Atlas of Hematopathology

Atlas of Hematopathology

Morphology, Immunophenotype, Cytogenetics, and Molecular Approaches

1st Edition - December 21, 2012

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  • Author: Faramarz Naeim
  • eBook ISBN: 9780123851840

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Description

As the definitive diagnostic atlas of the diseases of the hematopoietic system, the Atlas of Hematopathology appeals to a wide range of people who are being trained in a variety of medical fields or practicing as non-hematopathologists, and therefore, are looking for a book which can provide information in a clear, focused format, with no excessive text or details. The atlas offers effective guidance in evaluating specimens from the lymph nodes, bone marrow, spleen, and peripheral blood, enabling clinicians to deliver more accurate and actionable pathology reports. Practicing physicians and those in pathology and hematology training also gain a better understanding of the nature of hematologic disorders and improve their diagnostic skills along the way. Taking a unique multi-disciplinary approach, the book covers conventional histopathology and cytopathology, as well as all important complementary diagnostic tests, such as immunophenotyping (immunohistochemical stains and flow cytometry), karyotyping, FISH and DNA/molecular studies. It offers concise textual and extensive visual coverage of both neoplastic and non-neoplastic hematology disorders, with the neoplastic hematology sections presented according to the most recent WHO classifications. There is also an introduction to the normal structures of hematopoietic tissues and the various multidisciplinary techniques. The atlas contains more than 900 high-quality color images that mirror the findings that fellows and clinicians encounter in practice. It provides information in a quick, simple and user-friendly manner, attracting those who are in training or are not considered experts in the field. Residents, fellows, practicing clinicians, and researchers in pathology, hematology, hematology/oncology, as well as graduate students in pathology and other clinicians workings in clinical hematology laboratories will all find it useful.

Key Features

  • Saves clinicians and researchers time in quickly accessing the very latest details on the diverse clinical and scientific aspects of hematopathology, as opposed to searching through thousands of journal articles
  • For clinicians, fellows, and residents, correct diagnosis (and therefore correct treatment) of diseases depends on a strong understanding of the molecular basis for the disease – hematologists, pathologists, oncologists, and other clinicians will benefit from this clear, focused, annotated format
  • Companion web site features over 900 images from the book!

Readership

Residents, fellows, practicing clinicians, and researchers in pathology, hematology, hematology/oncology, as well as graduate students in pathology and other clinicians workings in clinical hematology laboratories

Table of Contents

  • Preface
    Acknowledgments
    1. Structure and Function of Hematopoietic Tissues
    Bone Marrow Examination
    Morphologic Characteristics of Bone Marrow Cells
    Blood Smear Examination
    Structure and Function of the Spleen
    Structure and Function of the Lymph Nodes
    Extramedullary Hematopoiesis
    Additional Resources
    2. Principles of Immunophenotyping
    Human Cell Differentiation Molecules
    Principles of Flow Cytometry
    Principles of Immunohistochemistry
    Additional Resources
    3. Principles of Cytogenetics
    Introduction
    Cell Preparation
    Banding Techniques
    Analysis
    Conclusions
    Additional Resources
    4. Principles of Molecular Techniques
    Fluorescence In Situ Hybridization
    Polymerase Chain Reaction and Related Techniques
    Blotting Techniques
    Microarray Techniques
    DNA Sequencing
    Additional Resources
    5. Morphology of Abnormal Bone Marrow
    Gelatinous Transformation
    Bone Marrow Necrosis
    Amyloidosis
    Granulomas
    Bone Marrow Metastasis
    Bone and Stromal Changes
    Additional Resources
    6. Reactive Lymphadenopathies
    Follicular Pattern
    Paracortical (Interfollicular) Pattern
    Sinus Pattern
    Granulomatous Lymphadenitis
    Mixed Pattern
    Additional Resources
    7. Bone Marrow Aplasia
    Fanconi Anemia
    Other Congenital Bone Marrow Aplasias
    Acquired Aplastic Anemia
    Paroxysmal Nocturnal Hemoglobinuria
    Differential Diagnosis
    Additional Resources
    8. Myelodysplastic Syndromes/Neoplasms—Overview
    Morphologic Features—Overview
    Immunophenotype
    Molecular Studies
    Cytogenetics
    Additional Resources
    9. Myelodysplastic Syndromes/Neoplasms—Classification
    Refractory Cytopenia with Unilineage Dysplasia
    Refractory Anemia with Ring Sideroblasts
    Refractory Cytopenia with Multilineage Dysplasia
    Refractory Anemia with Excess Blasts
    Myelodysplastic Syndrome with Isolated Del(5q)
    Myelodysplastic Syndrome, Unclassifiable
    Other Types of Myelodysplastic Syndromes
    Non-Clonal Myelodysplasia
    Differential Diagnosis
    Additional Resourses
    10. Myeloproliferative Neoplasms—Overview
    Morphology
    Immunophenotype
    Molecular Studies
    Cytogenetics
    Additional Resources
    11. Chronic Myelogenous Leukemia
    Morphology and Laboratory Findings
    Immunophenotype
    Molecular Studies
    Cytogenetics
    Differential Diagnosis
    Additional Resources
    12. Myeloproliferative Neoplasms Associated with JAK2 Mutation
    Polycythemia Vera
    Primary Myelofibrosis
    Essential Thrombocythemia
    Differential Diagnosis
    Additional Resources
    13. Chronic Neutrophilic and Chronic Eosinophilic Leukemias
    Chronic Neutrophilic Leukemia
    Chronic Eosinophilic Leukemia, Not Otherwise Specified
    Additional Resources
    14. Mastocytosis
    Morphology and Laboratory Findings
    Immunophenotypic Studies
    Molecular and Cytogenetic Studies
    Classification
    Differential Diagnosis
    Additional Resources
    15. Myelodysplastic/Myeloproliferative Neoplasms
    Chronic Myelomonocytic Leukemia
    Atypical Chronic Myeloid Leukemia
    Juvenile Myelomonocytic Leukemia
    Differential Diagnosis
    Additional Resources
    16. Hematologic Neoplasms Associated with Eosinophilia and PDGFRA, PDGFRB, or FGFR1 Rearrangement
    Myeloid and Lymphoid Neoplasms Associated with PDGFRA Rearrangement
    Myeloid Neoplasms Associated with PDGFRB Rearrangement
    Myeloid and Lymphoid Neoplasms Associated with FGFR1 Rearrangements
    Additional Resources
    17. Acute Myeloid Leukemia—Overview
    Morphology
    Cytochemical Stains
    Immunophenotypic Studies
    Molecular Studies
    Cytogenetics
    Additional Resources
    18. Acute Myeloid Leukemias with Recurrent Genetic Abnormalities
    AML with Chromosomally Balanced Rearrangements: Translocations/Inversions
    AML with Gene Mutations
    Differential Diagnosis
    Additional Resources
    19. Acute Myeloid Leukemia with Myelodysplasia-Related Changes
    Morphology (Figures 19.1 to 19.4)
    Immunophenotype
    Molecular and Cytogenetic Studies
    Differential Diagnosis
    Additional Resources
    20. Therapy-Related Myeloid Neoplasms
    Alkylating Agent/Radiation-Related Myeloid Neoplasms
    Topoisomerase II Inhibitor- Related AML
    Differential Diagnosis
    Additional Resources
    21. Acute Myeloid Leukemia, Not Otherwise Specified
    AML, Minimally Differentiated
    AML without Maturation
    AML with Maturation
    Acute Myelomonocytic Leukemia
    Acute Monoblastic and Acute Monocytic Leukemias
    Acute Erythroid Leukemias
    Acute Megakaryoblastic Leukemia
    Acute Basophilic Leukemia
    Acute Panmyelosis with Myelofibrosis
    Other Types of Acute Myeloid Leukemia
    Additional Resources
    22. Myeloid Proliferations Related to Down Syndrome
    Transient Abnormal Myelopoiesis
    DS-Associated Myeloid Leukemias
    Additional Resources
    23. Lymphoblastic Neoplasms—B-Lymphoblastic Leukemia/Lymphoma
    Common Morphologic and Cytochemical Features
    B-Lymphoblastic Leukemia/Lymphoma with Recurrent Genetic Abnormalities
    B-Lymphoblastic Leukemia/Lymphoma, Not Otherwise Specified
    Differential Diagnosis
    Additional Resources
    24. Lymphoblastic Neoplasms—T-Lymphoblastic Leukemia/Lymphoma
    Morphology
    Immunophenotype and Cytochemical Stains
    Cytogenetic and Molecular Studies
    Rare Variants of Lymphoblastic Leukemia/Lymphoma
    Differential Diagnosis
    Additional Resources
    25. Acute Leukemias of Ambiguous Lineage
    Acute Undifferentiated Leukemia
    Mixed Phenotype Acute Leukemia
    Differential Diagnosis
    Additional Resources
    26. Mature B-Cell Neoplasms—Overview
    Morphology
    Immunophenotype
    Cytogenetics and Molecular Studies
    Differential Diagnosis
    Additional Resources
    27. Chronic Lymphocytic Leukemia/Small Lymphocytic Lymphoma
    Morphology
    Immunophenotype
    Cytogenetic and Molecular Studies
    Variants of CLL/SLL
    Transformation of CLL to a More Aggressive Disease (Richter Syndrome)
    Differential Diagnosis
    Additional Resources
    28. B-Cell Prolymphocytic Leukemia
    Morphology
    Immunophenotype
    Cytogenetic and Molecular Studies
    Differential Diagnosis
    Additional Resources
    29. Lymphoplasmacytic Lymphoma/Waldenström’s Macroglobulinemia
    Morphology and Laboratory Findings (Figures 29.1 to 29.5)
    Immunophenotype
    Cytogenetic and Molecular Studies
    Differential Diagnosis
    Additional Resources
    30. Hairy Cell Leukemia
    Morphology
    Immunophenotype and Cytochemical Stains
    Molecular and Cytogenetic Studies
    HCL Variants
    Differential Diagnosis
    Additional Resources
    31. Splenic Marginal Zone Lymphoma
    Morphology
    Immunophenotype
    Cytogenetic and Molecular Studies
    Other Splenic B-Cell Lymphomas
    Differential Diagnosis
    Additional Resources
    32. Nodal Marginal Zone Lymphoma
    Morphology
    Immunophenotype
    Molecular and Cytogenetic Studies
    Pediatric Nodal Marginal Zone Lymphoma
    Differential Diagnosis
    Additional Resources
    33. Extranodal Marginal Zone Lymphoma of Mucosa-Associated Lymphoid Tissue (MALT Lymphoma)
    Morphology
    Immunophenotype
    Cytogenetic and Molecular Studies
    Differential Diagnosis
    Additional Resourses
    34. Follicular Lymphoma
    Morphology
    Immunophenotype
    Cytogenetic and Molecular Studies
    Variants of Follicular Lymphoma
    Differential Diagnosis
    Additional Resources
    35. Mantle Cell Lymphoma
    Morphology
    Immunophenotype
    Cytogenetic and Molecular Studies
    Indolent Variant of MCL
    Differential Diagnosis
    Additional Resources
    36. Diffuse Large B-Cell Lymphoma
    Morphology and Laboratory Findings
    Immunophenotype
    Molecular and Cytogenetic Studies
    Differential Diagnosis
    Additional Resources
    37. Diffuse Large B-Cell Lymphoma Subtypes
    T-Cell/Histiocyte-Rich Large B-Cell Lymphoma
    EBV+ Diffuse Large B-Cell Lymphoma of the Elderly
    Primary DLBCL of the CNS
    Additional Resources
    38. Other Lymphomas of Large B Cells
    Primary Mediastinal (Thymic) Large B-Cell Lymphoma
    Intravascular Large B-Cell Lymphoma
    Diffuse Large B-Cell Lymphoma Associated with Chronic Inflammation
    Lymphomatoid Granulomatosis
    ALK-Positive Large B-Cell Lymphoma
    Primary Effusion Lymphoma
    Plasmablastic Lymphoma
    Large B-Cell Lymphoma Arising in HHV8-Associated Multicentric Castleman Disease
    HHV8- and EBV-Associated Germinotropic Lymphoproliferative Disorder
    B-Cell Lymphoma, Unclassifiable, with Features Intermediate between DLBCL and Classical Hodgkin Lymphoma
    Additional Resources
    39. Burkitt Lymphoma
    Burkitt Lymphoma
    B-Cell Lymphoma, Unclassifiable, with Features Intermediate Between Diffuse Large B-Cell Lymphoma and Burkitt Lymphoma
    Additional Resources
    40. Primary Cutaneous B-Cell Lymphomas
    Primary Cutaneous Follicle Center Lymphoma
    Primary Cutaneous Marginal Zone Lymphoma
    Primary Cutaneous Diffuse Large B-Cell Lymphoma–Leg Type
    Plasmacytoma
    Additional Resources
    41. Plasma Cell Neoplasms
    Monoclonal Gammopathy of Undetermined Significance
    Plasma Cell Myeloma
    Osteosclerotic Myeloma
    Plasmacytoma
    Deposition Diseases
    Additional Resources
    42. Mature T- and NK-Cell Neoplasms—Overview
    T-Cells
    NK-cells
    Classification
    Additional Resources
    43. Large Granular Lymphocytic Neoplasms and Related Disorders
    T-Cell Large Granular Lymphocytic Leukemia
    Chronic Lymphoproliferative Disorder of NK Cells
    Aggressive NK-Cell Leukemia
    Extranodal NK/T-Cell Lymphoma, Nasal Type
    EBV-Associated T/NK-Cell Lymphoproliferative Disorder of Children and Young Adults
    Differential Diagnosis
    Additional Resources
    44. T-Cell Prolymphocytic Leukemia
    Morphology
    Immunophenotype
    Cytogenetic and Molecular Studies
    Differential Diagnosis
    Additional Resources
    45. Adult T-Cell Leukemia/Lymphoma
    Morphology
    Immunophenotype
    Molecular and Cytogenetic Studies
    Differential Diagnosis
    Additional Resources
    46. Hepatosplenic T-Cell Lymphoma
    Morphology
    Immunophenotype
    Molecular and Cytogenetic Studies
    Differential Diagnosis
    Additional Resources
    47. Enteropathy-Associated T-Cell Lymphoma
    Morphology
    Immunophenotype
    Molecular and Cytogenetic Studies
    Differential Diagnosis
    Additional Resources
    48. Mycosis Fungoides and Sézary Syndrome
    Mycosis Fungoides
    Sézary Syndrome
    Differential Diagnosis
    Additional Resources
    49. Other Primary Cutaneous T-Cell Lymphoproliferative Disorders
    Primary Cutaneous CD30-Positive T-Cell Lymphoproliferative Disorders
    Subcutaneous Panniculitis-Like T-Cell Lymphoma
    Cutaneous γδ T-Cell Lymphoma
    Primary Cutaneous Aggressive Epidermotropic CD8+ Cytotoxic T-Cell Lymphoma
    Primary Cutaneous CD4+ Small/Medium T-Cell Lymphoma
    Epstein–Barr Virus-Associated Hydroa Vacciniforme-Like Cutaneous Lymphoma of Childhood
    Differential Diagnosis
    Additional Resources
    50. Angioimmunoblastic T-Cell Lymphoma
    Morphology and Laboratory Findings
    Immunophenotype
    Molecular and Cytogenetic Studies
    Differential Diagnosis
    Additional Resources
    51. Anaplastic Large Cell Lymphomas
    Anaplastic Large Cell Lymphoma, ALK-Positive
    Anaplastic Large Cell Lymphoma, ALK-Negative
    Borderline Cases
    Differential Diagnosis
    Additional Resources
    52. Peripheral T-Cell Lymphoma, Not Otherwise Specified
    Morphology
    Immunophenotype
    Molecular and Cytogenetic Studies
    Differential Diagnosis
    Additional Resources
    53. Nodular Lymphocyte Predominant Hodgkin Lymphoma
    Overview of Hodgkin Lymphoma
    Nodular Lymphocyte Predominant Hodgkin Lymphoma
    Additional Resources
    54. Classical Hodgkin Lymphoma
    Nodular Sclerosis Classical Hodgkin Lymphoma
    Mixed Cellularity Classical Hodgkin Lymphoma
    Lymphocyte-Rich Classical Hodgkin Lymphoma
    Lymphocyte-Depleted Classical Hodgkin Lymphoma
    Differential Diagnosis
    Additional Resources
    55. Immunodeficiency Disorders
    Primary Immunodeficiency Syndromes
    Human Immunodeficiency Virus/Acquired Immunodeficiency Syndrome
    Idiopathic CD4+ T-Lymphocytopenia
    Additional Resources
    56. Iatrogenic Immunodeficiency-Associated Lymphoproliferative Disorders
    Post-Transplant Lymphoproliferative Disorders
    Other Iatrogenic Immunodeficiency-Associated Lymphoproliferative Disorders
    Additional Resources
    57. Lymphocytopenia and Lymphocytosis
    Lymphocytopenia
    Lymphocytosis
    Additional Resources
    58. Histiocytic Disorders
    Gaucher Disease
    Niemann–Pick Disease
    Chédiak–Higashi Syndrome
    Monocytopenia and Monocytosis
    Reactive Histiocytic Proliferations
    Hemophagocytic Lymphohistiocytosis
    Histiocytic Sarcoma
    Additional Resources
    59. Disorders of Dendritic Cells
    Langerhans Cell Histiocytosis
    Langerhans Cell Sarcoma
    Blastic Plasmacytoid Dendritic Cell Neoplasm
    Interdigitating Dendritic Cell Sarcoma
    Follicular Dendritic Cell Sarcoma
    Additional Resources
    60. Granulocytic Disorders
    Morphologic Abnormalities
    Functional Abnormalities
    Neutropenia
    Neutrophilia
    Eosinophilia
    Basophilia
    Additional Resources
    61. Disorders of Red Blood Cells—Anemias
    Pure Red Cell Aplasia
    Congenital Dyserythropoietic Anemias
    Macrocytic Anemias
    Microcytic Anemias
    Sickle Cell Disease
    Other Hemoglobinopathies
    Erythrocyte Membrane Skeleton Defects
    Hemolytic Anemia Secondary to Erythrocyte Enzyme Deficiencies
    Immune-Mediated Hemolytic Anemia
    Acquired Non-Immune Hemolytic Anemias
    Other Types of Anemia
    Additional Resources
    62. Disorders of Megakaryocytes and Platelets
    Megakaryocytic Hypoplasia
    Megakaryocytosis
    Thrombocytopenia
    Qualitative Disorders of Platelets and Megakaryocytes
    Disorders of Platelet Secretion and Granule Deficiencies
    Acquired Platelet Disorders
    Additional Resources
    63. Post-Therapy Changes
    Changes Associated with Hematopoietic Stem Cell Transplantation
    Post Chemotherapy and Irradiation Changes
    Cytokine-Associated Bone Marrow Changes
    Changes Associated with Application of Monoclonal Antibodies
    Changes Associated with Imatinib Mesylate (Gleevec) Therapy
    Minimal Residual Disease
    Additional Resources
    Index

Product details

  • No. of pages: 756
  • Language: English
  • Copyright: © Academic Press 2012
  • Published: December 21, 2012
  • Imprint: Academic Press
  • eBook ISBN: 9780123851840

About the Author

Faramarz Naeim

Dr. Faramarz Naeim is Professor Emeritus of Pathology, David Geffen School of Medicine, UCLA. He graduated from Tehran University School of Medicine and received his training in Pathology at Mallory Institute of Pathology, Boston City Hospital and Department of Pathology at UCLA School of Medicine. He has provided clinical services as a hematopathologist for 43 years, 30 years at UCLA, Department of Pathology and Laboratory Medicine, and 13 years at VA Greater Los Angeles Healthcare System, Department of Pathology and Laboratory Medicine. Dr. Naeim has published several books and book chapters in hematopathology and numerous articles in peer review journals.

Affiliations and Expertise

Professor Emeritus, Department of Pathology, David Geffen UCLA School of Medicine, Hematopathologist, Department of Pathology and Laboratory Medicine, VA Greater Los Angeles Healthcare System, Los Angeles, California

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