Biochemical Actions of Hormones V13

Biochemical Actions of Hormones V13

1st Edition - January 28, 1986

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  • Editor: Gerald Litwack
  • eBook ISBN: 9780323150330

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Biochemical Actions of Hormones, Volume XIII is a 13-chapter text that explores the biochemical aspects of polypeptide, steroid, and insect hormones. The opening chapters examine the control of glucose transport by insulin, the participation of nuclear poly(adenosine diphosphate-ribosyl)ation in hormonal mechanisms, and the concept of ovulation control. These topics are followed by discussions on the immunohistochemistry of human chorionic gonadotropin; the adrenocorticotropic hormone (ACTH) action on adrenal cholesterol metabolism and its interaction with adrenal receptors; the structure-activity relationships of neurohypophyseal hormones; and the interactions between different functional sites in the epidermal growth factor receptor. A chapter focuses on the juvenile hormone-binding proteins. The remaining chapters consider the actions of steroid hormones. These chapters specifically describe the androgen receptor, the interaction of the glucocorticoid receptors with specific DNA sequences, and glucocorticoid actions on fibroblasts. A discussion on the potential role of RNA in the glucocorticoid receptor mechanism is also included in these chapters. This book will be of great benefit to endocrinologists, biochemists, biologists, and researchers who are interested in hormonal action and regulation.

Table of Contents

  • Contributors


    1. Mechanism of Insulin's Stimulatory Action on Glucose Transport in the Rat Adipose Cell

    I. Glucose Transport Activity in the Intact Cell

    II. Steady-State Subcellular Distribution of Glucose Transporters

    III. Characteristics of the Response to Insulin

    IV. The Translocation Hypothesis

    V. Counterregulation by Adenylate Cyclase Stimulators and Inhibitors

    VI. Chronic Regulation of the Response to Insulin

    VII. Summary


    2. Possible Participation of Nuclear Poly(ADP-ribosyl)ation in Hormonal Mechanisms

    I. Introduction

    II. Experimental

    III. Discussion

    IV. Summary


    3. Hormonal Control of Ovulation

    I. Introduction

    II. Oocyte Maturation

    III. Maturation of the Cumulus Oophorus

    IV. Luteinization

    V. Follicular Rupture

    VI. Concluding Remarks


    4. Immunochemistry of Human Chorionic Gonadotropin

    I. Introduction

    II. Chemistry of Human Chorionic Gonadotropin

    III. Immunochemistry of the hCGß Subunit Carboxy-Terminal Peptide Region

    IV. Regions of the hCG Surface Which Elicit Specific Immune Responses

    V. Application of Improved Methods for hCG Detection in Clinical Specimens

    VI. Use of Monoclonal Antibodies to Examine the Relationship between hCG Structure and Biological Activity


    5. The Mechanism of Action of Adrenocorticotropic Hormone on Cholesterol Metabolism in the Adrenal Cortex

    I. Introduction

    II. Overall Pathway of Glucocorticoid Synthesis from Adrenal Cholesterol

    III. Adrenocortical Cholesterol

    IV. Pathways of Adrenal Cholesterol Metabolism

    V. Summary

    References 159

    6. Interaction of Corticotropin with Adrenocortical Cell Receptors

    I. Introduction

    II. Early Studies of ACTH Receptors

    III. Difficulties in Detecting ACTH Receptors

    IV. Synthesis of a Radioligand with Full Biological Potency

    V. Characterization of ACTH Receptors in Rat Adrenocortical Cells

    VI. ACTH Receptors in Human Adrenocortical Cells


    7. Structure-Activity of the Neurohypophyseal Hormones and Analogs and Implications for Hormone-Receptor Interactions

    I. Introduction

    II. Structures of the Neurohypophyseal Hormones

    III. Oxytocin Structure-Function Relationships

    IV. Vasopressin Structure-Function Relationships

    V. Concluding Remarks


    8. Interactions between Different Functional Sites in the EGF Receptor

    I. Introduction

    II. Mapping of the Functional Sites in EGF Receptor by Limited Proteolysis

    III. 42,000 Molecular Weight Fragment of EGF Receptor Has Protein Kinase Activity

    IV. Regulation of Kinase Catalytic Function by Receptor—Receptor Interaction and EGF-Induced Modulation of This Interaction

    V. Overall Picture and Relationship to the In Vivo Situation


    9. Juvenile Hormone-Binding Proteins

    I. Introduction

    II. Background

    III. Hemolymph JH-Binding Proteins

    IV. Intracellular JH-Binding Proteins


    10. Androgen Receptor Protein: Purification and Molecular Properties

    I. Introduction

    II. Steroid Binding Properties

    III. Purification of Androgen Receptor

    IV. Affinity Labeling of the Receptor

    V. Molecular Forms of the Receptor

    VI. Conclusions


    11. Interaction of the Glucocorticoid Receptor with Specific DNA Sequences

    I. Introduction

    II. Identification of Regions Necessary in Mouse Mammary Tumor Virus DNA for Hormone-Sensitive Transcription In Vivo

    III. Specific Sites on MMTV DNA Are Recognized by the Activated Glucocorticoid—Receptor Complex In Vitro

    IV. Correlation of Glucocorticoid Receptor-Binding Sites in the MMTV Proviral DNA with Hormone-Inducible Transcription

    V. DNA Footprinting Analysis of the Glucocorticoid Receptor-Binding Sites on the MMTV LTR

    VI. Interaction of Mutant Receptors and Antiglucocorticoid-Receptor Complexes with MMTV LTR Sequences

    VII. Hormone Inducibility Conferred by Sequences of Other Glucocorticoid-Inducible Genes

    VIII. The Glucocorticoid and the Progesterone Receptors Bind to the Same Sites in Two Hormonally Regulated Promoters

    IX. The Glucocorticoid-Responsive Element is a Transcriptional Enhancer

    X. Secondary DNA Structures in the Glucocorticoid-Dependent Enhancer Element

    XI. Conclusions


    12. Glucocorticoid Actions on Fibroblasts in Tissue Culture

    I. Introduction

    II. Fibroblast Models for the Study of the Mechanisms of Glucocorticoid Hormone Action

    III. Glucocorticoid Effects on Cellular Proliferation

    IV. Effects of Glucocorticoids on Glucose and Amino Acid Transport

    V. Protein Synthetic Effects of Glucocorticoids in Fibroblasts

    VI. Conclusion


    13. Association of RNA with the Glucocorticoid Receptor and Possible Role in Activation

    I. Introduction

    II. Association of RNA with Activated GR Complexes

    III. Association of RNA with Unactivated GR Complexes

    IV. Possible Role of an RNA in Receptor Activation

    V. Physiological Significance

    VI. Summary



Product details

  • No. of pages: 438
  • Language: English
  • Copyright: © Academic Press 1986
  • Published: January 28, 1986
  • Imprint: Academic Press
  • eBook ISBN: 9780323150330

About the Editor

Gerald Litwack

Dr. Litwack is an accomplished and prolific author and editor at Elsevier. Spanning over 25 years, he has been the editor of over 55 volumes of Vitamins and Hormones, co-author of Hormones, editor of 14 volumes of Biochemical Actions of Hormones, co-editor of Actions of Hormones on Molecular Processes, author of Human Biochemistry and Disease, and just wrapping up Human Biochemistry. He also authored Experimental Biochemistry [Wiley] and edited Receptor Purification, 2 volumes [Humana]. He is an author on over 300 journal articles and has been on the editorial boards of numerous journals, including Endocrinology, Oncology Research, Oncology Reports, Journal of Molecular Biochemistry, Chemtracts, Cancer Research, Apoptosis, and Critical Reviews in Eukaryotic Gene Expression.

Affiliations and Expertise

Emeritus Professor and Chair of Basic Sciences, Geisinger Commonwealth School of Medicine, Scranton, PA, USA

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