Biochemical and Clinical Aspects of Oxygen

1st Edition - January 1, 1979
Editor: Winslow Caughey
Language: English
eBook ISBN:
9 7 8 - 0 - 3 2 3 - 1 4 2 0 9 - 0

Biochemical and Clinical Aspects of Oxygen contains the proceedings of a symposium held on the Pingree Park Campus of Colorado State University on September 24-29, 1978.… Read more

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Biochemical and Clinical Aspects of Oxygen contains the proceedings of a symposium held on the Pingree Park Campus of Colorado State University on September 24-29, 1978. Contributors discuss the biochemical and clinical aspects of oxygen, focusing on reactions and areas relating to heme, flavin, copper and nonheme iron proteins, organ transplants, carbon monoxide formation and detoxification, oxidant drugs and pollutants, oxygen toxicity, enzyme inactivation, lipid peroxidation, membrane destruction, antioxidants, cataractogenesis, mutagen and carcinogen formation, malaria and trypanosome parasites, and inflammation. This volume is organized into 51 chapters and begins with a discussion of bonding and reactions of dioxygen bound to hemeproteins, along with the pathophysiology of hemolysis due to unstable hemoglobins. The focus then turns to the reactivity and function of leghemoglobin, reduction of oxygen and five redox forms of horseradish peroxidase, and acid-base catalysis and hydrogen bonding in reactions mediated by peroxidases. The reader is methodically introduced to the ligands of cytochrome P-450 and their role in the activation of dioxygen, oxygen and catabolite regulation of hemoprotein biosynthesis in yeast, and factors controlling hemoprotein reactivity. A chapter describing the spectroscopic mapping of oxygen supply and demand in the heart concludes the book. This book will be of interest to biochemists, biophysicists, physicians, toxicologists, immunologists, physiologists, parasitologists, radiologists, and environmentalists.

List of Contributors

Preface

Bonding and Reactions of Dioxygen Bound to Hemeproteins

Pathophysiology of Hemolysis Due to Unstable Hemoglobins

Formation of Methemoglobins and Peroxide from the Reaction of Oxyhemoglobins with Reducing Agents

Myoglobin in Isolated Adult Heart Cells

Reactivity and Function of Leghemoglobin

Superoxide as a Participant in the Chemistry of Oxyhemoglobin

Theoretical Studies of the Bonding of O2 to Hemoglobin; Implications for Cooperativity

Polarized Single Crystal Absorption Spectra of the Reaction Products of Sperm Whale Myoglobin with O2, OH-, and H2O2

A Comment on the Electronic Structure of the Fe-O2 Group in Oxyheme

Reduction of Oxygen and Five Redox Forms of Horseradish Peroxidase

Hydrogen Peroxide, Oxygen, Superoxide Anion, Singlet Oxygen, and Peroxidase

The Heme-Environment of Iron and Manganese Horseradish Peroxidase as Studied by Water Proton Relaxation and Oxygen-17 Superhyperfine Interaction

Acid-Base Catalysis and Hydrogen Bonding in Reactions Mediated by Peroxidases

Fatty Acid Oxygenase Kinetics and the Role of Peroxides 3. Hydroperoxides in Inflammation: Cellular and Molecular Recruitment

The Ligands of Cytochrome P-450: Identification and Role in the Activation of Dioxygen

Mechanism of Action of Cytochrome P-450 Studied with Peracids as Oxygen Donors

Oxo- and Peroxo-Transition Metal Species in Chemical and Biochemical Oxidations. Possible Models for the Oxygen Activation and Transfer Catalyzed by Cytochrome P-450

Studies on Oxygen Reduction by Heart Cytochrome c Oxidase

Is Compound C Another Carbon Monoxide Complex of Cytochrome c Oxidase?

Electron Transfer From Cytochrome c to Dioxygen by Cytochrome c Oxidase

Role of Oxygen and Cytochrome c Oxidase in the Detoxification of CO by Oxidation to CO2

Some Physical Properties of Hydroxyindole Oxidase

Reduction of Cytochrome c

Some Recent Studies on the Abnormal Pathways of Heme Degradation Not Involving Production of Carbon Monoxide

Characterization of the Steady State Oxygen Kinetics of Terminal Oxidases in Trypanosoma rhodesiense

Oxygen and Catabolite Regulation of Hemoprotein Biosynthesis in Yeast

Reduction of Oxygen by Cytochrome Oxidase Models

Factors Controlling Hemoprotein Reactivity as Studied with Synthetic Model Compounds

On the Mechanism of Flavin-Catalysed Hydroxylation Reactions

On the Chemistry of Flavin Dependent Oxygen Activation

Singlet Molecular Oxygen Chemistry and Implications for Flavin-Cofactor Hydroxylations

Oxygen and Hydrogen Peroxide Promoted Interconversion of Iron(II) and Iron(III) in Hemerythrin

Isolation and Properties of Protocatechuate Dioxygenase from Pseudomonas putida

The Quaternary Structure of Mushroom Tyrosinase and the Subunit Composition of Four Active Species of the Enzyme

Detection of Singlet Oxygen in Complex Systems: A Critique

Generation and Subsequent Quenching of Singlet Oxygen in the Reaction of Potassium Superoxide with Iodine

The Role of Superoxide in the Induction of Superoxide Dismutase and Oxygen Toxicity

The Chemical Reactivity of Superoxide Anion in Aprotic versus Protic Media: A Review

Measure of and Protection from in Vivo Lipid Peroxidation

Lipid Peroxidation in Model and Natural Membranes

Generation of Oxygen Metabolites by Phagocytic Cells: Studies with a Subcellular Fraction of Human Neutrophils

The Effect of Temperature on Chemiluminescence by Polymorphonuclear Leukocytes in Vitro

Organismal, Tissue, and Enzymatic Level Metabolic Responses to an Oxygen-Rich Environment

Specific Enzymatic Sites and Cellular Mechanisms of Oxygen Toxicity

Effect of Oxygen and Related Radicals on Rat Pulmonary Cells

Mechanism of Cataractogenesis Induced by 3-Amino-1H-1,2,4-Triazole I: Morphology and Histopathology of Cataract and the Role of Catalase in the Regulation of H2O2 in the Eye

Mechanism of Cataractogenesis Induced by 3-Amino-1H-1,2,4-Triazole II: Superoxide Dismutase of the Eye and Its Role in Protecting the Ocular Lens from Oxidative Damage by Endogenous O2∙- , H2O2 and/or OH∙

The Role of Oxygen in the Radiation Biology of Tumors

Malaria Infection and Host Cell Oxidant Damage

The Enhanced Survival of Mouse Thyroid Allografts After Treatment with Hyperbaric Oxygen

Spectroscopic Mapping of Oxygen Supply-Demand in Heart

Index