Biogenesis of Antibiotic Substances - 1st Edition - ISBN: 9780123955241, 9780323155830

Biogenesis of Antibiotic Substances

1st Edition

Editors: Zdenko Vanek
eBook ISBN: 9780323155830
Imprint: Academic Press
Published Date: 1st January 1965
Page Count: 324
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Biogenesis of Antibiotic Substances covers the proceedings of a panel discussion on ""Basic Research and Practical Aspects of Antibiotic Production"" held during the Antibiotic Congress in Prague. This book is organized into 25 chapters that cover the regulating mechanisms of primary antibiotic metabolite biosynthesis. This text describes the relationship between secondary metabolite production and synthesis of cell matter or cell wall.
The opening chapters describe the parasexual cycle and some of the ways in which the cycle may be used for strain improvement, as well as the applications of refined techniques of genetic recombination and the principles of biochemical genetics to the field of antibiotics. The next chapter deals with cultural and fermentative characteristics of A-type isolates obtained from progenitor and representative member strains of the Wisconsin Family of Strains of Penicillium chrysogenum. Considerable chapters are devoted to the metabolite biosynthesis, such as geodoxin and related compounds; secondary metabolism of penicillins, gibberellins, and griseofulvin in fungi; and tetracycline metabolites. The book goes on examining the stereochemical aspects of macrolide antibiotics. It also describes the biosynthetic pathways involving ring cleavage of carbocyclic compounds, as well as the biosynthesis of different peptide antibiotics and of actinomycins and its relationship to protein synthesis. The production of phenazines is also explained. Other chapters consider other metabolites, such as those that decarboxylate, the malonate, and the 3-nitropropionic acid. A discussion on the role of carbohydrates and phosphate in the biosynthesis of different types of antibiotics is included. Lastly, microbiological assay procedures for antibiotic research and influencing factors are presented.

Table of Contents



Chapter 1 About Mechanisms Regulating the Biosynthesis of Secondary Metabolites

Chapter 2 Fungal Genetics and Strain Improvement

Chapter 3 Possible Applications of Formal and Biochemical Genetics to the Field of Antibiotics

Chapter 4 On the Basic Trend of Genetical Studies and Breeding Program of Antibiotic-Producing Organisms

Chapter 5 The A-Type Variant Colony of Penicillium chrysogenum Strains and Antibiotic Production

Chapter 6 The Biosynthesis of Geodoxin and Related Compounds

Chapter 7 Aspects of Secondary Metabolism in Fungi

Chapter 8 Biosynthesis of the Tetracyclines

Chapter 9 The Carbohydrate Metabolism of Producing Microorganisms and the Biosynthesis of Tetracycline Antibiotics

Chapter 10 Basic Stereochemical Research Topics in the Macrolide Antibiotics

Chapter 11 Speculation on the Origin of Macrolide Antibiotics

Chapter 12 Reflections on the Fungal Formation of Acetate-Derived Metabolites

Chapter 13 Biosynthetic Pathways Involving Ring Cleavage

Chapter 14 Problems Relating to the Biosynthesis of Peptide Antibiotics

Chapter 15 The Biosynthesis of the Actinomycins and its Relationship to Protein Synthesis

Chapter 16 The Production of the Phenazines by Actinomycetes

Chapter 17 Amino- and Nitrobenzoic Acid Metabolism in Actinomycetes and Its Influence on Synthesis of Antibiotics

Chapter 18 The Role of Decarboxylation in the Secondary Metabolism of Molds

Chapter 19 Studies on the Basic Metabolism Determining the Biosynthesis of Malonate Derived Compounds in Penicillium islandicum

Chapter 20 Origin of 3-Nitropropionic Acid in Fungi

Chapter 21 A Mechanism of Energy Control on the Biosynthesis of Hydroxystreptomycin

Chapter 22 Comments on the General Role of Carbohydrates in Antibiotic Synthesis

Chapter 23 Microbiological Assay Procedures for Special Problems in Antibiotic Research

Chapter 24 Empiricism in the Determination of Preferred Metabolic Conditions

Chapter 25 Discussion

Author Index

Microorganism Index

Compound Index

Subject Index


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© Academic Press 1965
Academic Press
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Zdenko Vanek

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