Table of Contents

Contents Foreword Contributors Preface Dedication Part I: Definitions, Epidemiology, and Genetics of Asthma and COPD 1 Definitions 2 Epidemiology 3 Natural History 4 Genetics Part II: Physiology and Pathology of Asthma and COPD 5 Pulmonary Physiology 6 Airway Pathology 7 Airway Remodeling 8 Animal Models Part III: Inflammatory Cells and Extracellular Matrix 9 Mast Cells and Basophils 10 Macrophages 11 Eosinophils 12 Lymphocytes 13 Neutrophils 14 Fibroblasts 15 Epithelial Cells 16 Mucus and Mucin-Secreting Cells 17 Airway Smooth Muscle 18 Tracheobronchial Circulation 19 Pulmonary Vessels 20 Plasma Exudation 21 Cell Adhesion Molecules, 22 Extracellular Matrix Part IV: Inflammatory Mediators and Pathways 23 Prostanoids 24 Leukotrienes 25 Kinins 26 Reactive Oxygen Species 27 Chemokines 28 Cytokines 29 Matrix Degrading Proteinases 30 Growth Factors 31 Other Mediators of Airway Disease 32 Nitric Oxide 33 Transcription Factors 34 Neural and Humoral Control Part V: Pathogenic Mechanisms in Asthma and COPD 35 Pathophysiology of Asthma 36 Pathogenesis of COPD Part VI: Triggers of Asthma and COPD 37 Allergens 38 Occupational Agents 39 Infections 40 Exercise as a Trigger 41 Atmospheric Pollutants 42 Drugs Part VII: Clinical Assessment of Asthma and COPD 43 Diagnosis 44 Non-invasive Assessment of Airway Inflammation 45 Imaging 46 Assessment of Disability Part VIII: Therapies for Asthma and COPD 47 Allergen Avoidance 48 Smoking Cessation 49 b2-adrenoceptor Agonists 50 Anticholinergic Bronchodilators 51 Theophylline 52 Corticosteroids 53 Mediator Antagonists 54 Antibiotics 55 Long-term Oxygen Therapy 56 Immunomodulators 57 Pulmonary

Details

No. of pages:
780
Language:
English
Copyright:
© 2002
Published:
Imprint:
Academic Press
Print ISBN:
9780120790289
Electronic ISBN:
9780080488356

About the authors

Peter Barnes

Peter Barnes is Professor of Thoracic Medicine at the National Heart and Lung Institute, Head of Respiratory Medicine at Imperial College and Honorary Consultant Physician at Royal Brompton Hospital, London. He qualified at Cambridge and Oxford Universities was appointed to his present post in 1987. He has published over 1000 peer-review papers on asthma, COPD and related topics and has edited over 40 books. He is also amongst the top 50 most highly cited researchers in the world and has been the most highly cited clinical scientist in the UK and the most highly cited respiratory researcher in the world over the last 20 years. He was elected a Fellow of the Royal Society in 2007, the first respiratory researcher for over 150 years. He is currently a member of the Scientific Committee of the WHO/NIH global guidelines on asthma (GINA) and COPD (GOLD). He also serves on the Editorial Board of over 30 journals and is currently an Associate Editor of Chest and respiratory Editor of PLoS Medicine. He has given several prestigious lectures, including the Amberson Lecture at the American Thoracic Society and the Sadoul Lecture at the European Respiratory Society.

Jeffrey Drazen

Jeffrey M. Drazen, MD, was born in St. Louis, Missouri. He graduated from Tufts University with a major in physics, and from Harvard Medical School. He served his medical internship and residency at Peter Bent Brigham Hospital in Boston and was a clinical fellow and research fellow at Harvard Medical School and Harvard School of Public Health. Thereafter, he joined the Pulmonary Divisions of the Harvard hospitals and served for many years as chief of the combined Pulmonary Divisions at Beth Israel and Brigham and Women’s Hospitals. Currently, he is a Senior Physician at the Brigham and Women’s Hospital, and the Distinguished Parker B. Francis Professor of Medicine at Harvard Medical School, as well as Professor of Physiology, Harvard School of Public Health and adjunct Professor of Medicine at Boston University School of Medicine. He has served on the NIH Respiratory and Applied Physiology Study Section, the NIH Pulmonary Disease Advisory Council, the NIH Lung Biology and Pathology Study Section, and the NHLBI Advisory Council. Through his research, he defined the role of novel endogenous chemical agents in asthma. This led to four new licensed pharmaceuticals for asthma used in the treatment of millions of people worldwide. He has published nearly 500 papers and edited 6 books. He has been a member of the editorial boards of many prestigious journals, including: the Journal of Applied Physiology, American Journal of Physiology, Pulmonary Pharmacology, Experimental Lung Research, Journal of Clinical Investigation, American Journal of Respiratory Cell and Molecular Biology, and the American Journal of Medicine. In addition, he has been associate editor of the Journal of Clinical Investigation and the American Review of Respiratory Disease. In 2000, he assumed the post of editor-in-chief of the New England Journal of Medicine. During his tenure, the Journal has published major papers advancing the science of medicine, including the first description

Neil Thomson

Neil Thomson is Professor of Respiratory Medicine at the University of Glasgow, Head of Respiratory Medicine within the Division of Immunology, Infection & Inflammation and Honorary Consultant at Gartnavel General Hospital, Glasgow. He graduated from the University of Glasgow and undertook postgraduate training in Glasgow, London and McMaster University, Canada. He is a former member of the Committee for Safety of Medicine and former Chair of the Scientific Committee of the British Lung Foundation. He has co-edited several textbooks on asthma and COPD and published over 150 peer-reviewed papers on asthma. His current research interests include corticosteroid insensitivity in smokers with asthma, biomarkers in asthma and COPD and assessment of novel treatments for asthma.