Applications of Viruses for Cancer Therapy, Volume 115

Table of Contents

Cover image

Contributors

Chapter One Cancer Terminator Viruses and Approaches for Enhancing Therapeutic Outcomes

1 Introduction

2 Viral Vectors for Cancer Gene Therapy

3 Adenoviruses as Vectors for Cancer Gene Therapy

4 Cancer Terminator Viruses: Efficacious Reagents for Cancer Gene Therapy

5 Approaches Enhancing Therapeutic Outcomes

6 Conclusions and Future Directions

Chapter Two Adenovirus Strategies for Tissue-Specific Targeting

1 Introduction

2 Ad Biology

3 Ad Capsid Structure

4 Ad Entry Biology

5 Transductional Targeting of Ad Vectors

6 Ad Transductional Targeting: Adapter-Based Strategies

7 FAB Antibody Adapters

8 Recombinant Fusion Adapters

9 Alternative Adapter Binding Locales

10 Adapters Utilizing Genetically Modified Ad Capsid

11 Ad Secretion of Adapter

12 Ad Transductional Targeting: Genetically Incorporated Strategies

13 Chimeric Ad

14 Peptide-Targeted Ad

15 “Knob-less”-Targeted Ad

16 Alternative Capsid Locations

17 Novel Transductional Strategies

18 Ad Targeting: Recent Clinical Developments

19 Concluding Remarks

Chapter Three Syrian Hamster as an Animal Model to Study Oncolytic Adenoviruses and to Evaluate the Efficacy of Antiviral Compounds

1 Introduction

2 Existing Animal Models

3 The Syrian Hamster Model

Chapter Four Design of Improved Oncolytic Adenoviruses

1 Introduction

2 Oncolytic Adenovirus Tumor Targeting

3 The Stroma Barrier to Oncolytic Adenovirus Spread

4 Antiadenovirus and Antitumor Immunity in the Outcome of Virotherapy

Chapter Five The Development of Transcription-Regulated Adenoviral Vectors with High Cancer-Selective Imaging Capabilities

1 Introduction

2 Preclinical Molecular Imaging Modalities

3 Cancer-Targeted Adenoviral Vector Gene Delivery

4 Transcriptional Amplification Strategies

5 Specific Applications

6 Concluding Remarks

Chapter Six Adenovirus-Based Immunotherapy of Cancer: Promises to Keep

1 Introduction: Promises to Keep

2 AdVs as Vaccine Vehicles

3 Optimizing AdVs for Clinical Translation

4 Ad-Based Tumor Immunotherapy Approaches: Vaccination and Beyond

5 Preclinical Models to Test Ad Cancer Vaccines

6 Next-Generation Ad Vaccines Against Cancer: The Way Forward

7 Concluding Remarks: Miles to Go

Chapter Seven Cancer Treatment with Gene Therapy and Radiation Therapy

1 Introduction

2 Molecular Mechanisms of Tumor Response to Radiation Therapy

3 Gene Transfer Systems

4 Radiation-Responsive Promoters

5 Therapeutic Transgenes

6 Molecular Chemotherapy and Radiation Therapy

7 Conclusion

Chapter Eight Oncolytic Adenoviruses for Cancer Immunotherapy

1 Introduction

2 Adenoviruses as Therapeutic Agents Against Cancer

3 Immune Recognition of Adenoviruses

4 Oncolytic Adenoviruses as Immunotherapeutic Agents

5 Final Remarks

Index

Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. This thematic volume looks at "Applications of viruses for cancer therapy". With outstanding and original reviews, this volume covers topics such as Cancer Terminator Viruses and Approaches for Enhancing Therapeutic Outcomes, esign of improved oncolytic adenoviruses, and Adenovirus-based immunotherapies for cancer.

• Provides invaluable information on the exciting and fast-moving field of cancer research
• This thematic volume looks at "Applications of viruses for cancer therapy"
• Outstanding and original reviews

Researchers and students in the basic and clinical sciences of cancer biology and oncology, plus related areas in genetics, immunology, pharmacology, cell biology, and molecular biology