Biochemical and Structural Dynamics of the Cell Nucleus

Biochemical and Structural Dynamics of the Cell Nucleus

1st Edition - December 28, 1990

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  • Editor: Eugenia Wang
  • eBook ISBN: 9780323157889

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Description

Biochemical and Structural Dynamics of the Cell Nucleus is a collection of papers dealing with the biology of the cell nucleus. The collection describes the methods used in isolating and defining the chemistry and functional interactions of the nuclear components. Some papers also discuss the diversity of the roles that these components play in regulating cellular phenotypes, differentiation, and proliferation. One paper discusses the possible role for lamin A in muscle differentiations, where due to its presence and the appearance of A-type lamins during the differentiation of a number of cell types, lamin A or any of its isoelectric variants cannot specifically be responsible for the induction of muscle specific gene expression. The work of Loewinger and McKeon (1988) can show evidence of the role for lamin A in the differential expression of muscle-specific genes during the process of myogenesis if the investigator uses an alternative method. Several papers also discuss the dynamics of assembly and disassembly of the nuclear lamina and envelope, DNA- and RNA-binding proteins, as well as the nucleocytoplasmic transport. The collection can prove valuable to biochemists, cellular biologists, microbiologists, and molecular biologists.

Table of Contents


  • Preface

    Section I Architecture and Structural Components of the Cell Nucleus

    The RNA-Containing Core Filaments of the Nuclear Matrix

    A Possible Role for Lamin A in Muscle Differentiation

    Molecular Cloning and Nuclear Localization of Lymphoid Membrane Skeletal Protein 4.1

    Section II Dynamics of Assembly/Disassembly of Nuclear Lamina and Envelope

    Functional Analysis of Nuclear Lamins by Mutagenesis

    Nuclear Envelope Breakdown is Regulated by Calcium and CAM Kinase

    Calmodulin and Calmodulin Function in Liver Cell Nuclei

    Section III Proliferation/Differentiation-Dependent Nuclear Antigens

    Molecular Differentiation of a cDNA for Statin, a Non-Proliferating Cell-Specific Nuclear Protein, from Elongation Factor-1α Gene

    Monoclonal Antibodies Against Nuclear Antigens Associated with Proliferation and Differentiation of Bovine Esophageal Epithelium

    Gene Expression at the G1/S Boundary

    The Induction of c-Fos and c-Myc mRNA and the Expression of PCNA/Cyclin

    Dynamics of the Nucleus During Lymphocyte Activation

    Section IV DNA- and RNA-Binding Proteins

    Role of Topoisomerase I in Signal Transduction

    Factors Involved in the Spliceosome Assembly Pathway in Yeast

    Identification of a Carbohydrate Binding Protein in Heterogeneous Nuclear Ribonucleoprotein Complex (hnRNP)

    Section V Nucleocytoplasmic Transport

    An In Vitro Analysis of Nuclear Transport

    Analysis of Nuclear Envelope ATP-Binding Proteins

    A Dynamic Analysis of the Nuclear Pore Complex—The Intelligent Tunnel

    Index

Product details

  • No. of pages: 282
  • Language: English
  • Copyright: © Academic Press 1990
  • Published: December 28, 1990
  • Imprint: Academic Press
  • eBook ISBN: 9780323157889

About the Editor

Eugenia Wang

Eugenia Wang is Director of The Bloomfield Centre for Research in Aging, Lady Davis Institute for Medical Research in Montreal, Canada. With a Ph.D. from Case Western Reserve University, Dr. Wang holds several current appointments including Associate Director, Division of Geriatric Medicine and Aging, Department of Medicine at McGill University, is a member of the National Advisory Council, National Institute of Aging, National Institutes of Health, and is Past Chairperson of the Biological Science Section of the Canadian Association on Gerontology.

Affiliations and Expertise

The Bloomfield Centre for Research in Aging, Montréal, Québec, Canada

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