nanofibrous Scaffolds Using Multinozzle Aqueous Electrospinning". He continued to his studies on biomaterials, hydrogels, electrospinning, nanotechnology, and three-dimensional writing technology. He has been studying in medical device research and development. Currently, he is an Assistant Professor in Marmara University and working in Nanotechnology and Biomaterials Application and Research Center (NBUAM) as Deputy Director.

Affiliations and expertise

Assistant Professor, Marmara University, Istanbul, Turkey