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Research on the biochemistry and molecular biology of lipids and lipoproteins has experienced remarkable growth in the past 20 years, particularly with the realization that many different classes of lipids play fundamental roles in diseases such as heart disease, obesity, diabetes, cancer and neurodegenerative disorders. The 5th edition of this book has been written with two major objectives. The first objective is to provide students and teachers with an advanced up-to-date textbook covering the major areas of current interest in the lipid field. The chapters are written for students and researchers familiar with the general concepts of lipid metabolism but who wish to expand their knowledge in this area. The second objective is to provide a text for scientists who are about to enter the field of lipids, lipoproteins and membranes and who wish to learn more about this area of research. All of the chapters have been extensively updated since the 4th edition appeared in 2002.
- Represents a bridge between the superficial coverage of the lipid field found in basic biochemistry text books and the highly specialized material contained in scientific review articles and monographs
- Allows scientists to become familiar with recent developments related to their own research interests, and will help clinical researchers and medical students keep abreast of developments in basic science that are important for subsequent clinical advances
- Serves as a general reference book for scientists studying lipids, lipoproteins and membranes and as an advanced and up-to-date textbook for teachers and students who are familiar with the basic concepts of lipid biochemistry
Students and researchers in biochemistry, molecular biology, cell biology, genetics, and biophysics
Functional roles of lipids in membranes; Lipid modifications of proteins; Fatty acid and phospholipid metabolism in prokaryotes; Lipid metabolism in plants; Oxidation of fatty acids in eukaryotes; Fatty acid synthesis in eukaryotes; Fatty acid desaturation and chain elongation in eukaryotes; Phospholipid biosynthesis in eukaryotes; Ether-linked lipids and their bioactive species; Adipose tissue and lipid metabolism; Phospholipases; Glycerolipids in signal transduction; The eicosanoids: cyclooxygenase, lipoxygenase, and epoxygenase pathways; Sphingolipids: metabolism and cell signalling; Cholesterol biosynthesis; Metabolism and function of bile acids; Lipid assembly into cell membranes; Lipoprotein structure; Assembly and secretion of lipoproteins; Dynamics of lipoprotein transport in the human circulatory system; Lipoprotein receptors; Lipids and atherosclerosis
- No. of pages:
- © Elsevier Science 2008
- 14th March 2008
- Elsevier Science
- Hardcover ISBN:
- eBook ISBN:
Dr. Neale Ridgway has made his scientific mark nationally and internationally and is a noted world expert in the synthesis, transport and regulation of two of the most abundant and important lipids in the human body – cholesterol and phosphatidylcholine His revelations about the signals and pathways that control these lipids are having a profound impact on our understanding of the origins and progression of such diseases as Alzheimer’s, atherosclerosis, cancer and lipid storage disorders. His groundbreaking work is frequently cited by other scientists in the literature, a key indicator of his influence and achievements.
Departments of Pediatrics and Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, Canada
Dr. McLeod is a lipid researcher and studies how dietary fats are transported, broken down, stored and used in the body – and how different fats can either lead to, or prevent, chronic disease. He’s particularly interested in obesity, type 2 diabetes and cardiovascular disease, related diseases that are skyrocketing, in spite of widespread attempts to counter the deadly trends.
Department of Biochemistry and Molecular Biology, Dalhousie University, Halifax, Nova Scotia, Canada
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