
Autophagy and Cardiometabolic Diseases
From Molecular Mechanisms to Translational Medicine
Description
Key Features
- Explains the processes inherent in the protein quality control for pathogenesis and complications of cardiometabolic diseases
- Provides knowledge from internationally recognized contributors in the field
- Incorporates a translational approach, covering the basic cellular biology of autophagy and presenting the role of autophagy regulation for both pathogenesis and complication in cardiometabolic diseases
- Contains access to a companion website with additional illustrations
Readership
Researchers from both academia and industry working in the field of cardiovascular disease and biomedical sciences, medical practitioners, pharmaceutical industry workers, and health professional students
Table of Contents
Section I. Cell biology of cardiometabolic syndrome and autophagy
1. Overview of autophagy and cardiometabolic syndrome
Annayya R. Aroor, Guanghong Jia and James R. Sowers
2. Overview of autophagy and its molecular regulation
Xi Ma, Linsen Li, Ting He, Michael A. Brown and Qing Zhong
3. Interplay among oxidative stress, redox signaling, ER stress, autophagy, and protein ubiquitylation in cardiometabolic disorders
Taixing Cui and Xuejun Wang
4. Mechanism and regulation of selective mitophagy in cardiometabolic disease
Zhi Yang, Jianjun Lv, Jun Ren and Dongdong Sun
5. Experimental models and measurement of autophagy
Wei Zhu, Yong Sun, Yao-liang Tang, Chen Wang, Chang-Chen Xiao, Jing-Hai Chen, Hong Yu, Xin-Yang Hu and Jian’an Wang
6. Role of autophagy in cardiac physiology and pathophysiology
Valerie P. Tan and Shigeki MiyamotoSection II. Autophagy and pathogenesis of cardiometabolic disease
7. Autophagy and diabetes mellitus
Yingmei Zhang
8. Autophagy and hypertension
Feng Cao and Sai Ma
9. Myocardial insulin signaling and autophagy
Jordan Bartlett, Trivedi Purvi, Brian Rodrigues and Thomas Pulinilkunnil
10. Autophagy as a therapeutic target for cardiovascular complications in obesity - concepts, controversies, and challenges
Jun Ren and Yingmei Zhang
11. Autophagy and lipid metabolism in cardiometabolic diseases
Mingjie Yang, Yingmei Zhang and Jun Ren
12. Autophagy and stroke
Pei Wang and Chao-Yu Miao
13. Polycystic ovary syndrome and cardiometabolic disease
Shuyi Wang, Amy M. Navratil and Jun Ren
14. The role of autophagy in vascular biology and atherosclerosis
Ida Perrotta
15. Autophagy and proteostasis in cardiac aging
Dai Dao-Fu and Peter S. Rabinovitch
16. Novel pathways of autophagy for the treatment of nervous system disorders
Kenneth MaieseSection III. Autophagy and complications of cardiometabolic disease
17. Autophagy and liver disease
Sergi Guixé-Muntet and Jordi Gracia-Sancho
18. Chaperone-mediated autophagy and kidney disease
Lu Wang, Ying Han and Jun Ren
19. Autophagy and fetal programming
Alina Maloyan
20. Autophagy, oxidative stress and redox regulation
Jipeng Ma, Lifang Yang, Jun Ren and Jian YangSection IV. Translational approach of autophagy
21. Autophagy-driven cancer drug development
Amine Belaid, Barnabé Roméo, Harilaos Filippakis, Mickael Meyer, Guillemette Crépeaux, Romain K Gherardi, Dominique Lagadic-Gossmann, Martin Von Bergen, Abderrahman Chargui, Eric Gilson, Delphine Benarroch-Popivker, Patrick Brest, Paul Hofman and Baharia Mograbi
22. Autophagy: a new therapeutic target
Asli F. Ceylan
23. Autophagy regulates control of intracellular energy stores
Michael N. Sack
24. Autophagy and epigenetics
Xu-Dong Wang, Thomas G. Gillette and Zhao V. Wang
25. Autophagy, exercise and life style modification
Donny Camera and William J. Smiles
Product details
- No. of pages: 340
- Language: English
- Copyright: © Academic Press 2018
- Published: April 12, 2018
- Imprint: Academic Press
- Paperback ISBN: 9780128052532
- eBook ISBN: 9780128054420
About the Authors
Jun Ren
Affiliations and Expertise
James R. Sowers
Affiliations and Expertise
Yingmei Zhang
Affiliations and Expertise
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