Biochemistry of Cancer

Biochemistry of Cancer

1st Edition - January 1, 1947

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  • Author: Jesse P. Greenstein
  • eBook ISBN: 9781483274249

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Biochemistry of Cancer focuses on cancer research, including induction, chemical composition, and growth of tumors and chemotherapy. The book first offers information on the general phenomena and taxonomy of cancer. Discussions focus on the transmissibility of tumors and experimental basis of cancer research; cancerous transformation of animal tissues in vitro; growth and the vascular reactions of tumors; and classification of animal tumors. The text also ponders on the extrinsic factors in the induction of tumors, including comparative carcinogenicity of hydrocarbons, metabolic fate of injected hydrocarbons, dosage and response to carcinogenic hydrocarbons, and polycyclic hydrocarbons. The manuscript takes a look at the intrinsic factors in the induction of tumors. Topics include influence of sex hormones on carcinogenesis of sex and accessory sex tissues; viruses as causative agents for fowl tumors and rabbit papillomas; and possibility of relatively non-specific endogenous carcinogens. The publication also elaborates on attempts to control tumor induction and growth and the chemistry of tumors. The book is a vital reference for readers interested in the biochemistry of cancer.

Table of Contents

  • Contents

    Chapter I. Introduction — The Oncological Sciences

    Chapter II. The General Phenomena and Taxonomy of Cancer


    Definition and Some Characteristics of Tumors

    Classification of Animal Tumors

    Transmissibility of Tumors and the Experimental Basis of Cancer Research

    Experimental Induction of Tumors

    Cancerous Transformation of Animal Tissues in Vitro

    Growth and the Vascular Reactions of Tumors

    Plant Tumors

    Fish Tumors

    Tissue Immunity Reactions


    The Induction of Tumors

    Chapter III. Extrinsic Factors


    The Carcinogenic Action of Coal Tar

    The Polycyclic Hydrocarbons

    Comparative Carcinogenicity of the Hydrocarbons

    The Relative Susceptibility of Mice Strains to the Polycyclic Hydrocarbons

    Metabolic Fate of Injected Hydrocarbons

    Dosage of and Response to the Carcinogenic Hydrocarbons

    The Influence on Carcinogenicity of Concomitant Materials

    The Azo Dyes

    The Metabolism of p-Dimethylaminoazobenzene

    Halogenated Aliphatic Hydrocarbons


    Ultraviolet Light as a Carcinogenic Agent

    The Effect of Carcinogenic Agents in Various Species

    Relation Between Induced and Spontaneous Tumors

    Environmental Factors as Carcinogenic Agents


    Chapter IV. Intrinsic Factors


    Influence of Sex Hormones on Carcinogenesis of Sex and Accessory Sex Tissues

    Influence of Sex Hormones on Carcinogenesis of Non-Sex Tissues

    The Mammary Tumor Inciter for Mice

    Viruses as Causative Agents for Fowl Tumors and Rabbit Papillomas

    The Possibility of Relatively Non-Specific Endogenous Carcinogens


    Attempts at Control of Tumor Induction and of Tumor Growth

    Chapter V. Nutrition


    Induction of Mammary Tumors in Mice

    Dietary Deficiency and Hormone Inhibition

    Induction of Tumors other than Mammary

    Diet and Different Stages of Carcinogenesis

    Diet and the Established Tumor


    Chapter VI. Endocrinology


    Mammary Tumors in Mice

    Leukemia in Mice

    Carcinoma of the Prostate in Man


    Chapter VII. Chemotherapy


    Bacterial Metabolites

    Benzene and Arsenite

    Radioactive Isotopes



    The Properties of Tumors

    Chapter VIII. Chemistry of Tumors


    Chemical Concentration or Activity and the Proportion of Active Epithelial Cells in Tumors

    The Metabolism of Normal Tissues, of Primary Tumors and of Transplanted Tumors

    The Chemical Pattern of Normal and of Neoplastic Tissues

    General Conclusions

    Conclusions Relating to Special Systems

    The Overall Enzyme Pattern

    The Properties of Homologous Hepatic Tissues

    The Oxidative Response of Normal and Neoplastic Tissues

    Glycolytic Reactions in Normal and Neoplastic Tissues

    Proteins in Normal and Neoplastic Tissues

    Correlation of Metabolism of Normal and Tumor Tissues with Concentration of Crucial Components

    Melanotic and Amelanotic Melanomas

    Strain Differences in Mice

    Tumors and the Problem of Synthesis

    Chemical Constitution of Tumors and the Problem of Therapy


    Chapter IX. Chemistry of the Tumor-bearing Host


    Specific Systems

    Hepatic Dysfunction in Man

    Hepatic, Renal and Blood Catalase Activity

    Hepatic and Renal d-Amino Acid Oxidase

    Hepatic and Renal Arginase

    Hepatic Riboflavin

    Tissue Esterase and Lipase

    Tissue Lipoids and Steroids

    Water Content


    Muscle Nucleophosphatase

    Hepatic Tissue Glycolysis in Leukemia

    Tissue Components of Cancerous Hosts Which Do Not Apparently Alter from Normal

    Hemoglobin Concentration

    Blood Proteose

    Serum Zymohexase

    Plasma Prothrombin

    Serum Phosphatase (Monoesterase)

    Serum Phosphatase Levels in Prostatic Carcinoma

    Serum Alkaline Phosphatase in Neoplastic Involvement of the Liver

    Serum and Blood Esterase and Lipase

    Urinary Steroids

    Summary of Data

    Effect of Serum on Isolated Enzyme Systems

    Bence-Jones Proteins


    Chapter X. The Present Status of the Problem

    Experimental and Clinical Cancer Research

    Author Index

    Subject Index

Product details

  • No. of pages: 398
  • Language: English
  • Copyright: © Academic Press 1947
  • Published: January 1, 1947
  • Imprint: Academic Press
  • eBook ISBN: 9781483274249

About the Author

Jesse P. Greenstein

Affiliations and Expertise

National Cancer Institute, US. Public HealthService, Bethesdu, Maryland

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