The second edition of Avian Immunology provides an up-to-date overview of the current knowledge of avian immunology. From the ontogeny of the avian immune system to practical application in vaccinology, the book encompasses all aspects of innate and adaptive immunity in chickens. In addition, chapters are devoted to the immunology of other commercially important species such as turkeys and ducks, and to ecoimmunology summarizing the knowledge of immune responses in free-living birds often in relation to reproductive success.

The book contains a detailed description of the avian innate immune system, encompassing the mucosal, enteric, respiratory and reproductive systems. The diseases and disorders it covers include immunodepressive diseases and immune evasion, autoimmune diseases, and tumors of the immune system. Practical aspects of vaccination are examined as well. Extensive appendices summarize resources for scientists including cell lines, inbred chicken lines, cytokines, chemokines, and monoclonal antibodies.

The world-wide importance of poultry protein for the human diet, as well  as the threat of avian influenza pandemics like H5N1 and heavy reliance on vaccination to protect commercial flocks makes this book a vital resource. This book provides crucial information not only for poultry health professionals and avian biologists, but also for comparative and veterinary immunologists, graduate students and veterinary students with an interest in avian immunology.

Key Features

  • With contributions from 33 of the foremost international experts in the field, this book provides the most up-to-date review of avian immunology so far
  • Contains a detailed description of the avian innate immune system reviewing constitutive barriers, chemical and cellular responses; it includes a comprehensive review of avian Toll-like receptors
  • Contains a wide-ranging review of the "ecoimmunology" of free-living avian species, as applied to studies of population dynamics, and reviews methods and resources available for carrying out such research



Immunologists, cell biologists, pathologists, poultry scientists, vaccinologists and veterinarians. Also zoologists, ecologists, ornithologists and evolutionary biologists interested in using immunological parameters as selection traits for studies on survival and evolution

Table of Contents




List of Contributors

Chapter 1. The Importance of the Avian Immune System and its Unique Features

1.1 Introduction

1.2 The Contribution of Avian Lymphocytes

1.3 The Contribution of the Bursa of Fabricius

1.4 The Contribution of the Chicken MHC

1.5 The Contributions to Vaccinology

1.6 Conclusions


Chapter 2. Structure of the Avian Lymphoid System

2.1 Introduction

2.2 The Thymus

2.3 The Bursa of Fabricius

2.4 Germinal Center of the Peripheral Lymphoid Organs

2.5 The Spleen

2.6 Gut-Associated Lymphoid Tissue

2.7 Harderian and Conjuctiva-Associated Lymphoid Tissue

2.8 Mural Lymph Node

2.9 Ectopic Lymphatic Tissue and Pineal Gland

2.10 Bone Marrow

2.11 Blood


Chapter 3. Development of the Avian Immune System

3.1 Introduction

3.2 Origins and Migration Routes of Hematopoietic Cells Using Quail–Chick Complementary Chimeras

3.3 Aortic Clusters as the Intra-Embryonic Source of Definitive Hematopoiesis

3.4 Formation of the Aorta: A Dorsal Angioblastic Lineage and a Ventral Hemangioblastic Lineage

3.5 The Avian Thymus and T Cell Development

3.6 The Bursa of Fabricius, B-Cell Ontogeny and Immunoglobulins

3.7 Lymphocyte-Differentiating Hormones

3.8 Development of the Immune Responses

3.9 Conclusions



Chapter 4. B Cells, the Bursa of Fabricius and the Generation of Antibody Repertoires

4.1 Introduction

4.2 The Generation of Avian Antibody Repertoires

4.3 The Development of Avian B Cells


Chapter 5. Avian T Cells: Antigen Recognition and Lineages

5.1 Introduction

5.2 TCR Structure and Lineages

5.3 CD3 Signaling Complex



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© 2014
Academic Press
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"This book provides foundational and more advanced knowledge on avian immunology… Appendices provide resources for researchers including genetic stocks and monoclonal antibodies and cytokines. This book is a very useful tool for anyone interested in conducting research on the topic or as an advanced introduction to avian immunology.", January-February 2014
"This book is an introduction to the field, beginning with an overview of avian immune system, its unique features and its importance to business and research. Further chapters focus on specific details of avian immune system…Extensive lists of genetic stocks for immunological research and further study resources make this book both a foundational reference and a stepping stone towards more advanced research subjects.", January 2014
“This book would serve as reference that all can resort to for old and new information. This field lacks such a resource and I personally have used the first version extensively whether as refresher or to acquire new knowledge. Much of the classical discoveries in this area are not readily available to the public and this book will afford access to such information. The appendices are especially helpful as many scientists are not aware of the resources available.”--
Dr. Rami A. Dalloul, Associate Professor, Dept. of Animal & Poultry Sciences, Virginia Tech, USA