Biomarkers in Toxicology

Biomarkers in Toxicology

2nd Edition - February 13, 2019

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  • Editor: Ramesh C Gupta
  • eBook ISBN: 9780128146569
  • Hardcover ISBN: 9780128146552

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Biomarkers in Toxicology, Second Edition, is a timely and comprehensive reference dedicated to all aspects of biomarkers that relate to chemical exposure and their effects on biological systems. This revised and completely updated edition includes both vertebrate and non-vertebrate species models for toxicological testing and the development of biomarkers. Divided into several key sections, this reference volume contains new chapters devoted to topics in microplastics, neuroimmunotoxicity and nutraceuticals, along with a look at the latest cutting-edge technologies used to detect biomarkers. Each chapter contains several references to current literature and important resources for further reading. Given this comprehensive treatment, this book is an essential reference for anyone interested in biomarkers across the scientific and biomedical fields.

Key Features

  • Evaluates the expansive literature, providing one resource covering all aspects of toxicology biomarkers
  • Includes completely revised chapters, along with additional chapters on the newest developments in the field
  • Identifies and discusses the most sensitive, accurate, unique and validated biomarkers used as indicators of exposure
  • Covers special topics and applications of biomarkers, including chapters on molecular toxicology biomarkers, biomarker analysis for nanotoxicology, development of biomarkers for drug efficacy evaluation, and much more


Toxicologists, pharmacologists, biotechnologists, biologists, health professionals, environmental health specialists, and biomedical researchers in academic, industry and regulatory settings

Table of Contents

  • Part I. Toxicity Testing Models and Biomarkers
    1. Introduction
    2. Rodent Models for Toxicity Testing and Biomarkers
    3. The Göttingen Minipig as large animal model in toxicology
    4. Nonhuman primates in preclinical research
    5. Biomarkers of toxicity in zebrafish
    6. Mechanistic Toxicology Biomarkers in Caenorhabditis elegans
    7. Drosophila melanogaster, Eisenia fetida, and Daphnia magna for toxicity testing and Biomarkers
    8. Alternative animal toxicity testing and biomarkers
    9. Adverse outcome pathways and biomarkers

    Part II. Systems Toxicity Biomarkers
    10. Central nervous system toxicity biomarkers
    11. Peripheral nervous system toxicity biomarkers
    12. Cardiovascular toxicity biomarkers
    13. Respiratory toxicity biomarkers
    14. Hepatic toxicity biomarkers
    15. Conventional and emerging renal biomarkers
    16. Gastrointestinal toxicity biomarkers
    17. Reproductive toxicity biomarkers
    18. Biomarkers of toxicity in human placenta
    19. Early Biomarkers of Acute and Chronic Pancreatitis
    20. Skeletal muscle toxicity biomarkers
    21. Ocular biomarkers in diseases and toxicities
    22. Biomarkers of Ototoxicity
    23. Blood and bone marrow toxicity biomarkers
    24. Immunotoxicity biomarkers

    Part III. Chemical Agents, Solvents and Gases Toxicity Biomarkers
    25. Bisphenol A (BPA) Biomarkers and Biomonitoring
    26. Insecticides
    27. Herbicides and fungicides
    28. Polychlorinated biphenyls, polybrominated biphenyls, and brominated flame retardants
    29. Polycyclic aromatic hydrocarbons
    30. Metals
    31. Melamine
    32. Biomarkers of petroleum products toxicity
    33. Biomarkers of chemical mixture toxicity
    34. Biomarkers of toxic solvents and gases

    Part IV. Biotoxins Biomarkers
    35. Freshwater cyanotoxins
    36. Mycotoxins
    37. Poisonous plants: biomarkers for diagnosis

    Part V. Pharmaceuticals and Nutraceuticals Biomarkers
    38. Biomarkers of drug toxicity and safety evaluation
    39. Risk Assessment, Regulation and the Role of Biomarkers for the Evaluation of Dietary Ingredients present in Dietary Supplements
    40. Nutriphenomics in rodent models: Impact of dietary choices on toxicological biomarkers

    Part VI. Nanomaterials and Radiation
    41. Engineered nanomaterials: Biomarkers of exposure and effect
    42. Biomarkers of Exposure and Responses to Ionizing Radiation

    Part VII. Carcinogens Biomonitoring and Cancer Biomarkers
    43. Biomonitoring exposures to carcinogens
    44. Genotoxicity biomarkers: Molecular basis of genetic variability and susceptibility
    45. Epigenetic biomarkers in toxicology
    46. Breast cancer biomarkers
    47. Pancreatic and ovarian cancer biomarkers
    48. Prostate cancer biomarkers

    Part VIII. Disease Biomarkers
    49. Biomarkers of Alzheimer’s disease
    50. Biomarkers of Parkinson’s disease
    51. Biomarkers for drugs of abuse and neuropsychiatric disorders: Models and mechanisms
    52. Osteoarthritis biomarkers
    53. Pathological biomarkers in toxicology
    54. Oral pathology biomarkers

    Part IX. Special Topics
    55. Biomarkers of mitochondrial dysfunction and toxicity
    56. Biomarkers of blood-brain barrier dysfunction
    57. Biomarkers of oxidative/nitrosative stress and neurotoxicity
    58. Cytoskeletal disruption as a biomarker of developmental neurotoxicity
    59. Membrane transporters and transporter substrates as biomarkers for drug pharmacokinetics, pharmacodynamics, and toxicity/adverse events
    60. Citrulline: Pharmacological perspectives and role as a biomarker in diseases and toxicities

    Part X. Applications of Biomarkers in Toxicology
    61. Analysis of toxin- and toxicant-induced biomarker signatures using microarrays
    62. Biomarkers detection for toxicity testing using metabolomics
    63. Transcriptomic biomarkers in safety and risk assessment of chemicals
    64. Percellome toxicogenomics project as a source of biomarkers of chemical toxicity
    65. Proteomics in biomarkers of chemical toxicity
    66. Biomarkers for Testing Toxicity and Monitoring Exposure to Xenobiotics
    67. Biomarkers in epidemiology, risk assessment and regulatory toxicology

Product details

  • No. of pages: 1246
  • Language: English
  • Copyright: © Academic Press 2019
  • Published: February 13, 2019
  • Imprint: Academic Press
  • eBook ISBN: 9780128146569
  • Hardcover ISBN: 9780128146552

About the Editor

Ramesh C Gupta

Ramesh C Gupta
Dr. Ramesh C. Gupta, Professor & Head of Toxicology Department at Murray State university, is engaged in experimental brain research in relation to Alzheimer’s disease (AD) and pesticide toxicity. He has delivered lectures in Australia, Italy, Japan, Germany, France, Switzerland, Spain, Czech Republic, China, South Korea, and Sweden. He served the panels of NIH, CDC, NIOSH, and NAS. He has >350 publications to his credit, including seven major books with Elsevier: (1) Toxicology of Organophosphate and Carbamate Compounds, (2) Veterinary Toxicology: Basic and Clinical Principles, (3) Handbook of Toxicology of Chemical Warfare Agents, (4) Anticholinesterase Pesticides: Metabolism, Neurotoxicity, and Epidemiology, (5) Reproductive and Developmental Toxicology, (6) Biomarkers in Toxicology and (7) Neutraceuticals. He is recipient of Murray State University's distinguished researcher award of the year-2006. He is a diplomate of American Board of Toxicology, and fellow of American College of Toxicology, American College of Nutrition, and Academy of Toxicological Sciences.

Affiliations and Expertise

Professor and Head, Toxicology Department, Breathitt Veterinary Center, Murray State University, Hopkinsville, KY, USA

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