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Biomarkers in Toxicology - 2nd Edition - ISBN: 9780128146552, 9780128146569

Biomarkers in Toxicology

2nd Edition

Editor: Ramesh Gupta
eBook ISBN: 9780128146569
Hardcover ISBN: 9780128146552
Imprint: Academic Press
Published Date: 13th February 2019
Page Count: 1246
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Biomarkers in Toxicology, Second Edition, is a timely and comprehensive reference dedicated to all aspects of biomarkers that relate to chemical exposure and their effects on biological systems. This revised and completely updated edition includes both vertebrate and non-vertebrate species models for toxicological testing and the development of biomarkers. Divided into several key sections, this reference volume contains new chapters devoted to topics in microplastics, neuroimmunotoxicity and nutraceuticals, along with a look at the latest cutting-edge technologies used to detect biomarkers. Each chapter contains several references to current literature and important resources for further reading.

Given this comprehensive treatment, this book is an essential reference for anyone interested in biomarkers across the scientific and biomedical fields.

Key Features

  • Evaluates the expansive literature, providing one resource covering all aspects of toxicology biomarkers
  • Includes completely revised chapters, along with additional chapters on the newest developments in the field
  • Identifies and discusses the most sensitive, accurate, unique and validated biomarkers used as indicators of exposure
  • Covers special topics and applications of biomarkers, including chapters on molecular toxicology biomarkers, biomarker analysis for nanotoxicology, development of biomarkers for drug efficacy evaluation, and much more


Toxicologists, pharmacologists, biotechnologists, biologists, health professionals, environmental health specialists, and biomedical researchers in academic, industry and regulatory settings

Table of Contents

Part I. Toxicity Testing Models and Biomarkers
1. Introduction
2. Rodent Models for Toxicity Testing and Biomarkers
3. The Göttingen Minipig as large animal model in toxicology
4. Nonhuman primates in preclinical research
5. Biomarkers of toxicity in zebrafish
6. Mechanistic Toxicology Biomarkers in Caenorhabditis elegans
7. Drosophila melanogaster, Eisenia fetida, and Daphnia magna for toxicity testing and Biomarkers
8. Alternative animal toxicity testing and biomarkers
9. Adverse outcome pathways and biomarkers

Part II. Systems Toxicity Biomarkers
10. Central nervous system toxicity biomarkers
11. Peripheral nervous system toxicity biomarkers
12. Cardiovascular toxicity biomarkers
13. Respiratory toxicity biomarkers
14. Hepatic toxicity biomarkers
15. Conventional and emerging renal biomarkers
16. Gastrointestinal toxicity biomarkers
17. Reproductive toxicity biomarkers
18. Biomarkers of toxicity in human placenta
19. Early Biomarkers of Acute and Chronic Pancreatitis
20. Skeletal muscle toxicity biomarkers
21. Ocular biomarkers in diseases and toxicities
22. Biomarkers of Ototoxicity
23. Blood and bone marrow toxicity biomarkers
24. Immunotoxicity biomarkers

Part III. Chemical Agents, Solvents and Gases Toxicity Biomarkers
25. Bisphenol A (BPA) Biomarkers and Biomonitoring
26. Insecticides
27. Herbicides and fungicides
28. Polychlorinated biphenyls, polybrominated biphenyls, and brominated flame retardants
29. Polycyclic aromatic hydrocarbons
30. Metals
31. Melamine
32. Biomarkers of petroleum products toxicity
33. Biomarkers of chemical mixture toxicity
34. Biomarkers of toxic solvents and gases

Part IV. Biotoxins Biomarkers
35. Freshwater cyanotoxins
36. Mycotoxins
37. Poisonous plants: biomarkers for diagnosis

Part V. Pharmaceuticals and Nutraceuticals Biomarkers
38. Biomarkers of drug toxicity and safety evaluation
39. Risk Assessment, Regulation and the Role of Biomarkers for the Evaluation of Dietary Ingredients present in Dietary Supplements
40. Nutriphenomics in rodent models: Impact of dietary choices on toxicological biomarkers

Part VI. Nanomaterials and Radiation
41. Engineered nanomaterials: Biomarkers of exposure and effect
42. Biomarkers of Exposure and Responses to Ionizing Radiation

Part VII. Carcinogens Biomonitoring and Cancer Biomarkers
43. Biomonitoring exposures to carcinogens
44. Genotoxicity biomarkers: Molecular basis of genetic variability and susceptibility
45. Epigenetic biomarkers in toxicology
46. Breast cancer biomarkers
47. Pancreatic and ovarian cancer biomarkers
48. Prostate cancer biomarkers

Part VIII. Disease Biomarkers
49. Biomarkers of Alzheimer’s disease
50. Biomarkers of Parkinson’s disease
51. Biomarkers for drugs of abuse and neuropsychiatric disorders: Models and mechanisms
52. Osteoarthritis biomarkers
53. Pathological biomarkers in toxicology
54. Oral pathology biomarkers

Part IX. Special Topics
55. Biomarkers of mitochondrial dysfunction and toxicity
56. Biomarkers of blood-brain barrier dysfunction
57. Biomarkers of oxidative/nitrosative stress and neurotoxicity
58. Cytoskeletal disruption as a biomarker of developmental neurotoxicity
59. Membrane transporters and transporter substrates as biomarkers for drug pharmacokinetics, pharmacodynamics, and toxicity/adverse events
60. Citrulline: Pharmacological perspectives and role as a biomarker in diseases and toxicities

Part X. Applications of Biomarkers in Toxicology
61. Analysis of toxin- and toxicant-induced biomarker signatures using microarrays
62. Biomarkers detection for toxicity testing using metabolomics
63. Transcriptomic biomarkers in safety and risk assessment of chemicals
64. Percellome toxicogenomics project as a source of biomarkers of chemical toxicity
65. Proteomics in biomarkers of chemical toxicity
66. Biomarkers for Testing Toxicity and Monitoring Exposure to Xenobiotics
67. Biomarkers in epidemiology, risk assessment and regulatory toxicology


No. of pages:
© Academic Press 2019
13th February 2019
Academic Press
eBook ISBN:
Hardcover ISBN:

About the Editor

Ramesh Gupta

Dr. Ramesh C. Gupta, Professor & Head of Toxicology Department at Murray State university, is engaged in experimental brain research in relation to Alzheimer’s disease (AD) and pesticide toxicity. He has delivered lectures in Australia, Italy, Japan, Germany, France, Switzerland, Spain, Czech Republic, China, South Korea, and Sweden. He served the panels of NIH, CDC, NIOSH, and NAS. He has >350 publications to his credit, including seven major books with Elsevier: (1) Toxicology of Organophosphate and Carbamate Compounds, (2) Veterinary Toxicology: Basic and Clinical Principles, (3) Handbook of Toxicology of Chemical Warfare Agents, (4) Anticholinesterase Pesticides: Metabolism, Neurotoxicity, and Epidemiology, (5) Reproductive and Developmental Toxicology, (6) Biomarkers in Toxicology and (7) Neutraceuticals. He is recipient of Murray State University's distinguished researcher award of the year-2006. He is a diplomate of American Board of Toxicology, and fellow of American College of Toxicology, American College of Nutrition, and Academy of Toxicological Sciences.

Affiliations and Expertise

Professor and Head, Toxicology Department, Breathitt Veterinary Center, Murray State University, Hopkinsville, KY, USA

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