Biochemical Actions of Hormones V1 - 1st Edition - ISBN: 9780124528017, 9780323145336

Biochemical Actions of Hormones V1

1st Edition

Editors: Gerald Litwack
eBook ISBN: 9780323145336
Imprint: Academic Press
Published Date: 28th January 1970
Page Count: 580
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Biochemical Actions of Hormones, Volume I explores the significant developments toward understanding the primary effects of hormones in cellular receptors at the molecular level. This book is composed of 12 chapters that survey the molecular and biochemical approaches bearing on the problem of hormone mechanism. The opening chapters discuss the thyroid hormonal responses during metamorphic process in Amphibia; the primary role of hormones in biochemical differentiation; the influence of hormones on protein synthesis and the importance of protein synthesis mechanism; and the biochemical rhythms within the pineal gland and the rhythm in hepatic tyrosine transaminase activity. The subsequent chapters examine the effects of a number of hormones on transport systems in the cell membranes, the protein interaction with steroids, and the influence of insulin on protein and nucleic acid metabolism. The remaining five chapters deal with the physiology, mechanism of action, and biological effects of various hormones, such as mineralocorticoids, parathyroid hormone, calcitonin, thyrotropin, and plant hormones. This book is an invaluable source for endocrinologists.

Table of Contents

List of Contributors


1. Hormonal Responses in Amphibian Metamorphosis

I. Introduction

II. Interrelationships of Hormones during Anuran Metamorphosis

III. Changes in Blood

IV . The Development of the Nervous System

V. Responses of the Skin

VI. Intestinal Development

VII. Regression of the Pancreas

VIII. Developmental Changes in the Liver

IX. Tail Resorption

X. Changes in Calcium and Bone Metabolism

XI. Miscellaneous Effects

XII. Some General Comments and Conclusions about Anuran Metamorphosis


2. The Developmental Formation of Enzymes in Rat Liver

I. Introduction

II. Critical Stages of Enzymic Differentiation in the Liver

III. The Late Fetal Stage

IV. Neonatal Period

V. Late Suckling Period

VI. The Problems of the Mechanisms of Developmental Enzyme Formation

VII. Biochemical Differentiation of Liver in Species Other Than Rat

VIII. General Observations

IX. Brief Summary


3. Regulation of Protein Synthesis by Growth and Developmental Hormones

I. Introduction

II. Regulatory Mechanisms of Protein Synthesis in Animal Cells

III. Hormones and Protein Synthesis

IV. The Role of Cell Structure

V. Phenomenology and Mechanism of Action


4. The Regulation of Some Biochemical Circadian Rhythms

I. Introduction

II. Circadian Rhythms in the Pineal Gland

III. Circadian Rhythm of Hepatic Tyrosine Transaminase Activity

IV. Conclusions: Possible Driving Oscillations of Biochemical Rhythms


5. Hormones and Transport across Cell Membranes

I. Introduction

II. Some Hormonal Effects on Transports

III. Evidence that Hormones Affect Only One of the Transport Systems for Neutral Amino Acids

IV. Concluding Remarks


6. Binding of Hormones to Serum Proteins

I. General Characteristics of Hormone-Protein Complexes

II. Thyroid Hormone-Binding Proteins

III. Steroid Hormone-Binding Proteins

IV. Synopsis


7. Insulin and Protein Synthesis

I. Introduction

II. General Effects of Insulin on Nitrogen Metabolism

III. Protein Synthesis in Muscle

IV. Accumulation of Amino Acids by Muscle

V. Effect of Insulin on Labeling of Aminoacyl-tRNA

VI. Insulin and RNA Metabolism in Muscle

VII. Protein Synthesis in Subcellular Systems

VIII. Summary and Conclusions


8. Mineralocorticoids

I. Historical Background

II. Comparative Physiology

III. The Induction Hypothesis

IV. Role of Aldosterone-Induced Protein (AIP) in Mineralocorticoid Action

V. The Oxidative Phosphorylation Hypothesis

VI. Model of the Mechanism of Mineralocorticoid Action

VII. Future Directions


9. Parathyroid Hormone and Calcitonin

I. Introduction

II. Calcium Exchange in Cells and Subcellular Compartments

III. Bone Cells and Their Function

IV. Parathyroid Hormone, 3',5'-AMP, and Intracellular Calcium

V. Mode of Action of Calcitonin

VI. PTH, Vitamin D, and Intracellular Ca++

VII. Summary and Conclusions


10. Mechanism of Action of Thyrotropin

I. Introduction

II. The Specific Interaction of Thyrotropin with Thyroid Cellular Components

III. Cyclic 3',5'-AMP as the Intracellular Mediator of Thyrotropin Action on the Thyroid


11. The Thymus as an Endocrine Gland: Hormones and Their Actions

I. Introduction

II. Modern Concepts of the Thymus as an Endocrine Gland

III. Chemistry and Actions of Thymic Fractions

IV. Biological Effects of Thymic Extracts

V. Summary


12. Plant Hormones

I. Introduction

II. Auxins

III. Gibberellins

IV. Cytokinins

V. Abscisic Acid

VI. Ethylene


Author Index

Subject Index


No. of pages:
© Academic Press 1970
Academic Press
eBook ISBN:

About the Editor

Gerald Litwack

Dr. Litwack is an accomplished and prolific author and editor at Elsevier. Spanning over 25 years, he has been the editor of over 55 volumes of Vitamins and Hormones, co-author of Hormones, editor of 14 volumes of Biochemical Actions of Hormones, co-editor of Actions of Hormones on Molecular Processes, author of Human Biochemistry and Disease, and just wrapping up Human Biochemistry. He also authored Experimental Biochemistry [Wiley] and edited Receptor Purification, 2 volumes [Humana]. He is an author on over 300 journal articles and has been on the editorial boards of numerous journals, including Endocrinology, Oncology Research, Oncology Reports, Journal of Molecular Biochemistry, Chemtracts, Cancer Research, Apoptosis, and Critical Reviews in Eukaryotic Gene Expression.

Affiliations and Expertise

, Emeritus Professor and Chair of Basic Sciences, Geisinger Commonwealth School of Medicine, Scranton, PA

Ratings and Reviews