Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection, and Aging

1st Edition

Volume 3 - Role in Specific Diseases

Editors: M. Hayat
Hardcover ISBN: 9780124055292
eBook ISBN: 9780124055346
Imprint: Academic Press
Published Date: 31st January 2014
Page Count: 432
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Understanding the importance and necessity of the role of autophagy in health and disease is vital for the studies of cancer, aging, neurodegeneration, immunology, and infectious diseases. Comprehensive and up-to-date, this book offers a valuable guide to these cellular processes whilst encouraging researchers to explore their potentially important connections.

Volume 3 explores the role of autophagy in specific diseases and developments, including: Crohn’s Disease, Gaucher Disease, Huntington’s Disease, HCV infection, osteoarthritis, and liver injury. A full section is devoted to in-depth exploration of autophagy in tumor development and cancer. Finally, the work explores the relationship between autophagy and apoptosis, with attention to the ways in which autophagy regulates apoptosis, and the ways in which autophagy has been explored in Lepidoptera, elucidating the use of larval midgut as a model for such exploration.  From these well-developed foundations, researchers, translational scientists, and practitioners may work to better implement more effective therapies against some of the most devastating human diseases.


Volumes in the Series

Volume 1: Molecular Mechanisms. Elucidates autophagy’s association with numerous biological processes, including cellular development and differentiation, cancer, immunity, infectious diseases, inflammation, maintenance of homeostasis, response to cellular stress, and degenerative diseases such as Alzheimer’s, Parkinson's, Huntington's, amyotrophic lateral sclerosis, and prion diseases.
Volume 2: Role in General Diseases. Describes the various aspects of the complex process of autophagy in a myriad of devastating human diseases, expanding from a discussion of essential autophagic functions into the role of autophagy in proteins, pathogens, immunity, and general diseases. 
Volume 3: Role in Specific Dis

Key Features

  • Brings together oncologists, neurosurgeons, physicians, research scientists, and pathologists in the field of autophagy to discuss cutting-edge developments in this rapidly-advancing field
  • Builds upon recent advances in genome-scale approaches and computational tools to discuss the advances in regulation of autophagy at the systems level
  • Organized for readers into easy-to-access sections: molecular mechanisms; role of autophagy in disease; role of autophagy in cancer; and autophagy and apoptosis
  • Explores exciting new developments, including the measurement of autophagic flux; the molecular role of the Atg12-Atg5-Atg16 complex; and the molecular bases of autophagosome formation in yeast

Table of Contents




Abbreviations and Glossary

Autophagy: Volume 1–Contributions

Autophagy: Volume 2–Contributions

List of Contributions Projected in Volume 4

Chapter 1. Introduction to Autophagy: Cancer, Other Pathologies, Inflammation, Immunity, Infection and Aging, Volumes 1–4


Specific Functions of Autophagy (A Summary)

Autophagy in Normal Mammalian Cells

Major Types of Autophagies

Selective Autophagies

Autophagosome Formation

Autophagic Lysosome Reformation

Autophagic Proteins

Monitoring Autophagy

Reactive Oxygen Species (ROS)

Mammalian Target of Rapamycin

Role of Autophagy in Tumorigenesis and Cancer

Role of Autophagy in Immunity

Role of Autophagy in Viral Defense and Replication

Role of Autophagy in Intracellular Bacterial Infection

Role of Autophagy in Heart Disease

Role of Autophagy in Neurodegenerative Diseases

Cross-Talk between Autophagy and Apoptosis

Autophagy and Ubiquitination

Autophagy and Necroptosis



Mitochondrial Fusion and Fission


Part I: Molecular Mechanisms

Chapter 2. Autophagic Flux, Fusion Dynamics, and Cell Death


The Current Conception of Autophagic Flux and its Measurement

Putting a Number to Autophagic Flux

What is not Autophagic Flux: Pitfalls and Cautions

Flux, Fusion, and Trafficking Determine Autophagic Function

Fusion Affects Autophagic Flux

Trafficking Affects Autophagic Flux

Physics Modeling of Autophagy

Tuning Autophagic Flux: Driving Cellular Fate

Future Outlook



Chapter 3. Architecture of the Atg12–Atg5–Atg16 Complex and its Molecular Role in Autophagy



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© Academic Press 2014
Academic Press
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About the Editor

M. Hayat

Dr. Hayat has published extensively in the fields of microscopy, cytology, immunohistochemistry, immunocytochemistry, and antigen retrieval methods. He is Distinguished Professor, Department of Biological Sciences, Kean University, Union, New Jersey, USA.

Affiliations and Expertise

Distinguished Professor, Department of Biological Sciences, Kean University, Union, NJ, USA