Bacterial Vaccines

Contributors

Preface


1 Diphtheria

I. Introduction

II. History of Diphtheria

III. Biology of Diphtheria

IV. Diphtheria Toxin and Toxoid

V. Immunization against Diphtheria

VI. Effect of Mass Immunization on the Epidemiology of Diphtheria

VII. Conclusions and Future Prospects

References


2 Tetanus

I. Introduction

II. The Causative Agent

III. Pathogenesis

IV. Clinical Features

V. Epidemiology

VI. Presently Available Vaccines

VII. Presentation of Tetanus Vaccines

VIII. Laboratory Control of Vaccines and WHO Requirements

IX. Clinical Assessment of Vaccines

X. Results of Field Trials Using Conventional and Overdosed Vaccines in One, Two, or Three Injections

XI. Drawbacks

XII. Prospects for New Vaccines

References


3 Pertussis

I. Introduction

II. Pertussis (Whooping Cough)

III. Chemotherapy, Chemoprophylaxis, Pertussis Immune Globulin

IV. Pertussis Vaccine

V. Prospects for New Pertussis Vaccines

VI. Immunization Schedules

VII. Can Pertussis Be Eradicated?

References


4 Cholera

I. Prologue

II. Introduction

III. Conventional Killed Vibrio cholerae Vaccines Administered Parenterally

IV. Killed Vaccines Administered Perorally

V. The Pathogenesis of Cholera

VI. The Cholera Enterotoxin (Choleragen or CT), Its Derivatives, and Its Relatives

VII. Combined Nonliving Vaccines

VIII. Live Vaccines: "Ferran and Haffkine Revisited"

References


5 Typhoid Fever

I. Introduction

II. Presently Available Vaccines

III. Development of New Typhoid Vaccines

IV. Live Oral Vaccines

References


6 Shigellosis

I. Introduction

II. Characteristics of Shigellae

III. Studies of Potential Vaccines in Animals

IV. Studies of Potential Vaccines in Humans

V. Prospects for New Vaccines

References


7 Escherichia coli Infections

I. Introduction

II. Vaccines

References


8 Meningococcal Meningitis

I. Introduction

II. Presently Available Vaccines

III. Prospects for New Vaccines

References


9 Pneumococcal Infections

I. Pneumococcal Infections

II. Immunity to Pneumococcal Infection

III. Pneumococcal Vaccines

References


10 Haemophilus influenzae Type b Infections

I. Introduction

II. Historical

III. Description of the Organism

IV. Clinical Diseases

V. Vaccine Development

VI. Considerations for Inclusion of Haemophilus influenzae Type b Vaccines for Routine Immunization

VII. Other Vaccine Candidates

References


11 Pseudomonas aeruginosa Infections

I. Introduction

II. Epidemiology and Clinical Significance

III. Pathogenesis of Pseudomonas aeruginosa Infections

IV. Currently Developed Vaccines: Clinical Status

V. Human Immunity to Pseudomonas aeruginosa

VI. Future Prospects: Candidate Vaccines and New Therapeutic

Regimens

References


12 Gonorrhea

I. Introduction

II. Presently Available Vaccines

III. Prospects for New Vaccines

References


13 Tuberculosis

I. Introduction

II. Presently Available Vaccines

III. Prospects for New Vaccines

References


14 Leprosy

I. Introduction

II. Causative Agent

III. Clinical Manifestation

IV. Pathogenesis of Lepromatous Leprosy

V. Epidemiology

VI. Treatment of Leprosy

VII. Vaccines against Leprosy

References

Index