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Applied Dermatotoxicology - 1st Edition - ISBN: 9780124201309, 9780124201996

Applied Dermatotoxicology

1st Edition

Clinical Aspects

Authors: Howard Maibach Golara Honari
Paperback ISBN: 9780124201309
eBook ISBN: 9780124201996
Imprint: Academic Press
Published Date: 15th May 2014
Page Count: 150
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Applied Dermatotoxicology: Clinical Aspects provides concise, systematic, and state-of-the-art information on the toxicological effects of substances on skin, and recent advances in dermal toxicity testing.

This book specifically addresses the clinical presentations borne out of exposure to a variety of chemicals. It begins with an overview of skin biology to provide toxicologists with a basic understanding of its anatomy and physiology. Next it presents a variety of dermatotoxicological effects, as well at the toxic agents that cause them, with color photographs to illustrate these effects.

Applied Dermatotoxicology: Clinical Aspects is an essential reference for toxicologists in industry, and for those medical professionals who encounter cases of dermal exposure to toxic agents.

Key Features

  • A concise, yet inclusive review of effects of chemical exposure
  • Includes background on basic skin biology
  • Provides vital clinical reference for toxicologists in non-clinical settings


Applied Dermatotoxicology: Clinical Aspects is intended for toxicologists, and for those medical professionals who encounter cases of dermal exposure to toxic agents

Table of Contents

  • List of Contributors
  • Preface
  • Chapter 1. Skin Structure and Function
    • Introduction
    • Structure and Function
    • Skin Appendages
    • Skin a Route of Entry
    • Measuring Skin
    • References
  • Chapter 2. Irritant Contact Dermatitis: Clinical Aspects
    • Introduction
    • Clinical Manifestations of Irritant Dermatitis
    • Special Clinical Forms of Irritant Dermatitis
    • Summary
    • Toxicology
    • References
    • References
  • Chapter 3. Photoirritation (Phototoxicity): Clinical Aspects
    • Introduction
    • Basic Principles of Photobiology
    • Mechanisms of Phototoxic Reactions
    • Clinical Presentations
    • Main Topical and Systemic Photosensitizers
    • Summary
    • Phototoxicity Testing
    • References
    • References
  • Chapter 4. Allergic Contact Dermatitis: Clinical Aspects
    • Introduction
    • ACD Syndrome
    • Stage 1 of ACDS
    • Stage 2 of ACDS
    • Stage 3 of ACDS
    • ICD Versus ACD: Clinical Aspects
    • Hand Eczema (Hand Dermatitis) and ACD
    • Photoallergic Contact Dermatitis
    • ACD: The Patch Test, First-Line Diagnostic Tool
    • The Series of Patch Test Allergens
    • The Panoply of Additional Diagnostic Tools
    • Testing End-Products with Unknown Components
    • Treatment
    • Toxicology of Skin Sensitization
    • References
    • References
  • Chapter 5. Photoallergic Contact Dermatitis: Clinical Aspects
    • Definition and Background
    • History
    • Epidemiology
    • Mechanisms and Pathogenesis
    • Clinical Presentation of Photoallergic Contact Dermatitis
    • Investigation
    • Photopatch Testing Technique
    • Test Procedure
    • Test Material
    • Reading and Interpretation of Results
    • Current Common Topical Photoallergens
    • Regulatory Aspects
    • Toxicology of Photoallergy
    • References
    • References
  • Chapter 6. Contact Urticaria Syndrome: Clinical Aspects
    • Introduction
    • Clinical Features
    • Mechanisms and Common Causes
    • Differential Diagnosis
    • Diagnosis and Testing
    • Treatment and Prevention
    • Discussion
    • Toxicology of Contact Urticaria Syndrome
    • References
    • References


No. of pages:
© Academic Press 2014
15th May 2014
Academic Press
Paperback ISBN:
eBook ISBN:

About the Authors

Howard Maibach

Dr. Howard Maibach is an expert in contact and occupational dermatitis and sees patient at the Environmental Dermatosis Clinic, which is part of the Dermatology Clinic. His specialty is dermatotoxicology, or skin exposure toxicity; allergies and skin disorders; and dermatopharmacology or the study of medications for skin disorders.

Maibach has been on the editorial board of more than 30 scientific journals and is a member of 19 professional societies including the American Academy of Dermatology, San Francisco Dermatological Society and the Internal Commission on Occupation Health. He is a professor in the Department of Dermatology at UCSF.

To make an appointment with Maibach, patients need a referral from a primary care doctor or dermatologist.

Dr. Howard Maibach has written and lectured extensively on dermatotoxicology (the toxicity to man from skin exposure) and dermatopharmacology (the treatment of skin diseases). His current research programs include defining the chemical-biologic faces of irritant dermatitis and the study of percutaneous penetration.

When Dr. Maibach is not in the lab conducting research or in the classroom teaching, he is seeing patients at the Environmental Dermatoses Clinic (of the Dermatology Clinic), mostly providing second opinions on allergic contact dermatitis.

Dr. Maibach has been on the editorial boards of over 30 scientific journals and is a member of 19 professional societies including the American Academy of Dermatology, San Francisco Dermatological Society, and the International Commission on Occupational Health.

Affiliations and Expertise

Professor of Dermatology, University of California, San Francisco, USA

Golara Honari

Golara Honari, MD, FAAD, Consultant Dermatologist, Cleveland Clinic Foundation, Cleveland, OH, US

Dr. Golara Honari is an up-and-coming researcher in the field of Dermatatoxicology, specializing in contact dermatitis. Additionally, Dr. Honari is an author of numerous peer-reviewed journal articles, book chapters, and international presentations.

Affiliations and Expertise

Consultant Dermatologist, Cleveland Clinic Foundation, OH, US


" excellent introduction to the extremely valuable text for anybody interested in how chemical and environmental factors can impact adversely on the skin." --btsNews

"It discusses the nuances and current knowledge on performing testing…written for researchers and dermatologists interested in contact and irritant dermatitis on a basic science level. Score: 79 - 3 Stars", 2014

Ratings and Reviews