Description

Advances in Cancer Research provides invaluable information on the exciting and fast-moving field of cancer research. This thematic volume looks at "Applications of viruses for cancer therapy". With outstanding and original reviews, this volume covers topics such as Cancer Terminator Viruses and Approaches for Enhancing Therapeutic Outcomes, esign of improved oncolytic adenoviruses, and Adenovirus-based immunotherapies for cancer.

Key Features

  • Provides invaluable information on the exciting and fast-moving field of cancer research
  • This thematic volume looks at "Applications of viruses for cancer therapy"
  • Outstanding and original reviews
  • Readership

    Researchers and students in the basic and clinical sciences of cancer biology and oncology, plus related areas in genetics, immunology, pharmacology, cell biology, and molecular biology.

    Table of Contents

    Table of Contents

    Cover image

    Contributors

    Chapter One Cancer Terminator Viruses and Approaches for Enhancing Therapeutic Outcomes

    1 Introduction

    2 Viral Vectors for Cancer Gene Therapy

    3 Adenoviruses as Vectors for Cancer Gene Therapy

    4 Cancer Terminator Viruses: Efficacious Reagents for Cancer Gene Therapy

    5 Approaches Enhancing Therapeutic Outcomes

    6 Conclusions and Future Directions

    Chapter Two Adenovirus Strategies for Tissue-Specific Targeting

    1 Introduction

    2 Ad Biology

    3 Ad Capsid Structure

    4 Ad Entry Biology

    5 Transductional Targeting of Ad Vectors

    6 Ad Transductional Targeting: Adapter-Based Strategies

    7 FAB Antibody Adapters

    8 Recombinant Fusion Adapters

    9 Alternative Adapter Binding Locales

    10 Adapters Utilizing Genetically Modified Ad Capsid

    11 Ad Secretion of Adapter

    12 Ad Transductional Targeting: Genetically Incorporated Strategies

    13 Chimeric Ad

    14 Peptide-Targeted Ad

    15 “Knob-less”-Targeted Ad

    16 Alternative Capsid Locations

    17 Novel Transductional Strategies

    18 Ad Targeting: Recent Clinical Developments

    19 Concluding Remarks

    Chapter Three Syrian Hamster as an Animal Model to Study Oncolytic Adenoviruses and to Evaluate the Efficacy of Antiviral Compounds

    1 Introduction

    2 Existing Animal Models

    3 The Syrian Hamster Model

    Chapter Four Design of Improved Oncolytic Adenoviruses

    1 Introduction

    2 Oncolytic Adenovirus Tumor Targeting

    3 The Stroma Barrier to Oncolytic Adenovirus Spread

    4 Antiadenovirus and Antitumor Immunity in the Outcome of Virotherapy

    Chapter Five The Development of Transcription-Regulated Adenoviral Vectors with High Cancer-Selective Imaging Capabilities

    1 Introduction

    2 Preclinical Molecula

    Details

    No. of pages:
    244
    Language:
    English
    Copyright:
    © 2012
    Published:
    Imprint:
    Academic Press
    Print ISBN:
    9780123983428
    Electronic ISBN:
    9780123983695