Asthma and COPD - 2nd Edition - ISBN: 9780123740014, 9780080920603

Asthma and COPD

2nd Edition

Basic Mechanisms and Clinical Management

Editors: Peter Barnes Jeffrey Drazen Stephen Rennard Neil Thomson
eBook ISBN: 9780080920603
Hardcover ISBN: 9780123740014
Imprint: Academic Press
Published Date: 30th October 2008
Page Count: 896
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The Second Edition of Asthma and COPD: Basic Mechanisms and Clinical Management continues to provide a unique and authoritative comparison of asthma and COPD. Written and edited by the world's leading experts, it continues to be a comprehensive review of the most recent understanding of the basic mechanisms of both conditions, specifically comparing their etiology, pathogenesis, and treatments.

Key Features

  • Each chapter considers Asthma and COPD in side-by-side contrast and comparison – not in isolation - in the context of mechanism, triggers, assessments, therapies, and clinical management
  • Presents the latest and most comprehensive understandings of the mechanisms of inflammation in both Asthma and COPD
  • Most extensive reference to primary literature on both Asthma and COPD in one source.
  • Easy-to-read summaries of the latest advances alongside clear illustrations


Cell biologists, immunologists, pharmacologists and physicians working in pulmonary research in academia or the pharmaceutical industry

Table of Contents

1 Definitions, Epidemiology and Genetics of Asthma and COPD 2 Epidemiology 3 Natural History 4 Genetics of Asthma and COPD 5 Pulmonary Physiology 6 Airway Pathology
7 Airway Remodeling 8 Animal Models 9 Mast Cells and Basophils 10 Dentritic Cells 11 Macrophages 12 Eosinophils 13 Lymphocytes 14 Neutrophils 15 Fibroblasts 16 Epithelial Cells 17 Mucus and Mucin-Secreting Cells 18 Airway Smooth Muscle 19 Tracheobronchial Circulation 20 Pulmonary Vessels 21 Adhesion Molecules 22 Extracellular Matrix 23 Prostanoids 24 Leukotrienes and Lipoxins 25 Reactive Oxygen Species 26 Chemokines 27 Cytokines 28 Matrix Degrading Proteinases 29 Growth Factors, 30 Nitric Oxide 31 Transcription Factors 32 Neural and Humoral Control 33 Pathophysiology of Asthma 34 Pathogenesis of COPD 35 Allergens 36 Occupational Agents 37 Infections 38 Exercise as a Stimulus 39 Atmospheric Pollutants 40 Drugs 41 Diagnosis 42 Non-invasive Assessment of Airway Inflammation 43 Imaging 44 Systemic Manifestations 45 Cardiovascular Effects 46 Allergen Avoidance 47 Smoking Cessation 48 â2-adrenoceptor Agonists 49 Anticholinergic Bronchodilators 50 Theophylline 51 Corticosteroids 52 Mediator Antagonists 53 Antibiotics 54 Long-term Oxygen Therapy 55 Immunomodulators 56 Pulmonary Vasodilators 57 Ventilator Support 58 Pulmonary Rehabilitation 59 Surgery and Other Mechanical Interventions 60 Other Therapies 61 Future Therapies 62 Health Economics 63 Management of Chronic Asthma in Adults 64 Asthma Exacerbations 65 Childhood Asthma 66 Treatment for Stable COPD 67 Acute Exacerbations of COPD 68 Education and Self-Management


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About the Editor

Peter Barnes

Peter Barnes is Professor of Thoracic Medicine at the National Heart and Lung Institute, Head of Respiratory Medicine at Imperial College and Honorary Consultant Physician at Royal Brompton Hospital, London. He qualified at Cambridge and Oxford Universities was appointed to his present post in 1987. He has published over 1000 peer-review papers on asthma, COPD and related topics and has edited over 40 books. He is also amongst the top 50 most highly cited researchers in the world and has been the most highly cited clinical scientist in the UK and the most highly cited respiratory researcher in the world over the last 20 years. He was elected a Fellow of the Royal Society in 2007, the first respiratory researcher for over 150 years. He is currently a member of the Scientific Committee of the WHO/NIH global guidelines on asthma (GINA) and COPD (GOLD). He also serves on the Editorial Board of over 30 journals and is currently an Associate Editor of Chest and respiratory Editor of PLoS Medicine. He has given several prestigious lectures, including the Amberson Lecture at the American Thoracic Society and the Sadoul Lecture at the European Respiratory Society.

Affiliations and Expertise

Head of Respiratory Medicine, Imperial College, London, UK, Airway Disease Section, National Heart and Lung Institute

Jeffrey Drazen

Jeffrey M. Drazen, MD, was born in St. Louis, Missouri. He graduated from Tufts University with a major in physics, and from Harvard Medical School. He served his medical internship and residency at Peter Bent Brigham Hospital in Boston and was a clinical fellow and research fellow at Harvard Medical School and Harvard School of Public Health. Thereafter, he joined the Pulmonary Divisions of the Harvard hospitals and served for many years as chief of the combined Pulmonary Divisions at Beth Israel and Brigham and Women’s Hospitals.

Currently, he is a Senior Physician at the Brigham and Women’s Hospital, and the Distinguished Parker B. Francis Professor of Medicine at Harvard Medical School, as well as Professor of Physiology, Harvard School of Public Health and adjunct Professor of Medicine at Boston University School of Medicine.

He has served on the NIH Respiratory and Applied Physiology Study Section, the NIH Pulmonary Disease Advisory Council, the NIH Lung Biology and Pathology Study Section, and the NHLBI Advisory Council.

Through his research, he defined the role of novel endogenous chemical agents in asthma. This led to four new licensed pharmaceuticals for asthma used in the treatment of millions of people worldwide. He has published nearly 500 papers and edited 6 books.

He has been a member of the editorial boards of many prestigious journals, including: the Journal of Applied Physiology, American Journal of Physiology, Pulmonary Pharmacology, Experimental Lung Research, Journal of Clinical Investigation, American Journal of Respiratory Cell and Molecular Biology, and the American Journal of Medicine. In addition, he has been associate editor of the Journal of Clinical Investigation and the American Review of Respiratory Disease.

In 2000, he assumed the post of editor-in-chief of the New England Journal of Medicine. During his tenure, the Journal has published major papers advancing the science of medicine.

Affiliations and Expertise

Brigham and Women's Hospital, Boston, MA, USA

Stephen Rennard

Affiliations and Expertise

University of Nebraska Medical Center, Omaha, USA

Neil Thomson

Neil Thomson is Professor of Respiratory Medicine at the University of Glasgow, Head of Respiratory Medicine within the Division of Immunology, Infection & Inflammation and Honorary Consultant at Gartnavel General Hospital, Glasgow. He graduated from the University of Glasgow and undertook postgraduate training in Glasgow, London and McMaster University, Canada. He is a former member of the Committee for Safety of Medicine and former Chair of the Scientific Committee of the British Lung Foundation. He has co-edited several textbooks on asthma and COPD and published over 150 peer-reviewed papers on asthma. His current research interests include corticosteroid insensitivity in smokers with asthma, biomarkers in asthma and COPD and assessment of novel treatments for asthma.

Affiliations and Expertise

Western Infirmary, Glasgow, Scotland


"...textbooks, such as the one discussed here, are all essential in shaping a necessary way forward to fight chronic respiratory diseases worldwide...At first it was a surprise to see that this impressive textbook covered both asthma and chronic obstructive pulmonary disease (COPD) in one volume. Asthma and COPD: Basic Mechanisms and Clinical Management is edited and written by prominent individuals who have done everything possible in the past to convey the message that asthma and COPD are two different diseases: that they are characterised by different risk factors; have a different pathophysiology; are characterised by clinical phenotypes that are distinctly different; require different therapeutic strategies; and probably pose very different challenges to the health-care system. Yet in this textbook they now provide a truly novel approach towards our understanding and perception of asthma and COPD...the combined approach set out in this book towards asthma and COPD is not so much the Dutch hypothesis revisited, rather it is a more than sensible approach to understanding the nature and the challenges of chronic respiratory diseases in general.
Asthma and COPD provides a superb synthesis of the most up-to-date knowledge on obstructive airways diseases by leading experts in the field...The description of basic mechanisms is a particularly strong feature, but the reader also finds excellent chapters on the pathogenic mechanisms of asthma and COPD, a description of risk factors and triggers, and a clinically useful description of the clinical assessment of these frequent conditions...this textbook is a joy to browse through and to read; it is very well illustrated, and the tabulated material is truly educational...I hope that this book will become one of the major reference sources for information on asthma and COPD and that it might have the potential to serve a much wider medical community than respiratory textbooks usually do."
--Klaus F. Rabe, The Lancet

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