Autoimmunity, COVID-19, Post-COVID19 Syndrome and COVID-19 Vaccination

Autoimmunity, COVID-19, Post-COVID19 Syndrome and COVID-19 Vaccination

1st Edition - December 15, 2022

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  • Editors: Yehuda Shoenfeld, Arad Dotan
  • Paperback ISBN: 9780443185663

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Autoimmunity, COVID-19, Post-COVID-19 Syndrome and COVID-19 Vaccination covers all aspects of what is perhaps the most dramatic health crisis in the history of modern medicine. Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) raised major concerns about the association between the virus and various autoimmune manifestations. Over 15 distinct autoantibodies and above 10 different autoimmune diseases were found to develop in COVID-19 patients. Moreover, evidence about recovered COVID-19 patients demonstrates that persistent systemic symptoms, which are believed to have an autoimmune-related mechanism, do exist. As it is of great importance to recognize those autoimmune manifestations of COVID-19 and post-COVID-19 syndrome to properly cope with their outcomes in the ongoing pandemic and the long-term post-pandemic period, this book fulfills a vital need in the medical community.

Key Features

  • Describe the short and long impact of COVID-19 on autoimmunity
  • Provides understanding to the acute and chronic impact of the SARS-CoV-2
  • Gives insights into the long-term effects of COVID-19 on recovered patients
  • Provides conclusions on the novel terms "chronic post-COVID-19 syndrome", "post-acute COVID-19 syndrome", and "long COVID-19"


Researchers, clinicians, clinical investigators, pathologists, medical students, and graduate students in the biomedical sciences, as well as basic scientists in such fields as immunology, and virology, clinical investigators and policy makers

Table of Contents

  • 1. Introduction
    The SARS-CoV-2 as an instrumental trigger of autoimmunity
    The mosaic of autoimmunity: SARS-CoV- as an environmental factor

    2. Cellular and molecular mechanisms in COVID-19
    Innate immunity
    Adaptive immunity
    Cytokines and chemokines
    Genetic predisposition
    Molecular mimicry
    Hyperferritinemic syndromes

    3. Autoantibodies in COVID-19
    Autoantibodies as a pre-clinical phase of autoimmunity
    Coagulation dysfunction related autoaintibodies
    Classical autoantibodies (ANA, RF, Ro52, anti-Ro60, p-ANCA, c-ANCA, etc
    Antibodies could be driving severe COVID-19: Anti-interferon autoantibodies
    ACE-2 receptor: the port of entry to the cell Anti ACE-2 F

    4. Autoimmune manifestations and diseases in COVID-19
    Humeral disorders and thrombosis
    Rheumatic diseases
    Kawasaki-like disease
    Additional immune-mediated manifestations

    5. Peculiar aspects in COVID-19
    Gender impact on COVID-19
    Microbiome and COVID-19
    Fertility related autoantibodies and Reproductive injury
    COVID-19 and pregnancy
    Side effects of the COVID-19 vaccines

    6. Chronic post-COVID-19 syndromes
    Disease course and mechanisms
    Autoantibodies against the adrenergic nervous system
    Long-term assessment of autoantibodies in COVID-19
    Symptoms, diagnosis and epidemiology
    Treatment and Prevention

Product details

  • No. of pages: 830
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: December 15, 2022
  • Imprint: Academic Press
  • Paperback ISBN: 9780443185663

About the Editors

Yehuda Shoenfeld

Yehuda Shoenfeld
Professor Yehuda Shoenfeld is the President of the Center for Autoimmune Diseases (present), incumbent of the Laura Schwarz-Kipp Chair for Research of Autoimmune Diseases in Tel Aviv University (since 2002–Present), Emeritus Professor of the Sackler School of Medicine in Tel Aviv University and teaches medical studies and MSc and PhD students (since 1985). Prof. Shoenfeld has edited a series of textbooks entailing "The Mosaic of Autoimmunity," "Autoantibodies," "Infection and Autoimmunity," and "Diagnostic Criteria of Autoimmune Diseases" (Elsevier Pub.). He has served on 36 editorial boards and is the organizer of more than 25 international congresses on autoimmunity. He is the author of > 2000 peer-reviewed papers reported in the field of autoimmunity and internal medicine. More than 65,000 citations.

Affiliations and Expertise

President of the Center for Autoimmune diseases (Present). Incumbent of the Laura Schwarz-Kipp Chair for Research of Autoimmune Diseases in Tel-Aviv University (since 2002 – Present)

Arad Dotan

Dr. Dotan has Bachelor of Medical Sciences from Ben Gurion University Medical School.and has a master in Master of Public Health (MPH) - Sackler Faculty of Medicine, Tel Aviv University. Currently he is researcher at Zabludowicz Center for Autoimmune Diseases, Sheba Medical Center, Tel-Hashomer; instructor: Prof. Yehuda Shoenfeld.

Affiliations and Expertise

Medical Doctor, Chaim Sheba Medical Center, Sheba Medical Center, Ramat Gan, Sackler Faculty of Medicine, Tel-Aviv University, Israel

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