Biological Inorganic Chemistry

2nd Edition

A New Introduction to Molecular Structure and Function

Print ISBN: 9780444537829
eBook ISBN: 9780444537836
Imprint: Elsevier
Published Date: 2nd February 2012
Page Count: 472
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56.99 + applicable tax
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The revised and expanded second edition of Biological Inorganic Chemistry, winner of a 2013 Texty Award from the Text and Academic Authors Association, presents an introduction to this exciting and dynamic field. An increasing understanding of the importance of metals in biology, the environment and medicine, and the multiple roles of metal ions in biological systems, has given rise to biological inorganic chemistry as a field of study.

The book begins with an overview of the concepts, both chemical and biological, required for the detailed analysis which follows. Pathways of metal assimilation, storage and transport, as well as metal homeostasis, are dealt with next. Thereafter, individual chapters discuss the roles of sodium and potassium, magnesium, calcium, zinc, iron, copper, nickel and cobalt, manganese, and finally molybdenum, vanadium, tungsten, chromium and selected non-metals. The final five chapters provide a tantalizing view of the roles of metals in brain function, biomineralization, and a brief illustration of their importance in both medicine and the environment.

Table of Contents


Chapter 1. An Overview of Metals and Selected Nonmetals in Biology


Why do We Need Anything Other Than C, H, N, and O (together with some P and S)?

What are the Essential Elements and the Essential Metal Ions?

An Idiosyncratic View of the Periodic Table

Chapter 2. Basic Coordination Chemistry for Biologists


Types of Chemical Bonds

Hard and Soft Ligands

Coordination Geometry

Redox Chemistry

Chapter 3. Structural and Molecular Biology for Chemists


The Structural Building Blocks of Proteins

Primary, Secondary, Tertiary, and Quaternary Structure of Proteins

Secondary and Tertiary Structures of Nucleic Acids

Chapter 4. Biological Ligands for Metal Ions


Insertion of Metal Ions into Metalloproteins

Chelatase – The Terminal Step in Tetrapyrrole Metallation

Iron–Sulfur Cluster Formation

More Complex Cofactors – MoCo, FeMoCo, P-clusters, H-clusters, and CuZ


Chapter 5. An Overview of Intermediary Metabolism and Bioenergetics


Redox Reactions in Metabolism

The Central Role of ATP in Metabolism

The Types of Reaction Catalysed by Enzymes of Intermediary Metabolism

An Overview of Catabolism

Selected Case Studies – Glycolysis and the Tricarboxylic Acid Cycle

An Overview of Anabolism

Selected Case Studies: Gluconeogenesis and Fatty Acid Biosynthesis

Bioenergetics – Generation of Phosphoryl Transfer Potential at the Expense of Proton Gradients

Chapter 6. Methods to Study Metals in Biological Systems


Magnetic Properties

Electron Paramagnetic Resonance (EPR) Spectroscopy

Mössbauer Spectroscopy

NMR Spectroscopy

Electronic and Vibrational Spectroscopies

Circular Dichroism


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© Elsevier 2012
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2013 Textbook Excellence Awards (Texty), Text and Academic Authors Association


"…a fine scholarly text written in a reader-friendly style to describe the various roles of metals in biological systems, human health, and the environment. It also considers the mechanisms and experimental methods for studying biological processes involving metals…I would highly recommend it to all interested biology, and biochemistry students and researchers."--Science Progress, vol 97, issue 1, 2014
"…a fine scholarly text written in a reader-friendly style to describe the various roles of metals in biological systems, human health, and the environment…The material of the second edition of this book has been updated, and new chapters have been included…I would highly recommend it to all interested biology, and biochemistry students and researchers."--Science Progress, February 18, 2014
"Crichton…offers this detailed and extensively illustrated text on inorganic components of biochemistry. Three introductory chapters explain the basic importance of metals in biology and orient biologists to coordination chemistry and chemists to molecular biology, respectively. General features of metal function are covered, including common ligands, their role in metabolism, assimilation and transport, and methods of study."--Reference & Research Book News, December 2013
"At first blush, inorganic biochemistry might sound like an oxymoron, but that is not the case here…Crichton’s book will be useful resource for students or researchers who want to understand the exciting world of inorganic biochemistry."--CHOICE, October 2012, Vol. 50, No. 02
"Robert Crichton has blended an element-centric approach to the subject with a biological thread that is engaging and helpful in exploring the topics in detail. The text is both accessible and detailed, but pitched at undergraduate level."--Chemistry World<