Behavioral and Neural Genetics of Zebrafish
1st Edition
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Description
The past decade has seen a rapid accumulation of knowledge on the behavioral characteristics of zebrafish, and their use in increased investigation into the neurobiological basis of behavior. This simple vertebrate represents an ideal compromise between system complexity and practical simplicity, with its mammalian sequence homology, fecundity, transparent embryology, and conveniently small size. Behavioral and Neural Genetics of Zebrafish assembles the state-of-the-art methodologies and the most current concepts pertinent to their neurobehavioral genetics. Discussing its natural behavior, motor function, and learning and memory, it focuses on the fry and adult zebrafish and features a comprehensive account of modern genetic and neural methods adapted to or specifically developed for Danio rerio. Numerous examples of how these behavioral methods may be utilized for disease models using the zebrafish will be presented, as well as a section on bioinformatics and "big-data" related questions. Focusing on this excellent translational tool, this book examines a species with which investigators may model and analyze even such complex human diseases as those associated with brain dysfunction.
Key Features
- Provides the most comprehensive snapshot of the fast-evolving zebrafish neurobehavior genetics field
- Describes behavioral, genetic, and neural methods and concepts for use in adult and larval zebrafish
- Features examples of zebrafish models of human central nervous system disorders
- Discusses bioinformatics questions pertinent to zebrafish neurobehavioral genetics
Readership
Neuroscientists, behavioral neuroscientists, neurobiologists, experimental biologists, behavioral geneticists, psychologists, graduate students, and post-doctoral fellows
Table of Contents
Section I. Introduction to Zebrafish: Natural Habitat, Ethology, and Appropriate Maintenance Conditions
1. The biotic and abiotic environment of zebrafish
2. Maintenance and breeding of zebrafish, with some ethological and ecological considerations in mind
Section II. The Behavior of the Fry
3. The larval visual system and behavioral responses to visual stimuli
4. Visual escape in larval zebrafish: Stimuli, circuits, and behavior
5. Functional review of hearing in zebrafish
6. The development of social behavior
7. Classical and operant conditioning in larval zebrafish
Section III. The Behavior of the Adult
8. Motor patterns and swim path characteristics: the ethogram of zebrafish
9. Behavioral criteria and techniques to define sleep in zebrafish
10. Fear responses and antipredatory behavior of zebrafish: A translational perspective
11. Social behavior and its psychopharmacological and genetic analysis in zebrafish
12. Associative and non-associative learning in adult zebrafish
13. Relational learning in zebrafish: A model of declarative memory in humans?
Section IV. Genetic Methods for Zebrafish
14. Molecular genetic approaches to dissect complex behaviors in zebrafish
15. Behavioural research in zebrafish (Danio rerio): strain as source of variation
16. Designer mutants for behavioral genetics
17. Optogenetics
18. The CRISPR/Cas system in zebrafish
19. PhOTO Zebrafish and primed conversion: Advancing the mechanistic view of development and disease
Section V. Disease Models and Behavior Genetic Applications
20. Acute and chronic alcohol effects in zebrafish
21. Behavioural genetics of embryonic ethanol exposure in zebrafish: A model for FASD
22. Life, death, and regeneration of zebrafish dopaminergic neurons
23. Parkinson's Disease
24. Seizures and epilepsy
25. Aging, circadian clock and neurogenesis: the zebrafish approach
26. Autism models
27. Studying aggression in zebrafish
28. Methylmercury induces transgenerationally transmissible epigenetic changes influencing zebrafish behavior
Section VI. Big Data and Bioinformatics
29. The design of behavioral screening in zebrafish
30. Software tools for behavioral phenotyping of zebrafish across the life span
31. The Zebrafish Genome Sequencing Project: Bioinformatics resources
32. Registered, standardized and interactive: a review of online resources for zebrafish neuroanatomy
Details
- No. of pages:
- 738
- Language:
- English
- Copyright:
- © Academic Press 2020
- Published:
- 10th April 2020
- Imprint:
- Academic Press
- Hardcover ISBN:
- 9780128175286
About the Editor
Robert Gerlai
Dr. Gerlai received his Ph.D. from the Hungarian Academy of Sciences with the highest distinction in 1989. He has held numerous academic positions in Europe and North America (Eötvös University of Budapest, Mount Sinai Hospital Research Institute of Toronto, Indiana University Purdue University Indianapolis, University of Hawaii Honolulu), and he also held leadership positions in the US biotechnology and biopharmaceutical research industry working as a senior research scientist and Vice President (Genentech Inc. South San Francisco, Eli Lilly & Co. Indianapolis, Saegis Pharma Half Moon Bay) before joining the University of Toronto in 2004, where he is currently full professor at the Department of Psychology. Dr. Gerlai has published over 200 papers in peer reviewed scientific journals and books with a cumulative citation number over 12000 and an H index of 55. He is member of editorial boards of PLOS ONE, Learning and Behavior, Genes Brain and Behaviour, Neurotoxicology and Teratology. He is Associate Editor of Frontiers in Genetics of Complex Traits, Review Editor for Frontiers in Neuroscience and Section Editor for BioMedCentral Neuroscience. He has edited several special issues of scientific journals and served as co-editor of handbooks on molecular genetic approaches in behavioural neuroscience. He is founding member of the International Behavioral and Neural Genetics Society, IBANGS. He was the president of the International Behavioral Neuroscience Society (IBNS) in 2007 and 2008, and he has been elected Fellow of this Society since 2005. He received the Distinguished Scientist Award from IBANGS in 2013 and the John Wiley Distinguished Speaker Award from the International Society of Developmental Psychobiology in 2014. In 2015, he was awarded the University of Toronto Mississauga Excellence in Research Award. Dr. Gerlai’s research focusses on the biological and genetic mechanisms of behaviour. For the past fourteen years his research at University of Toronto has been using zebrafish employing behavioural phenotyping, psychopharmacological and genetic methods to study mechanisms of alcohol abuse, fetal alcohol spectrum disorders, and of learning and memory. His laboratory has been funded by NIH, NSERC and Brain Canada.
Affiliations and Expertise
Department of Psychology, University of Toronto Mississauga, Mississauga, Ontario, Canada