Asthma and COPD

Asthma and COPD

Basic Mechanisms and Clinical Management

2nd Edition - October 30, 2008

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  • Editors: Peter Barnes, Jeffrey Drazen, Stephen Rennard, Neil Thomson
  • Hardcover ISBN: 9780123740014

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Asthma and COPD: Basic Mechanisms and Clinical Management, Second Edition continues to provide a unique and authoritative comparison of asthma and COPD. Written and edited by the world's leading experts, it continues to be a comprehensive review of the most recent understanding of the basic mechanisms of both conditions, specifically comparing their etiology, pathogenesis, and treatments.

Key Features

  • Each chapter considers Asthma and COPD in side-by-side contrast and comparison – not in isolation - in the context of mechanism, triggers, assessments, therapies, and clinical management
  • Presents the latest and most comprehensive understandings of the mechanisms of inflammation in both Asthma and COPD
  • Most extensive reference to primary literature on both Asthma and COPD in one source.
  • Easy-to-read summaries of the latest advances alongside clear illustrations


Cell biologists, immunologists, pharmacologists and physicians working in pulmonary research in academia or the pharmaceutical industry

Table of Contents

  • 1. Definitions, Epidemiology and Genetics of Asthma and COPD
    2. Epidemiology
    3. Natural History
    4. Genetics of Asthma and COPD
    5. Pulmonary Physiology
    6. Airway Pathology
    7. Airway Remodeling
    8. Animal Models
    9. Mast Cells and Basophils
    10. Dentritic Cells
    11. Macrophages
    12. Eosinophils
    13. Lymphocytes
    14. Neutrophils
    15. Fibroblasts
    16. Epithelial Cells
    17. Mucus and Mucin-Secreting Cells
    18. Airway Smooth Muscle
    19. Tracheobronchial Circulation
    20. Pulmonary Vessels
    21. Adhesion Molecules
    22. Extracellular Matrix
    23. Prostanoids
    24. Leukotrienes and Lipoxins
    25. Reactive Oxygen Species
    26. Chemokines
    27. Cytokines
    28. Matrix Degrading Proteinases
    29. Growth Factors,
    30. Nitric Oxide
    31. Transcription Factors
    32. Neural and Humoral Control
    33. Pathophysiology of Asthma
    34. Pathogenesis of COPD
    35. Allergens
    36. Occupational Agents
    37. Infections
    38. Exercise as a Stimulus
    39. Atmospheric Pollutants
    40. Drugs
    41. Diagnosis
    42. Non-invasive Assessment of Airway Inflammation
    43. Imaging
    44. Systemic Manifestations
    45. Cardiovascular Effects
    46. Allergen Avoidance
    47. Smoking Cessation
    48. â2-adrenoceptor Agonists
    49. Anticholinergic Bronchodilators
    50. Theophylline
    51. Corticosteroids
    52. Mediator Antagonists
    53. Antibiotics
    54. Long-term Oxygen Therapy
    55. Immunomodulators
    56. Pulmonary Vasodilators
    57. Ventilator Support
    58. Pulmonary Rehabilitation
    59. Surgery and Other Mechanical Interventions
    60. Other Therapies
    61. Future Therapies
    62. Health Economics
    63. Management of Chronic Asthma in Adults
    64. Asthma Exacerbations
    65. Childhood Asthma
    66. Treatment for Stable COPD
    67. Acute Exacerbations of COPD
    68. Education and Self-Management

Product details

  • No. of pages: 896
  • Language: English
  • Copyright: © Academic Press 2008
  • Published: October 30, 2008
  • Imprint: Academic Press
  • Hardcover ISBN: 9780123740014

About the Editors

Peter Barnes

Peter Barnes is Professor of Thoracic Medicine at the National Heart and Lung Institute, Head of Respiratory Medicine at Imperial College and Honorary Consultant Physician at Royal Brompton Hospital, London. He qualified at Cambridge and Oxford Universities was appointed to his present post in 1987. He has published over 1000 peer-review papers on asthma, COPD and related topics and has edited over 40 books. He is also amongst the top 50 most highly cited researchers in the world and has been the most highly cited clinical scientist in the UK and the most highly cited respiratory researcher in the world over the last 20 years. He was elected a Fellow of the Royal Society in 2007, the first respiratory researcher for over 150 years. He is currently a member of the Scientific Committee of the WHO/NIH global guidelines on asthma (GINA) and COPD (GOLD). He also serves on the Editorial Board of over 30 journals and is currently an Associate Editor of Chest and respiratory Editor of PLoS Medicine. He has given several prestigious lectures, including the Amberson Lecture at the American Thoracic Society and the Sadoul Lecture at the European Respiratory Society.

Affiliations and Expertise

Head of Respiratory Medicine, Imperial College, London, UK, Airway Disease Section, National Heart and Lung Institute

Jeffrey Drazen

Jeffrey M. Drazen, MD, was born in St. Louis, Missouri. He graduated from Tufts University with a major in physics, and from Harvard Medical School. He served his medical internship and residency at Peter Bent Brigham Hospital in Boston and was a clinical fellow and research fellow at Harvard Medical School and Harvard School of Public Health. Thereafter, he joined the Pulmonary Divisions of the Harvard hospitals and served for many years as chief of the combined Pulmonary Divisions at Beth Israel and Brigham and Women’s Hospitals.

Currently, he is a Senior Physician at the Brigham and Women’s Hospital, and the Distinguished Parker B. Francis Professor of Medicine at Harvard Medical School, as well as Professor of Physiology, Harvard School of Public Health and adjunct Professor of Medicine at Boston University School of Medicine.

He has served on the NIH Respiratory and Applied Physiology Study Section, the NIH Pulmonary Disease Advisory Council, the NIH Lung Biology and Pathology Study Section, and the NHLBI Advisory Council.

Through his research, he defined the role of novel endogenous chemical agents in asthma. This led to four new licensed pharmaceuticals for asthma used in the treatment of millions of people worldwide. He has published nearly 500 papers and edited 6 books.

He has been a member of the editorial boards of many prestigious journals, including: the Journal of Applied Physiology, American Journal of Physiology, Pulmonary Pharmacology, Experimental Lung Research, Journal of Clinical Investigation, American Journal of Respiratory Cell and Molecular Biology, and the American Journal of Medicine. In addition, he has been associate editor of the Journal of Clinical Investigation and the American Review of Respiratory Disease.

In 2000, he assumed the post of editor-in-chief of the New England Journal of Medicine. During his tenure, the Journal has published major papers advancing the science of medicine.

Affiliations and Expertise

Brigham and Women's Hospital, Boston, MA, USA

Stephen Rennard

Affiliations and Expertise

University of Nebraska Medical Center, Omaha, USA

Neil Thomson

Neil Thomson is Professor of Respiratory Medicine at the University of Glasgow, Head of Respiratory Medicine within the Division of Immunology, Infection & Inflammation and Honorary Consultant at Gartnavel General Hospital, Glasgow. He graduated from the University of Glasgow and undertook postgraduate training in Glasgow, London and McMaster University, Canada. He is a former member of the Committee for Safety of Medicine and former Chair of the Scientific Committee of the British Lung Foundation. He has co-edited several textbooks on asthma and COPD and published over 150 peer-reviewed papers on asthma. His current research interests include corticosteroid insensitivity in smokers with asthma, biomarkers in asthma and COPD and assessment of novel treatments for asthma.

Affiliations and Expertise

Western Infirmary, Glasgow, Scotland

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