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Biochemical Aspects of Reactions on Solid Supports focuses on water-soluble enzyme derivatives and their possible use as heterogeneous specific catalysts in research and industry. It discusses the four fundamental methods used for the preparation of water-insoluble derivatives of biologically active proteins. Organized into five chapters, the book starts by reviewing the methods available for the immobilization of proteins, which includes enzymes adsorption, occlusion in cross-linked polymeric matrices, covalent binding to water-insoluble carriers, and intermolecular cross-linking. It then discusses the principle of affinity chromatography, which can be applied to a wide range of macromolecular-ligand systems. Other chapters consider the developments in the use of solid support and reagents in peptide synthesis. In addition, the book discusses the various methods used in the production of cation-exchange resins for amino acid chromatography and water softening. This book is a valuable resource for biochemists, chemical biologists, scientists, students, and researchers whose interests span a variety of fields.
List of Contributors
Chapter 1. Water-Insoluble Enzyme Derivatives and Artificial Enzyme Membranes
II. Preparation of Water-Insoluble Enzyme Derivatives
III. Stability of Water-Insoluble Enzyme Derivatives
IV. Kinetic Behavior of Particulate Immobilized Enzyme Systems
V. Enzyme Columns
VI. Enzyme Membranes
Chapter 2. Selective Adsorbents Based on Biochemical Specificity
II. Water-Insoluble Carriers
III. Selection of the Ligand
IV. Covalent Linking Reactions
V. Conditions for Chromatography on Affinity Columns
VI. Importance of Anchoring Arms
VII. Specific Adsorbents for Protein Purification
VIII. Specific Nucleic Acid Adsorbents
IX. Isolation of Cells, Receptor Structures, and Other Particulate Cell Structures
Chapter 3. Solid Phase Synthesis: The Use of Solid Supports and Insoluble Reagents in Peptide Synthesis
II. Polymeric Carboxyl Protection
III. Polymeric Amino Protection
IV. Polymeric Side-Chain Protection
V. Polymeric Coupling Reagents
VI. Effects of Physical Properties of Polymeric Supports
VIII. Similar Development in Conventional Synthesis
IX. Difficulties in Analysis
XI. Conclusions and Summary
Chapter 4. Sequential Degradation of Peptides Using Solid Supports
II. Degradation of Peptides Attached to Solid Supports
III. Degradation of Peptides with an Insoluble Reagent
IV. Properties of Resins Important for Peptide Degradations
Chapter 5. Preparation of Cross-Linked Polystyrenes and Their Derivatives for Use as Solid Supports or Insoluble Reagents
II. Types of Polystyrene and Their Properties
III. The Preparation of Spherical Styrene-DVB Copolymers
IV. Chemical Reactions of Styrene-Divinylbenzene Copolymers
- No. of pages:
- © Academic Press 1971
- 1st January 1971
- Academic Press
- eBook ISBN:
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