Biofabrication

Biofabrication

Micro- and Nano-fabrication, Printing, Patterning and Assemblies

1st Edition - March 18, 2013

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  • Editors: Gabor Forgacs, Wei Sun
  • eBook ISBN: 9781455730049
  • Hardcover ISBN: 9781455728527

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Description

Biofabrication is a practical guide to the novel, inherently cross-disciplinary scientific field that focuses on biomanufacturing processes and a related range of emerging technologies. These processes and technologies ultimately further the development of products that may involve living (cells and/or tissues) and nonliving (bio-supportive proteins, scaffolds) components. The book introduces readers to cell printing, patterning, assembling, 3D scaffold fabrication, cell/tissue-on-chips as a coherent micro-/nano-fabrication toolkit. Real-world examples illustrate how to apply biofabrication techniques in areas such as regenerative medicine, pharmaceuticals and tissue engineering. In addition to being a vital reference for scientists, engineers and technicians seeking to apply biofabrication techniques, this book also provides an insight into future developments in the field, and potential new applications.

Key Features

  • Discover the multi-disciplinary toolkit provided by biofabrication and apply it to develop new products, techniques and therapies
  • Covers a range of important emerging technologies in a coherent manner: cell printing, patterning, assembling, 3D scaffold fabrication, cell/tissue-on-chips...
  • Readers develop the ability to apply biofabrication technologies through practical examples

Readership

R&D teams, researchers and

scientists in the fields of

Bioengineering / Biomaterials /

Biofabrication / Biomedical

Engineering / Tissue Engineering;

Regenerative Medicine,

Biotechnology, Pharmaceuticals,

Mechanical Engineering.

Engineers and Industrial scientists at

pharmaceutical companies, biotech

companies, medical device

companies.

Biotechnologists and Process

E

Table of Contents

  • Preface

    List of Contributors

    Chapter 1. In Vitro Biofabrication of Tissues and Organs

    Introduction

    1.1 Problems with scaffold-based tissue engineering

    1.2 “Scaffold-free” tissue engineering

    1.3 Aggregation/spheroid-based approaches

    Conclusion

    References

    Chapter 2. Biomaterials for Biofabrication of 3D Tissue Scaffolds

    Introduction

    2.1 Materials for 3D tissue scaffolds

    2.2 Fabrication methods for 3D tissue scaffolds

    2.3 Application of 3D tissue scaffolds

    2.4 Future perspectives of biomaterials for 3D scaffolds

    Conclusion

    Acknowledgment

    References

    Chapter 3. Projection Printing of Three-Dimensional Tissue Scaffolds with Tunable Poisson’s Ratio

    Introduction

    3.1 Digital micromirror-assisted projection printing stereolithography

    3.2 Negative Poisson’s ratio biomaterials

    3.3 Hybrid Poisson’s ratio biomaterial

    3.4 Zero Poisson’s ratio biomaterials

    Conclusion

    References

    Chapter 4. Fabrication of Microscale Hydrogels for Tissue Engineering Applications

    Introduction

    4.1 Technologies for fabrication of microengineered hydrogels

    4.2 Tissue engineering applications

    Conclusion

    Acknowledgments

    References

    Chapter 5. Polymeric Membranes for the Biofabrication of Tissues and Organs

    Introduction

    5.1 Properties of polymeric membranes

    5.2 Membranes for tissue engineering

    5.3 Hollow fiber polymeric membranes for cell and tissue perfusion

    5.4 Membrane bioreactors for tissue constructs

    5.5 Future perspectives

    References

    Chapter 6. Laser-Assisted Bioprinting for Tissue Engineering

    Introduction

    6.1 LAB’s terms of reference

    6.2 LAB parameters for cell printing

    6.3 High-resolution/high-throughput trade-offs

    6.4 Three-dimensional printing: the layer-by-layer approach

    6.5 Applications

    Conclusion

    Acknowledgments

    References

    Further Reading

    Chapter 7. The Modular Approach

    Introduction

    7.1 Materials used to fabricate the modular building blocks

    7.2 Intrinsically vascularized tissue constructs

    7.3 Building tissue constructs by assembling building blocks

    7.4 Modular tissue engineering combined with microfluidics

    Conclusion

    References

    Chapter 8. Formation of Multicellular Microtissues and Applications in Biofabrication

    Introduction

    8.1 Materials and methods

    8.2 Results

    8.3 Discussion

    8.4 Future considerations

    References

    Chapter 9. A Digital Microfabrication-Based System for the Fabrication of Cancerous Tissue Models

    Introduction

    9.1 Digital micro-mirroring microfabrication system

    9.2 Multinozzle biologics deposition system

    9.3 Methods and materials

    9.4 Results

    Conclusion

    References

    Chapter 10. Breast Reconstruction Using Biofabrication-Based Tissue Engineering Strategies

    Introduction

    10.1 Anatomy of the breast

    10.2 Current methods of breast reconstruction

    10.3 Biofabrication-based tissue engineering strategy

    Conclusion

    References

    Chapter 11. Fabrication of Artificial Bacteria for Targeted Drug Delivery

    Introduction

    11.1 Drug delivery

    11.2 Bioinspired locomotion and microswimming

    11.3 Materials and methods

    Conclusion

    Acknowledgment

    References

    Chapter 12. Biofabricating the Bio-Device Interface Using Biological Materials and Mechanisms

    Introduction

    12.1 Complementarity of biofabrication and microfabrication

    12.2 Biofabrication methods

    12.3 Biofabrication of a multifunctional matrix

    12.4 Postfabrication biofunctionalization of devices

    12.5 Test device

    12.6 Electroaddressing a biosensing enzyme

    12.7 Creation of a spatially segregated bacterial biofilm

    Conclusion

    Acknowledgment

    References

    Index

Product details

  • No. of pages: 288
  • Language: English
  • Copyright: © William Andrew 2013
  • Published: March 18, 2013
  • Imprint: William Andrew
  • eBook ISBN: 9781455730049
  • Hardcover ISBN: 9781455728527

About the Editors

Gabor Forgacs

Wei Sun

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