
Atlas of Hematopathology
Morphology, Immunophenotype, Cytogenetics, and Molecular Approaches
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As the definitive diagnostic atlas of the diseases of the hematopoietic system, the Atlas of Hematopathology appeals to a wide range of people who are being trained in a variety of medical fields or practicing as non-hematopathologists, and therefore, are looking for a book which can provide information in a clear, focused format, with no excessive text or details. The atlas offers effective guidance in evaluating specimens from the lymph nodes, bone marrow, spleen, and peripheral blood, enabling clinicians to deliver more accurate and actionable pathology reports. Practicing physicians and those in pathology and hematology training also gain a better understanding of the nature of hematologic disorders and improve their diagnostic skills along the way. Taking a unique multi-disciplinary approach, the book covers conventional histopathology and cytopathology, as well as all important complementary diagnostic tests, such as immunophenotyping (immunohistochemical stains and flow cytometry), karyotyping, FISH and DNA/molecular studies. It offers concise textual and extensive visual coverage of both neoplastic and non-neoplastic hematology disorders, with the neoplastic hematology sections presented according to the most recent WHO classifications. There is also an introduction to the normal structures of hematopoietic tissues and the various multidisciplinary techniques. The atlas contains more than 900 high-quality color images that mirror the findings that fellows and clinicians encounter in practice. It provides information in a quick, simple and user-friendly manner, attracting those who are in training or are not considered experts in the field. Residents, fellows, practicing clinicians, and researchers in pathology, hematology, hematology/oncology, as well as graduate students in pathology and other clinicians workings in clinical hematology laboratories will all find it useful.
Key Features
- Saves clinicians and researchers time in quickly accessing the very latest details on the diverse clinical and scientific aspects of hematopathology, as opposed to searching through thousands of journal articles
- For clinicians, fellows, and residents, correct diagnosis (and therefore correct treatment) of diseases depends on a strong understanding of the molecular basis for the disease – hematologists, pathologists, oncologists, and other clinicians will benefit from this clear, focused, annotated format
- Companion web site features over 900 images from the book!
Readership
Residents, fellows, practicing clinicians, and researchers in pathology, hematology, hematology/oncology, as well as graduate students in pathology and other clinicians workings in clinical hematology laboratories
Table of Contents
- Preface
Acknowledgments
1. Structure and Function of Hematopoietic Tissues
Bone Marrow Examination
Morphologic Characteristics of Bone Marrow Cells
Blood Smear Examination
Structure and Function of the Spleen
Structure and Function of the Lymph Nodes
Extramedullary Hematopoiesis
Additional Resources
2. Principles of Immunophenotyping
Human Cell Differentiation Molecules
Principles of Flow Cytometry
Principles of Immunohistochemistry
Additional Resources
3. Principles of Cytogenetics
Introduction
Cell Preparation
Banding Techniques
Analysis
Conclusions
Additional Resources
4. Principles of Molecular Techniques
Fluorescence In Situ Hybridization
Polymerase Chain Reaction and Related Techniques
Blotting Techniques
Microarray Techniques
DNA Sequencing
Additional Resources
5. Morphology of Abnormal Bone Marrow
Gelatinous Transformation
Bone Marrow Necrosis
Amyloidosis
Granulomas
Bone Marrow Metastasis
Bone and Stromal Changes
Additional Resources
6. Reactive Lymphadenopathies
Follicular Pattern
Paracortical (Interfollicular) Pattern
Sinus Pattern
Granulomatous Lymphadenitis
Mixed Pattern
Additional Resources
7. Bone Marrow Aplasia
Fanconi Anemia
Other Congenital Bone Marrow Aplasias
Acquired Aplastic Anemia
Paroxysmal Nocturnal Hemoglobinuria
Differential Diagnosis
Additional Resources
8. Myelodysplastic Syndromes/Neoplasms—Overview
Morphologic Features—Overview
Immunophenotype
Molecular Studies
Cytogenetics
Additional Resources
9. Myelodysplastic Syndromes/Neoplasms—Classification
Refractory Cytopenia with Unilineage Dysplasia
Refractory Anemia with Ring Sideroblasts
Refractory Cytopenia with Multilineage Dysplasia
Refractory Anemia with Excess Blasts
Myelodysplastic Syndrome with Isolated Del(5q)
Myelodysplastic Syndrome, Unclassifiable
Other Types of Myelodysplastic Syndromes
Non-Clonal Myelodysplasia
Differential Diagnosis
Additional Resourses
10. Myeloproliferative Neoplasms—Overview
Morphology
Immunophenotype
Molecular Studies
Cytogenetics
Additional Resources
11. Chronic Myelogenous Leukemia
Morphology and Laboratory Findings
Immunophenotype
Molecular Studies
Cytogenetics
Differential Diagnosis
Additional Resources
12. Myeloproliferative Neoplasms Associated with JAK2 Mutation
Polycythemia Vera
Primary Myelofibrosis
Essential Thrombocythemia
Differential Diagnosis
Additional Resources
13. Chronic Neutrophilic and Chronic Eosinophilic Leukemias
Chronic Neutrophilic Leukemia
Chronic Eosinophilic Leukemia, Not Otherwise Specified
Additional Resources
14. Mastocytosis
Morphology and Laboratory Findings
Immunophenotypic Studies
Molecular and Cytogenetic Studies
Classification
Differential Diagnosis
Additional Resources
15. Myelodysplastic/Myeloproliferative Neoplasms
Chronic Myelomonocytic Leukemia
Atypical Chronic Myeloid Leukemia
Juvenile Myelomonocytic Leukemia
Differential Diagnosis
Additional Resources
16. Hematologic Neoplasms Associated with Eosinophilia and PDGFRA, PDGFRB, or FGFR1 Rearrangement
Myeloid and Lymphoid Neoplasms Associated with PDGFRA Rearrangement
Myeloid Neoplasms Associated with PDGFRB Rearrangement
Myeloid and Lymphoid Neoplasms Associated with FGFR1 Rearrangements
Additional Resources
17. Acute Myeloid Leukemia—Overview
Morphology
Cytochemical Stains
Immunophenotypic Studies
Molecular Studies
Cytogenetics
Additional Resources
18. Acute Myeloid Leukemias with Recurrent Genetic Abnormalities
AML with Chromosomally Balanced Rearrangements: Translocations/Inversions
AML with Gene Mutations
Differential Diagnosis
Additional Resources
19. Acute Myeloid Leukemia with Myelodysplasia-Related Changes
Morphology (Figures 19.1 to 19.4)
Immunophenotype
Molecular and Cytogenetic Studies
Differential Diagnosis
Additional Resources
20. Therapy-Related Myeloid Neoplasms
Alkylating Agent/Radiation-Related Myeloid Neoplasms
Topoisomerase II Inhibitor- Related AML
Differential Diagnosis
Additional Resources
21. Acute Myeloid Leukemia, Not Otherwise Specified
AML, Minimally Differentiated
AML without Maturation
AML with Maturation
Acute Myelomonocytic Leukemia
Acute Monoblastic and Acute Monocytic Leukemias
Acute Erythroid Leukemias
Acute Megakaryoblastic Leukemia
Acute Basophilic Leukemia
Acute Panmyelosis with Myelofibrosis
Other Types of Acute Myeloid Leukemia
Additional Resources
22. Myeloid Proliferations Related to Down Syndrome
Transient Abnormal Myelopoiesis
DS-Associated Myeloid Leukemias
Additional Resources
23. Lymphoblastic Neoplasms—B-Lymphoblastic Leukemia/Lymphoma
Common Morphologic and Cytochemical Features
B-Lymphoblastic Leukemia/Lymphoma with Recurrent Genetic Abnormalities
B-Lymphoblastic Leukemia/Lymphoma, Not Otherwise Specified
Differential Diagnosis
Additional Resources
24. Lymphoblastic Neoplasms—T-Lymphoblastic Leukemia/Lymphoma
Morphology
Immunophenotype and Cytochemical Stains
Cytogenetic and Molecular Studies
Rare Variants of Lymphoblastic Leukemia/Lymphoma
Differential Diagnosis
Additional Resources
25. Acute Leukemias of Ambiguous Lineage
Acute Undifferentiated Leukemia
Mixed Phenotype Acute Leukemia
Differential Diagnosis
Additional Resources
26. Mature B-Cell Neoplasms—Overview
Morphology
Immunophenotype
Cytogenetics and Molecular Studies
Differential Diagnosis
Additional Resources
27. Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
Morphology
Immunophenotype
Cytogenetic and Molecular Studies
Variants of CLL/SLL
Transformation of CLL to a More Aggressive Disease (Richter Syndrome)
Differential Diagnosis
Additional Resources
28. B-Cell Prolymphocytic Leukemia
Morphology
Immunophenotype
Cytogenetic and Molecular Studies
Differential Diagnosis
Additional Resources
29. Lymphoplasmacytic Lymphoma/Waldenström’s Macroglobulinemia
Morphology and Laboratory Findings (Figures 29.1 to 29.5)
Immunophenotype
Cytogenetic and Molecular Studies
Differential Diagnosis
Additional Resources
30. Hairy Cell Leukemia
Morphology
Immunophenotype and Cytochemical Stains
Molecular and Cytogenetic Studies
HCL Variants
Differential Diagnosis
Additional Resources
31. Splenic Marginal Zone Lymphoma
Morphology
Immunophenotype
Cytogenetic and Molecular Studies
Other Splenic B-Cell Lymphomas
Differential Diagnosis
Additional Resources
32. Nodal Marginal Zone Lymphoma
Morphology
Immunophenotype
Molecular and Cytogenetic Studies
Pediatric Nodal Marginal Zone Lymphoma
Differential Diagnosis
Additional Resources
33. Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue (MALT Lymphoma)
Morphology
Immunophenotype
Cytogenetic and Molecular Studies
Differential Diagnosis
Additional Resourses
34. Follicular Lymphoma
Morphology
Immunophenotype
Cytogenetic and Molecular Studies
Variants of Follicular Lymphoma
Differential Diagnosis
Additional Resources
35. Mantle Cell Lymphoma
Morphology
Immunophenotype
Cytogenetic and Molecular Studies
Indolent Variant of MCL
Differential Diagnosis
Additional Resources
36. Diffuse Large B-Cell Lymphoma
Morphology and Laboratory Findings
Immunophenotype
Molecular and Cytogenetic Studies
Differential Diagnosis
Additional Resources
37. Diffuse Large B-Cell Lymphoma Subtypes
T-Cell/Histiocyte-Rich Large B-Cell Lymphoma
EBV+ Diffuse Large B-Cell Lymphoma of the Elderly
Primary DLBCL of the CNS
Additional Resources
38. Other Lymphomas of Large B Cells
Primary Mediastinal (Thymic) Large B-Cell Lymphoma
Intravascular Large B-Cell Lymphoma
Diffuse Large B-Cell Lymphoma Associated with Chronic Inflammation
Lymphomatoid Granulomatosis
ALK-Positive Large B-Cell Lymphoma
Primary Effusion Lymphoma
Plasmablastic Lymphoma
Large B-Cell Lymphoma Arising in HHV8-Associated Multicentric Castleman Disease
HHV8- and EBV-Associated Germinotropic Lymphoproliferative Disorder
B-Cell Lymphoma, Unclassifiable, with Features Intermediate between DLBCL and Classical Hodgkin Lymphoma
Additional Resources
39. Burkitt Lymphoma
Burkitt Lymphoma
B-Cell Lymphoma, Unclassifiable, with Features Intermediate Between Diffuse Large B-Cell Lymphoma and Burkitt Lymphoma
Additional Resources
40. Primary Cutaneous B-Cell Lymphomas
Primary Cutaneous Follicle Center Lymphoma
Primary Cutaneous Marginal Zone Lymphoma
Primary Cutaneous Diffuse Large B-Cell Lymphoma–Leg Type
Plasmacytoma
Additional Resources
41. Plasma Cell Neoplasms
Monoclonal Gammopathy of Undetermined Significance
Plasma Cell Myeloma
Osteosclerotic Myeloma
Plasmacytoma
Deposition Diseases
Additional Resources
42. Mature T- and NK-Cell Neoplasms—Overview
T-Cells
NK-cells
Classification
Additional Resources
43. Large Granular Lymphocytic Neoplasms and Related Disorders
T-Cell Large Granular Lymphocytic Leukemia
Chronic Lymphoproliferative Disorder of NK Cells
Aggressive NK-Cell Leukemia
Extranodal NK/T-Cell Lymphoma, Nasal Type
EBV-Associated T/NK-Cell Lymphoproliferative Disorder of Children and Young Adults
Differential Diagnosis
Additional Resources
44. T-Cell Prolymphocytic Leukemia
Morphology
Immunophenotype
Cytogenetic and Molecular Studies
Differential Diagnosis
Additional Resources
45. Adult T-Cell Leukemia/Lymphoma
Morphology
Immunophenotype
Molecular and Cytogenetic Studies
Differential Diagnosis
Additional Resources
46. Hepatosplenic T-Cell Lymphoma
Morphology
Immunophenotype
Molecular and Cytogenetic Studies
Differential Diagnosis
Additional Resources
47. Enteropathy-Associated T-Cell Lymphoma
Morphology
Immunophenotype
Molecular and Cytogenetic Studies
Differential Diagnosis
Additional Resources
48. Mycosis Fungoides and Sézary Syndrome
Mycosis Fungoides
Sézary Syndrome
Differential Diagnosis
Additional Resources
49. Other Primary Cutaneous T-Cell Lymphoproliferative Disorders
Primary Cutaneous CD30-Positive T-Cell Lymphoproliferative Disorders
Subcutaneous Panniculitis-Like T-Cell Lymphoma
Cutaneous γδ T-Cell Lymphoma
Primary Cutaneous Aggressive Epidermotropic CD8+ Cytotoxic T-Cell Lymphoma
Primary Cutaneous CD4+ Small/Medium T-Cell Lymphoma
Epstein–Barr Virus-Associated Hydroa Vacciniforme-Like Cutaneous Lymphoma of Childhood
Differential Diagnosis
Additional Resources
50. Angioimmunoblastic T-Cell Lymphoma
Morphology and Laboratory Findings
Immunophenotype
Molecular and Cytogenetic Studies
Differential Diagnosis
Additional Resources
51. Anaplastic Large Cell Lymphomas
Anaplastic Large Cell Lymphoma, ALK-Positive
Anaplastic Large Cell Lymphoma, ALK-Negative
Borderline Cases
Differential Diagnosis
Additional Resources
52. Peripheral T-Cell Lymphoma, Not Otherwise Specified
Morphology
Immunophenotype
Molecular and Cytogenetic Studies
Differential Diagnosis
Additional Resources
53. Nodular Lymphocyte Predominant Hodgkin Lymphoma
Overview of Hodgkin Lymphoma
Nodular Lymphocyte Predominant Hodgkin Lymphoma
Additional Resources
54. Classical Hodgkin Lymphoma
Nodular Sclerosis Classical Hodgkin Lymphoma
Mixed Cellularity Classical Hodgkin Lymphoma
Lymphocyte-Rich Classical Hodgkin Lymphoma
Lymphocyte-Depleted Classical Hodgkin Lymphoma
Differential Diagnosis
Additional Resources
55. Immunodeficiency Disorders
Primary Immunodeficiency Syndromes
Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome
Idiopathic CD4+ T-Lymphocytopenia
Additional Resources
56. Iatrogenic Immunodeficiency-Associated Lymphoproliferative Disorders
Post-Transplant Lymphoproliferative Disorders
Other Iatrogenic Immunodeficiency-Associated Lymphoproliferative Disorders
Additional Resources
57. Lymphocytopenia and Lymphocytosis
Lymphocytopenia
Lymphocytosis
Additional Resources
58. Histiocytic Disorders
Gaucher Disease
Niemann–Pick Disease
Chédiak–Higashi Syndrome
Monocytopenia and Monocytosis
Reactive Histiocytic Proliferations
Hemophagocytic Lymphohistiocytosis
Histiocytic Sarcoma
Additional Resources
59. Disorders of Dendritic Cells
Langerhans Cell Histiocytosis
Langerhans Cell Sarcoma
Blastic Plasmacytoid Dendritic Cell Neoplasm
Interdigitating Dendritic Cell Sarcoma
Follicular Dendritic Cell Sarcoma
Additional Resources
60. Granulocytic Disorders
Morphologic Abnormalities
Functional Abnormalities
Neutropenia
Neutrophilia
Eosinophilia
Basophilia
Additional Resources
61. Disorders of Red Blood Cells—Anemias
Pure Red Cell Aplasia
Congenital Dyserythropoietic Anemias
Macrocytic Anemias
Microcytic Anemias
Sickle Cell Disease
Other Hemoglobinopathies
Erythrocyte Membrane Skeleton Defects
Hemolytic Anemia Secondary to Erythrocyte Enzyme Deficiencies
Immune-Mediated Hemolytic Anemia
Acquired Non-Immune Hemolytic Anemias
Other Types of Anemia
Additional Resources
62. Disorders of Megakaryocytes and Platelets
Megakaryocytic Hypoplasia
Megakaryocytosis
Thrombocytopenia
Qualitative Disorders of Platelets and Megakaryocytes
Disorders of Platelet Secretion and Granule Deficiencies
Acquired Platelet Disorders
Additional Resources
63. Post-Therapy Changes
Changes Associated with Hematopoietic Stem Cell Transplantation
Post Chemotherapy and Irradiation Changes
Cytokine-Associated Bone Marrow Changes
Changes Associated with Application of Monoclonal Antibodies
Changes Associated with Imatinib Mesylate (Gleevec) Therapy
Minimal Residual Disease
Additional Resources
Index
Product details
- No. of pages: 756
- Language: English
- Copyright: © Academic Press 2012
- Published: December 21, 2012
- Imprint: Academic Press
- eBook ISBN: 9780123851840
About the Author
Faramarz Naeim
Dr. Faramarz Naeim is Professor Emeritus of Pathology, David Geffen School of Medicine, UCLA. He graduated from Tehran University School of Medicine and received his training in Pathology at Mallory Institute of Pathology, Boston City Hospital and Department of Pathology at UCLA School of Medicine. He has provided clinical services as a hematopathologist for 43 years, 30 years at UCLA, Department of Pathology and Laboratory Medicine, and 13 years at VA Greater Los Angeles Healthcare System, Department of Pathology and Laboratory Medicine. Dr. Naeim has published several books and book chapters in hematopathology and numerous articles in peer review journals.
Affiliations and Expertise
Professor Emeritus, Department of Pathology, David Geffen UCLA School of Medicine, Hematopathologist, Department of Pathology and Laboratory Medicine, VA Greater Los Angeles Healthcare System, Los Angeles, California