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Biochemistry of Smooth Muscle Contraction - 1st Edition - ISBN: 9780120781607, 9780080527895

Biochemistry of Smooth Muscle Contraction

1st Edition

Editor: Michael Barany
Hardcover ISBN: 9780120781607
eBook ISBN: 9780080527895
Imprint: Academic Press
Published Date: 5th December 1995
Page Count: 418
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This valuable resource provides a systematic account of the biochemistry of smooth muscle contraction. As a comprehensive guide to this rapidly growing area of research, it covers the structure and characteristic properties of contractile and regulatory proteins, with special emphasis on their predicted function in the live muscle. Also included in this book are intermediate filament proteins, and desmin and vimentin, whose function in smooth muscle is unknown; and several enzymes involved in the phosphorylation-dephosphorylation of contractile and other proteins.


Basic medical scientists who are using smooth muscle as a research model, clinicians studying the pathology of smooth muscle, drug developers researching drugs to counteract diseases involving smooth muscles, and cell biologists. Also graduate and medical students studying biochemical mechanisms, cell biology, and muscle contraction. Academic cardiologists, OB-GYN, and GI researchers

Table of Contents

Contractile Proteins:
R.S. Adelstein and J.R. Sellers, Myosin Structure and Function.
K. Bereny and M. Bereny, Myosin Light Chains.
K.M. Trybus, Myosin Regulation and Assembly.
W. Lehman, P. Vibert, R. Craig, and M. Bereny, Actin and the Structure of Smooth Muscle Thin Filaments.
Thin Filament and Calcium-Binding Proteins:
L.B. Smilie, Tropomyosin.
S.B. Marston and P.A.J. Huber, Caldesmon.
M. Gimona and J.V. Small, Calponin.
R.S. Mani and C.M. Kay, Calcium Binding Proteins.
Enzymes of Protein Phosphorylation-Dephosphorylation:
J.T. Stull, J.K. Krueger, K.E. Kamm, Z.-H. Gao, G. Zhi, and R. Padre, Myosin Light Chain Kinase.
F. Erdidi, M. Ito, and D.J. Hartshorne, Myosin Light Chain Phosphatase.
H.A. Singer, S.T. Abraham, and C.M. Schworer, Calcium/Calmodulin-Dependent Protein Kinase II.
H.A. Singer, Protein Kinase C.
L.P. Adam, Mitogen-Activated Protein Kinase.
Motile Systems:
J.R. Sellers, In Vitro Motility Assays with Smooth Muscle Myosin.
G. Pfitzer, Permeabilized Smooth Muscle.
Calcium Movements:
H.J. Knot, J.E. Brayden, and M.T. Nelson, Calcium Channels and Potassium Channels.
F. Hofmann and N.Klugbauer, Molecular Biology and Expression of Smooth Muscle L-Type Calcium Channels.
C.M. Rembold, Electromechanical and Pharmacomechanical Coupling.
L. Raeymaekers and F. Wuytack, Calcium Pumps.
Signal Transduction:
T.M. Lincoln,T.L. Cornwell, P. Komalavilas, L.A. Macmillan-Crow, and N. Boerth, The Nitric Oxide-Cylic GMP Signaling Systems.
M. Bereny and K. Bereny, Inositol 1, 4, 5-Trisphosphate Production.
J. Di Salvo, N. Kaplan, and L.A. Semenchuk, Protein Tyrosine Phosphorylation and Regulation of Intracellular Calcium in Smooth Muscle Cells.
A. Galione and J. Sethi, Cyclic ADP-Ribose and Calcium Signaling.
R.A. Khalil and K.G. Morgan, Enzyme Translocations during Smooth Muscle Activation.
Contraction and Relaxation:
M. Bereny and K. Bereny, Protein Phosphorylation during Contraction and Relaxation.
J.D. Strauss and R.A. Murphy, Regulation Cross-Bridge Cycling in Smooth Muscle.
K.E. Kamm and R.W. Grange, Calcium Sensitivity of Contraction.
P.J. Silver, and D.S. Krafte, Pharmacological Regulation of Smooth Muscle by Ion Channels, Kinases, and Cyclic Nucleotides.
P. Hellstand, Energetics of Smooth Muscle Contraction.
P.F. Dillon, 31P Nuclear Magnetic Resonance Spectroscopy.
Chapter References.
Subject Index.


No. of pages:
© Academic Press 1995
5th December 1995
Academic Press
Hardcover ISBN:
eBook ISBN:

About the Editor

Michael Barany

Affiliations and Expertise

University of Illinois, Chicago, U.S.A.


"...the most substantial and significant collection of reviews of important areas to current understanding of smooth muscle contraction and its regulation to appear for several years... This book is an absolute must for anyone working in the smooth muscle field. It is ideal for students embarking on studies of smooth muscle and will get them up to speed with developments in this field up to approximately mid 1995. I intend to use this book extensively in a postgraduate course on 'Smooth Muscle Structure and Function... My copy is already grubby from regular use!" --Trends in Biochemical Sciences

"Each chapter contains up-to-date information, and perspective sections deal with key unanswered questions. The book provides comprehensive information on most of the important topics in this area...[it] makes a significant contribution to the field and will serve as a valuable reference both for investigators who have been working with smooth muscle and for those about to enter the field."  --Mitsuo Ikebe, University of Massachusetts Medical Center, Science

"This book will be a valuable resource for the research worker knowledge in smooth muscle biochemistry and physiology. The book summarizes nicely the major concepts and provides useful references." --Merrill Tarr, University of Kansas Medical Center, Doodys Health Sciences Journal

"The book delivers more than promised by the title.... Few important aspects of smooth muscle are left uncovered... [Its] multiple personality is split between reference text, introductory monograph, methods handbook, and a compilation of recent developments by specialists. Much in its pages will be of use to those either working or merely interested in the field." --Nature

"This book, edited by one of the most prominent investigators in the field of muscle research, has been designed to offer a comprehensive and up-to-date perspective of smooth muscle contraction. It covers all aspects of the fine structure of the contractile apparatus, signal transduction and regulation by calcium and protein phosphorylation, and the detailed mechanism and energetics of contraction. From the vantage point of an outsider, it has been exciting for me to see how extensively this field has developed. The application of new methodologies, including those of molecular biology, has led to remarkable progress in elucidating the structure and assembly of the contractile machinery, including the complex interactions that take place between contractile elements. This book, illustrates well how far these new technologies have taken us and where they might lead us tomorrow." --Edmond H. Fisher, Nobel Laureate, University of Washington, Seattle

Ratings and Reviews