Biochemical and Molecular Aspects of Selected Cancers

Biochemical and Molecular Aspects of Selected Cancers

1st Edition - October 28, 1991

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  • Editors: Thomas G. Pretlow, Theresa P. Pretlow
  • eBook ISBN: 9781483282053

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Biochemical and Molecular Aspects of Selected Cancers, Volume I provides an overview of important topics and prototypes in cancer research. The book consists of papers provided by outstanding investigators in diverse disciplines in different areas of cancer research. This volume focuses on topics relevant to cancers in humans. It covers such topics as tumor-suppressor genes and human neoplasia; protein kinase C in neoplastic cells; and extracellular matrix interactions with tumor-progressing cells: tumor versus cell type-specific mechanisms. Structural and functional characteristics of human melanoma; steroid hormones and hormone receptors in neoplastic diseases; and patterns and significance of genetic changes in neuroblastomas are expounded as well. Oncologists, biochemists, cytologists, and other researchers in allied fields will find the book invaluable.

Table of Contents

  • Preface

    1. Tumor-Suppressor Genes and Human Neoplasia

    I. Introduction

    II. Methods for Identifying Tumor-Suppressor Genes

    III. Mechanisms of Tumor-Suppressor Gene Action

    IV. Dominant Effect of Mutant Alleles

    V. Genomic Imprinting

    VI. Interactions of Tumor-Suppressor Genes with Oncogenes

    VII. Significance


    2. Protein Kinase C in Neoplastic Cells

    I. Introduction

    II. Cellular Models: Evidence for a Role of Protein Kinase C in Growth Regulation

    III. Role of Protein Kinase C in Tumors and Tumor Cell Lines of Specific Tissues

    IV. Protein Kinase C and Multidrug Resistance

    V. Future Directions


    3. HER-2/neu Oncogene Amplification and Expression in Human Mammary Carcinoma

    I. Introduction

    II. Molecular Biology of HER-2/neu

    III. Clinical Biology of HER-2/neu

    IV. Summary


    4. Extracellular Matrix Interactions with Tumor-Progressing Cells: Tumor Versus Cell Type-Specific Mechanisms

    I. Introduction

    II. Tumor Cell-Specific Adhesion Mechanisms

    III. Matrix Adhesion During Tumor Progression

    IV. Interference with Tumor Progression at the Cell-Matrix Interface

    V. Molecular Biological Approaches for Evaluating Tumor Progression Events

    VI. Summary and Future Directions


    5. Structural and Functional Characteristics of Human Melanoma

    I. Introduction

    II. Tumor Progression in the Human Melanocyte System

    III. Changes in Growth Regulation During Tumor Progression

    IV. Cell-Surface Structures on Melanoma Cells

    V. Melanogenesis in Melanoma

    VI. Summary


    6. Glutathione Transferases in Normal, Preneoplastic, and Neoplastic Tissues: Forms and Functions

    I. Introduction

    II. Molecular Forms of Glutathione Transferase and Their Expression and Functions in Normal Tissues

    III. Glutathione Transferases Increased in (Pre)Neoplastic Tissues

    IV. Concluding Remarks


    7. Steroid Hormones and Hormone Receptors in Neoplastic Diseases

    I. Introduction

    II. Molecular Mechanisms of Steroid Hormone Action

    III. Regulation of Steroid Hormone Receptor Levels in Cells

    IV. Estrogens and Regulation of Tumor Cell Growth

    V. Oncogenic Potential of Steroid Hormones and Steroid Hormone Receptors

    VI. Mechanisms of Steroid Hormone-Induced Tumor Regression

    VII. Mechanisms of Steroid Hormone Unresponsiveness in Tumor Cells

    VIII. Steroid Hormone Receptors as Prognostic Markers

    IX. Summary and Conclusions


    8. Patterns and Significance of Genetic Changes in Neuroblastomas

    I. Introduction

    II. Genetics of Human Neuroblastoma

    HI. Cytogenetic Abnormalities and Tumor Cell Ploidy in Neuroblastomas

    IV. Deletions, Loss of Heterozygosity (LOH), and Suppressor Genes

    V. Oncogene Amplification and Expression in Neuroblastomas

    VI. Structural Analysis of the MYCN-Amplified Domain in Neuroblastomas

    VII. Genetics of Neuroblastomas Identified by Screening

    VIII. Summary and Conclusions


    9. Colonic and Pancreatic Mucin Glycoproteins Expressed in Neoplasia

    I. Introduction

    II. Mucin Glycoproteins

    III. Alteration of Mucin Glycoproteins in Premalignant and Malignant Colorectal Cells

    IV. Alteration of Mucin Glycoproteins in Pancreatic Cancer

    V. Clinical Application

    VI. Summary and Conclusion


    10. Pyruvate Kinase in Selected Human Tumors

    I. Introduction

    II. Genetic System of Pyruvate Kinase

    III. Kinetics: Phosphorylation

    IV. Antibodies Specific for Type K Pyruvate Kinase. Application in Immunohistochemical Studies

    V. Isozyme Distribution in Neoplasia

    VI. Discussion

    VII. Concluding Remarks


    11. Biochemical Basis for Multidrug Resistance in Cancer

    I. Introduction

    II. Derivation of Multidrug-Resistant Cell Lines

    III. Molecular Biology of Multidrug Transporter

    IV. Drug Interaction Sites on Multidrug Transporter

    V. Mechanism of Action of Drug Transport

    VI. Conclusions


    12. Role of p53 in Neoplasia

    I. Introduction

    II. Historical Perspective

    III. p53-Related Alterations in Human Cancer

    IV. Molecular Properties of the p53 Protein

    V. Conclusion


    13. Chromosomal Markers of Cancer

    I. Introduction

    II. Myeloid and Lymphoid Tumors

    III. Solid Tumors

    IV. Biomarkers of Exposure

    V. New and Emerging Tools for Diagnosis

    VI. Conclusions



Product details

  • No. of pages: 454
  • Language: English
  • Copyright: © Academic Press 1991
  • Published: October 28, 1991
  • Imprint: Academic Press
  • eBook ISBN: 9781483282053

About the Editors

Thomas G. Pretlow

Theresa P. Pretlow

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