Atlas of Hematopathology

1st Edition

Morphology, Immunophenotype, Cytogenetics, and Molecular Approaches

Authors: Faramarz Naeim
Hardcover ISBN: 9780123851833
eBook ISBN: 9780123851840
Imprint: Academic Press
Published Date: 21st December 2012
Page Count: 756
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As the definitive diagnostic atlas of the diseases of the hematopoietic system, the Atlas of Hematopathology appeals to a wide range of people who are being trained in a variety of medical fields or practicing as non-hematopathologists, and therefore, are looking for a book which can provide information in a clear, focused format, with no excessive text or details. The atlas offers effective guidance in evaluating specimens from the lymph nodes, bone marrow, spleen, and peripheral blood, enabling clinicians to deliver more accurate and actionable pathology reports. Practicing physicians and those in pathology and hematology training also gain a better understanding of the nature of hematologic disorders and improve their diagnostic skills along the way.

Taking a unique multi-disciplinary approach, the book covers conventional histopathology and cytopathology, as well as all important complementary diagnostic tests, such as immunophenotyping (immunohistochemical stains and flow cytometry), karyotyping, FISH and DNA/molecular studies. It offers concise textual and extensive visual coverage of both neoplastic and non-neoplastic hematology disorders, with the neoplastic hematology sections presented according to the most recent WHO classifications. There is also an introduction to the normal structures of hematopoietic tissues and the various multidisciplinary techniques.

The atlas contains more than 900 high-quality color images that mirror the findings that fellows and clinicians encounter in practice. It provides information in a quick, simple and user-friendly manner, attracting those who are in training or are not considered experts in the field. Residents, fellows, practicing clinicians, and researchers in pathology, hematology, hematology/oncology, as well as graduate students in pathology and other clinicians workings in clinical hematology laboratories will all find it useful.

Key Features

  • Saves clinicians and researchers time in quickly accessing the very latest details on the diverse clinical and scientific aspects of hematopathology, as opposed to searching through thousands of journal articles
  • For clinicians, fellows, and residents, correct diagnosis (and therefore correct treatment) of diseases depends on a strong understanding of the molecular basis for the disease – hematologists, pathologists, oncologists, and other clinicians will benefit from this clear, focused, annotated format
  • Companion web site features over 900 images from the book!


Residents, fellows, practicing clinicians, and researchers in pathology, hematology, hematology/oncology, as well as graduate students in pathology and other clinicians workings in clinical hematology laboratories.

Table of Contents



1. Structure and Function of Hematopoietic Tissues

Bone Marrow Examination

Morphologic Characteristics of Bone Marrow Cells

Blood Smear Examination

Structure and Function of the Spleen

Structure and Function of the Lymph Nodes

Extramedullary Hematopoiesis

Additional Resources

2. Principles of Immunophenotyping

Human Cell Differentiation Molecules

Principles of Flow Cytometry

Principles of Immunohistochemistry

Additional Resources

3. Principles of Cytogenetics


Cell Preparation

Banding Techniques



Additional Resources

4. Principles of Molecular Techniques

Fluorescence In Situ Hybridization

Polymerase Chain Reaction and Related Techniques

Blotting Techniques

Microarray Techniques

DNA Sequencing

Additional Resources

5. Morphology of Abnormal Bone Marrow

Gelatinous Transformation

Bone Marrow Necrosis



Bone Marrow Metastasis

Bone and Stromal Changes

Additional Resources

6. Reactive Lymphadenopathies

Follicular Pattern

Paracortical (Interfollicular) Pattern

Sinus Pattern

Granulomatous Lymphadenitis

Mixed Pattern

Additional Resources

7. Bone Marrow Aplasia

Fanconi Anemia

Other Congenital Bone Marrow Aplasias

Acquired Aplastic Anemia

Paroxysmal Nocturnal Hemoglobinuria

Differential Diagnosis

Additional Resources

8. Myelodysplastic Syndromes/Neoplasms—Overview

Morphologic Features—Overview


Molecular Studies


Additional Resources

9. Myelodysplastic Syndromes/Neoplasms—Classification

Refractory Cy


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© Academic Press 2013
Academic Press
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About the Author

Faramarz Naeim

Dr. Naeim has over 25 years practice in bone marrow pathology with several years of experience in flow cytometry. He is the author of numerous research articles and an established Elsevier author. He is a hematopathologist and an internationally known expert in pathology of bone marrow disorders. He is currently the Head of Hematopathology and the Director of Hematopathology Fellowship program at David Geffen School of Medicine, UCLA.

Affiliations and Expertise

Professor of Pathology and Chief of Hematopathology, Department of Pathology and Laboratory Medicine, UCLA Medical Center, Los Angeles, CA, USA MD, FASCP Professor Emeritus, David Geffen School of Medicine, UCLA Director of Hematopathology, Department of Pathology and Laboratory Medicine VA Greater Los Angeles Healthcare System, Los Angeles, California


"This 2nd edition, a revision of Hematopathology, has a multidisciplinary approach, in that it goes beyond illustrating standard histology and cytopathology to demonstrating other complementary diagnostic tests, e.g., DNA/molecular studies and immunophenotyping. In addition, it is comprehensive as it treats both neoplastic and non-neoplastic pathology in tissues and organs."--Reference and Research Book News, August 2013
"This would be useful to those looking for a book that concisely covers both non-neoplastic and neoplastic hematopathology. It also would be useful to visual learners who appreciate numerous photos, charts, and diagrams.", June 13, 2013