
Applications of Viruses for Cancer Therapy
Description
Key Features
- Provides invaluable information on the exciting and fast-moving field of cancer research
- This thematic volume looks at "Applications of viruses for cancer therapy"
- Outstanding and original reviews
Readership
Table of Contents
Table of Contents
Cover image
Contributors
Chapter One Cancer Terminator Viruses and Approaches for Enhancing Therapeutic Outcomes
1 Introduction
2 Viral Vectors for Cancer Gene Therapy
3 Adenoviruses as Vectors for Cancer Gene Therapy
4 Cancer Terminator Viruses: Efficacious Reagents for Cancer Gene Therapy
5 Approaches Enhancing Therapeutic Outcomes
6 Conclusions and Future Directions
Chapter Two Adenovirus Strategies for Tissue-Specific Targeting
1 Introduction
2 Ad Biology
3 Ad Capsid Structure
4 Ad Entry Biology
5 Transductional Targeting of Ad Vectors
6 Ad Transductional Targeting: Adapter-Based Strategies
7 FAB Antibody Adapters
8 Recombinant Fusion Adapters
9 Alternative Adapter Binding Locales
10 Adapters Utilizing Genetically Modified Ad Capsid
11 Ad Secretion of Adapter
12 Ad Transductional Targeting: Genetically Incorporated Strategies
13 Chimeric Ad
14 Peptide-Targeted Ad
15 “Knob-less”-Targeted Ad
16 Alternative Capsid Locations
17 Novel Transductional Strategies
18 Ad Targeting: Recent Clinical Developments
19 Concluding Remarks
Chapter Three Syrian Hamster as an Animal Model to Study Oncolytic Adenoviruses and to Evaluate the Efficacy of Antiviral Compounds
1 Introduction
2 Existing Animal Models
3 The Syrian Hamster Model
Chapter Four Design of Improved Oncolytic Adenoviruses
1 Introduction
2 Oncolytic Adenovirus Tumor Targeting
3 The Stroma Barrier to Oncolytic Adenovirus Spread
4 Antiadenovirus and Antitumor Immunity in the Outcome of Virotherapy
Chapter Five The Development of Transcription-Regulated Adenoviral Vectors with High Cancer-Selective Imaging Capabilities
1 Introduction
2 Preclinical Molecular Imaging Modalities
3 Cancer-Targeted Adenoviral Vector Gene Delivery
4 Transcriptional Amplification Strategies
5 Specific Applications
6 Concluding Remarks
Chapter Six Adenovirus-Based Immunotherapy of Cancer: Promises to Keep
1 Introduction: Promises to Keep
2 AdVs as Vaccine Vehicles
3 Optimizing AdVs for Clinical Translation
4 Ad-Based Tumor Immunotherapy Approaches: Vaccination and Beyond
5 Preclinical Models to Test Ad Cancer Vaccines
6 Next-Generation Ad Vaccines Against Cancer: The Way Forward
7 Concluding Remarks: Miles to Go
Chapter Seven Cancer Treatment with Gene Therapy and Radiation Therapy
1 Introduction
2 Molecular Mechanisms of Tumor Response to Radiation Therapy
3 Gene Transfer Systems
4 Radiation-Responsive Promoters
5 Therapeutic Transgenes
6 Molecular Chemotherapy and Radiation Therapy
7 Conclusion
Chapter Eight Oncolytic Adenoviruses for Cancer Immunotherapy
1 Introduction
2 Adenoviruses as Therapeutic Agents Against Cancer
3 Immune Recognition of Adenoviruses
4 Oncolytic Adenoviruses as Immunotherapeutic Agents
5 Final Remarks
Index
Product details
- No. of pages: 244
- Language: English
- Copyright: © Academic Press 2012
- Published: October 3, 2012
- Imprint: Academic Press
- eBook ISBN: 9780123983695
- Hardcover ISBN: 9780123983428
About the Serial Volume Editors
David Curiel

Affiliations and Expertise
Paul Fisher
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