Asthma and COPD

2nd Edition

Basic Mechanisms and Clinical Management

Print ISBN: 9780123740014
eBook ISBN: 9780080920603
Imprint: Academic Press
Published Date: 30th October 2008
Page Count: 896

Institutional Access


The Second Edition of Asthma and COPD: Basic Mechanisms and Clinical Management continues to provide a unique and authoritative comparison of asthma and COPD. Written and edited by the world's leading experts, it continues to be a comprehensive review of the most recent understanding of the basic mechanisms of both conditions, specifically comparing their etiology, pathogenesis, and treatments.

Key Features

  • Each chapter considers Asthma and COPD in side-by-side contrast and comparison – not in isolation - in the context of mechanism, triggers, assessments, therapies, and clinical management
  • Presents the latest and most comprehensive understandings of the mechanisms of inflammation in both Asthma and COPD
  • Most extensive reference to primary literature on both Asthma and COPD in one source.
  • Easy-to-read summaries of the latest advances alongside clear illustrations


Cell biologists, immunologists, pharmacologists and physicians working in pulmonary research in academia or the pharmaceutical industry

Table of Contents

1 Definitions, Epidemiology and Genetics of Asthma and COPD 2 Epidemiology 3 Natural History 4 Genetics of Asthma and COPD 5 Pulmonary Physiology 6 Airway Pathology
7 Airway Remodeling 8 Animal Models 9 Mast Cells and Basophils 10 Dentritic Cells 11 Macrophages 12 Eosinophils 13 Lymphocytes 14 Neutrophils 15 Fibroblasts 16 Epithelial Cells 17 Mucus and Mucin-Secreting Cells 18 Airway Smooth Muscle 19 Tracheobronchial Circulation 20 Pulmonary Vessels 21 Adhesion Molecules 22 Extracellular Matrix 23 Prostanoids 24 Leukotrienes and Lipoxins 25 Reactive Oxygen Species 26 Chemokines 27 Cytokines 28 Matrix Degrading Proteinases 29 Growth Factors, 30 Nitric Oxide 31 Transcription Factors 32 Neural and Humoral Control 33 Pathophysiology of Asthma 34 Pathogenesis of COPD 35 Allergens 36 Occupational Agents 37 Infections 38 Exercise as a Stimulus 39 Atmospheric Pollutants 40 Drugs 41 Diagnosis 42 Non-invasive Assessment of Airway Inflammation 43 Imaging 44 Systemic Manifestations 45 Cardiovascular Effects 46 Allergen Avoidance 47 Smoking Cessation 48 â2-adrenoceptor Agonists 49 Anticholinergic Bronchodilators 50 Theophylline 51 Corticosteroids 52 Mediator Antagonists 53 Antibiotics 54 Long-term Oxygen Therapy 55 Immunomodulators 56 Pulmonary Vasodilators 57


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© Academic Press 2009
Academic Press
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"...textbooks, such as the one discussed here, are all essential in shaping a necessary way forward to fight chronic respiratory diseases worldwide...At first it was a surprise to see that this impressive textbook covered both asthma and chronic obstructive pulmonary disease (COPD) in one volume. Asthma and COPD: Basic Mechanisms and Clinical Management is edited and written by prominent individuals who have done everything possible in the past to convey the message that asthma and COPD are two different diseases: that they are characterised by different risk factors; have a different pathophysiology; are characterised by clinical phenotypes that are distinctly different; require different therapeutic strategies; and probably pose very different challenges to the health-care system. Yet in this textbook they now provide a truly novel approach towards our understanding and perception of asthma and COPD...the combined approach set out in this book towards asthma and COPD is not so much the Dutch hypothesis revisited, rather it is a more than sensible approach to understanding the nature and the challenges of chronic respiratory diseases in general.
Asthma and COPD provides a superb synthesis of the most up-to-date knowledge on obstructive airways diseases by leading experts in the field...The description of basic mechanisms is a particularly strong feature, but the reader also finds excellent chapters on the pathogenic mechanisms of asthma and COPD, a description of risk factors and triggers, and a clinically useful description of the clinical assessment of these frequent conditions...this textbook is a joy to browse through and to read; it is very well illustrated, and the tabulated material is truly educational...I hope that this book will become one of the major reference sources for information on asthma and COPD and that it might have the potential to serve a much wider medical community than respiratory textbooks usually do."
--Klaus F. Rabe, The Lancet