Applied Dermatotoxicology

Applied Dermatotoxicology

Clinical Aspects

1st Edition - May 15, 2014

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  • Authors: Howard Maibach, Golara Honari
  • Paperback ISBN: 9780124201309
  • eBook ISBN: 9780124201996

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Applied Dermatotoxicology: Clinical Aspects provides concise, systematic, and state-of-the-art information on the toxicological effects of substances on skin, and recent advances in dermal toxicity testing. This book specifically addresses the clinical presentations borne out of exposure to a variety of chemicals. It begins with an overview of skin biology to provide toxicologists with a basic understanding of its anatomy and physiology. Next it presents a variety of dermatotoxicological effects, as well at the toxic agents that cause them, with color photographs to illustrate these effects. Applied Dermatotoxicology: Clinical Aspects is an essential reference for toxicologists in industry, and for those medical professionals who encounter cases of dermal exposure to toxic agents.

Key Features

  • A concise, yet inclusive review of effects of chemical exposure
  • Includes background on basic skin biology
  • Provides vital clinical reference for toxicologists in non-clinical settings


Applied Dermatotoxicology: Clinical Aspects is intended for toxicologists, and for those medical professionals who encounter cases of dermal exposure to toxic agents

Table of Contents

    • List of Contributors
    • Preface
    • Chapter 1. Skin Structure and Function
      • Introduction
      • Structure and Function
      • Skin Appendages
      • Skin a Route of Entry
      • Measuring Skin
      • References
    • Chapter 2. Irritant Contact Dermatitis: Clinical Aspects
      • Introduction
      • Clinical Manifestations of Irritant Dermatitis
      • Special Clinical Forms of Irritant Dermatitis
      • Summary
      • Toxicology
      • References
      • References
    • Chapter 3. Photoirritation (Phototoxicity): Clinical Aspects
      • Introduction
      • Basic Principles of Photobiology
      • Mechanisms of Phototoxic Reactions
      • Clinical Presentations
      • Main Topical and Systemic Photosensitizers
      • Summary
      • Phototoxicity Testing
      • References
      • References
    • Chapter 4. Allergic Contact Dermatitis: Clinical Aspects
      • Introduction
      • ACD Syndrome
      • Stage 1 of ACDS
      • Stage 2 of ACDS
      • Stage 3 of ACDS
      • ICD Versus ACD: Clinical Aspects
      • Hand Eczema (Hand Dermatitis) and ACD
      • Photoallergic Contact Dermatitis
      • ACD: The Patch Test, First-Line Diagnostic Tool
      • The Series of Patch Test Allergens
      • The Panoply of Additional Diagnostic Tools
      • Testing End-Products with Unknown Components
      • Treatment
      • Toxicology of Skin Sensitization
      • References
      • References
    • Chapter 5. Photoallergic Contact Dermatitis: Clinical Aspects
      • Definition and Background
      • History
      • Epidemiology
      • Mechanisms and Pathogenesis
      • Clinical Presentation of Photoallergic Contact Dermatitis
      • Investigation
      • Photopatch Testing Technique
      • Test Procedure
      • Test Material
      • Reading and Interpretation of Results
      • Current Common Topical Photoallergens
      • Regulatory Aspects
      • Toxicology of Photoallergy
      • References
      • References
    • Chapter 6. Contact Urticaria Syndrome: Clinical Aspects
      • Introduction
      • Clinical Features
      • Mechanisms and Common Causes
      • Differential Diagnosis
      • Diagnosis and Testing
      • Treatment and Prevention
      • Discussion
      • Toxicology of Contact Urticaria Syndrome
      • References
      • References

Product details

  • No. of pages: 150
  • Language: English
  • Copyright: © Academic Press 2014
  • Published: May 15, 2014
  • Imprint: Academic Press
  • Paperback ISBN: 9780124201309
  • eBook ISBN: 9780124201996

About the Authors

Howard Maibach

Howard Maibach is a Professor at the Department of Dermatology at UCSF, USA. He is an expert in contact and occupational dermatitis and sees patients at the Environmental Dermatosis Clinic, which is part of the Dermatology Clinic. His specialty is dermatotoxicology, or skin exposure toxicity; allergies and skin disorders; and dermatopharmacology or the study of medications for skin disorders. Maibach has been on the editorial board of more than 30 scientific journals and is a member of 19 professional societies including the American Academy of Dermatology, San Francisco Dermatological Society, and the Internal Commission on Occupation Health. His current research programs include defining the chemical-biologic faces of irritant dermatitis and the study of percutaneous penetration. When Dr Maibach is not in the lab conducting research or in the classroom teaching, he is seeing patients at the Environmental Dermatoses Clinic (of the Dermatology Clinic), mostly providing second opinions on allergic contact dermatitis.

Affiliations and Expertise

Professor of Dermatology, University of California, San Francisco, USA

Golara Honari

Golara Honari, MD, FAAD, Consultant Dermatologist, Cleveland Clinic Foundation, Cleveland, OH, US

Dr. Golara Honari is an up-and-coming researcher in the field of Dermatatoxicology, specializing in contact dermatitis. Additionally, Dr. Honari is an author of numerous peer-reviewed journal articles, book chapters, and international presentations.

Affiliations and Expertise

Consultant Dermatologist, Cleveland Clinic Foundation, OH, US

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