Despite advances in materials and sterilisation, patients who receive biomaterials of medical device implants are still at risk of developing an infection around the implantation site. This book reviews the fundamentals of biomaterials and medical device related infections and methods and materials for the treatment and prevention of infection. The first part of the book provides readers with an introduction to the topic including analyses of biofilms, diagnosis and treatment of infection, pathology and topography. The second part of the book discusses a range of established and novel technologies and materials which have been designed to prevent infection.
Provides analysis of biofilms and their relevance to implant associated infections.
Assesses technologies for controlling biofilms.
Considers advantages and disadvantages of in vivo infection studies.
Materials scientists and engineers concerned with producing infection resistant/antimicrobial materials, microbiologists and orthopaedic clinicians.
Table of Contents
List of contributors
Woodhead Publishing Series in Biomaterials
Part One: Introduction to biomaterials and medical device-related infections
1: Introduction to biomaterials and medical device-associated infections
1.1 History of biomaterials
1.2 Overview of current medical devices and applications
1.3 Overview of problems associated with medical devices
1.4 Introduction to the structure of this book
2: Biofilms and implant-associated infections
2.2 Microbial profile of implant-associated infections
2.3 Relevance of biofilms in implant-associated infections
2.4 Structure and composition of biofilms
2.5 Pathogenesis of biofilm infection
2.6 Future trends
2.7 Further information and advice
3: In vivo infection studies
3.2 Legitimacy of animal studies
3.3 Choosing the right animal model to study device-associated infections
3.4 Pros and cons of in vivo infection studies
3.5 Correlation of outcome between animal and clinical studies
3.6 Conclusion and future trends
3.7 Sources of further information and advice
4: Diagnosis of biofilm-associated infections in medical devices
4.2 Importance of detection of biofilm
4.3 Sites of biofilm formation
4.4 Collection of samples for biofilm detection
4.5 Examples of methods for the detection of biofilms associated with infections
4.6 Future trends
5: Diagnosis and treatment of implant-associated infections