Biochemistry of Smooth Muscle Contraction

Biochemistry of Smooth Muscle Contraction

1st Edition - December 5, 1995

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  • Editor: Michael Barany
  • Hardcover ISBN: 9780120781607
  • eBook ISBN: 9780080527895

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This valuable resource provides a systematic account of the biochemistry of smooth muscle contraction. As a comprehensive guide to this rapidly growing area of research, it covers the structure and characteristic properties of contractile and regulatory proteins, with special emphasis on their predicted function in the live muscle. Also included in this book are intermediate filament proteins, and desmin and vimentin, whose function in smooth muscle is unknown; and several enzymes involved in the phosphorylation-dephosphorylation of contractile and other proteins.


Basic medical scientists who are using smooth muscle as a research model, clinicians studying the pathology of smooth muscle, drug developers researching drugs to counteract diseases involving smooth muscles, and cell biologists. Also graduate and medical students studying biochemical mechanisms, cell biology, and muscle contraction. Academic cardiologists, OB-GYN, and GI researchers

Table of Contents

  • Contractile Proteins:
    R.S. Adelstein and J.R. Sellers, Myosin Structure and Function.
    K. Bereny and M. Bereny, Myosin Light Chains.
    K.M. Trybus, Myosin Regulation and Assembly.
    W. Lehman, P. Vibert, R. Craig, and M. Bereny, Actin and the Structure of Smooth Muscle Thin Filaments.
    Thin Filament and Calcium-Binding Proteins:
    L.B. Smilie, Tropomyosin.
    S.B. Marston and P.A.J. Huber, Caldesmon.
    M. Gimona and J.V. Small, Calponin.
    R.S. Mani and C.M. Kay, Calcium Binding Proteins.
    Enzymes of Protein Phosphorylation-Dephosphorylation:
    J.T. Stull, J.K. Krueger, K.E. Kamm, Z.-H. Gao, G. Zhi, and R. Padre, Myosin Light Chain Kinase.
    F. Erdidi, M. Ito, and D.J. Hartshorne, Myosin Light Chain Phosphatase.
    H.A. Singer, S.T. Abraham, and C.M. Schworer, Calcium/Calmodulin-Dependent Protein Kinase II.
    H.A. Singer, Protein Kinase C.
    L.P. Adam, Mitogen-Activated Protein Kinase.
    Motile Systems:
    J.R. Sellers, In Vitro Motility Assays with Smooth Muscle Myosin.
    G. Pfitzer, Permeabilized Smooth Muscle.
    Calcium Movements:
    H.J. Knot, J.E. Brayden, and M.T. Nelson, Calcium Channels and Potassium Channels.
    F. Hofmann and N.Klugbauer, Molecular Biology and Expression of Smooth Muscle L-Type Calcium Channels.
    C.M. Rembold, Electromechanical and Pharmacomechanical Coupling.
    L. Raeymaekers and F. Wuytack, Calcium Pumps.
    Signal Transduction:
    T.M. Lincoln,T.L. Cornwell, P. Komalavilas, L.A. Macmillan-Crow, and N. Boerth, The Nitric Oxide-Cylic GMP Signaling Systems.
    M. Bereny and K. Bereny, Inositol 1, 4, 5-Trisphosphate Production.
    J. Di Salvo, N. Kaplan, and L.A. Semenchuk, Protein Tyrosine Phosphorylation and Regulation of Intracellular Calcium in Smooth Muscle Cells.
    A. Galione and J. Sethi, Cyclic ADP-Ribose and Calcium Signaling.
    R.A. Khalil and K.G. Morgan, Enzyme Translocations during Smooth Muscle Activation.
    Contraction and Relaxation:
    M. Bereny and K. Bereny, Protein Phosphorylation during Contraction and Relaxation.
    J.D. Strauss and R.A. Murphy, Regulation Cross-Bridge Cycling in Smooth Muscle.
    K.E. Kamm and R.W. Grange, Calcium Sensitivity of Contraction.
    P.J. Silver, and D.S. Krafte, Pharmacological Regulation of Smooth Muscle by Ion Channels, Kinases, and Cyclic Nucleotides.
    P. Hellstand, Energetics of Smooth Muscle Contraction.
    P.F. Dillon, 31P Nuclear Magnetic Resonance Spectroscopy.
    Chapter References.
    Subject Index.

Product details

  • No. of pages: 418
  • Language: English
  • Copyright: © Academic Press 1995
  • Published: December 5, 1995
  • Imprint: Academic Press
  • Hardcover ISBN: 9780120781607
  • eBook ISBN: 9780080527895

About the Editor

Michael Barany

Affiliations and Expertise

University of Illinois, Chicago, U.S.A.

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