Applications of Nuclear Magnetic Resonance Spectroscopy in Organic Chemistry

Applications of Nuclear Magnetic Resonance Spectroscopy in Organic Chemistry

2nd Edition - January 1, 1969

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  • Authors: L. M. Jackman, S. Sternhell
  • eBook ISBN: 9781483280943

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Description

Application of Nuclear Magnetic Resonance Spectroscopy in Organic Chemistry, Second Edition covers the theoretical background necessary for the intelligent application of NMR spectroscopy to common problems encountered in organic chemistry. This book is composed of five parts, and begins with introduction to the theory and practice of nuclear magnetic resonance. The succeeding chapter deals with the theory of chemical effects in NMR spectroscopy. These topics are followed by a discussion on the application of chemical shift to organic compound analysis and the principles of the spin-spin coupling .The final chapter considers the applications of time- dependent phenomena in NMR spectroscopy. This book will prove useful to analytical chemists and researchers in the allied fields.

Table of Contents


  • Preface

    Preface to the 1st Edition

    Editorial Preface to the 2nd Edition

    Part 1 an Introduction to the Theory and Practice of Nuclear Magnetic Resonance Spectroscopy

    Chapter 1-1. Theory of Nuclear Magnetic Resonance

    A. Dynamic and Magnetic Properties of Atomic Nuclei

    B. Nuclear Resonance

    C. Relaxation Processes

    D. Chemical Effects in N.M.R.

    Chapter 1-2. The Experimental Method

    A. The Nuclear Magnetic Resonance Spectrometer

    B. Experimental Factors which Influence Resolution and the Shapes of Absorption Lines

    C. Experimental Factors which Influence Sensitivity (Signal-To-Noise Ratio)

    D. Measurement of Line Positions and Determination of the Chemical Shift

    E. Measurement of Intensities

    F. Solvents

    G. Deuterium Exchange

    Part 2 Theory of Chemical Effects in Nuclear Magnetic Resonance Spectroscopy

    Chapter 2-1. Time-Dependent Effects in Nuclear Magnetic Resonance Spectroscopy

    Chapter 2-2. Theory of the Chemical Shift

    A. Classification of Shielding Effects

    B. Local Diamagnetic Proton Shielding

    C. Long Range Shielding

    D. Contact Shifts

    E. The Hydrogen Bond

    F. Solvent Effects

    Chapter 2-3. Theory of Spin-Spin Multiplicity

    A. Recognition of Spin-Spin Multiplets

    B. The Mechanism of Spin-Spin Coupling

    C. Analysis of N.M.R. Spectra

    Chapter 2-4. Theory and Applications of Multiple Irradiation

    A. Theory

    B. Applications

    Part 3 Applications of the Chemical Shift

    Chapter 3-1. General Considerations

    Chapter 3-2. Protons Bonded to Non-Cyclic Sp3 Carbon Atoms

    A. H—C—C

    B. H—C—X

    C. Effect of Multiple Substitution At the α-Carbon Atom

    Chapter 3-3. Protons Bonded to Non-Aromatic Sp2 Carbon Atoms

    A. Olefinic Protons H—C=C

    B. Formyl Protons H—C=X

    Chapter 3-4. Protons Bonded to Sp Carbon Atoms

    Chapter 3-5. Protons Bonded to Sp3 Carbon Atoms in Non-Aromatic Cyclic Structures

    Chapter 3-6. Protons Bonded to Aromatic and Heterocyclic Carbon Atoms

    A. Benzene Derivatives

    B. Polynuclear and non-Benzenoid Carbocyclic Aromatic Compounds

    C. Heterocyclic Compounds

    Chapter 3-7. Protons Bonded to Elements other than Carbon

    A. —OH, —NH and —SH Groups

    Chapter 3-8. Stereochemistry And The Chemical Shift

    A. Symmetry Arguments

    B. Geometrical Isomerism in Ethylene Derivatives

    C. Geometrical Isomerism in Systems Containing C=N and N = N Bonds

    D. Cyclopropanes and Heterocyclopropanes

    E. Multi-Ring Structures

    F. Cis-Trans Stereochemistry in Four-, Five-, and Six-Membered Rings

    G. The Chemical Shifts of Axial and Equatorial Protons and Groups Attached to Six-Membered Rings in Chair Conformation

    H. Chemical Shift—Stereochemistry Correlations in some Complex Natural Products

    I. Conformation

    J. Stereochemistry and the Solvent Shift

    Chapter 3-9. Carbonium Ions, Carbanions and Related Systems

    A. Carbonium Ions

    B. Carbanions

    Part 4 Spin-Spin Coupling

    Chapter 4-1. Geminal Interproton Coupling

    A. Geminal Coupling Across an Sp2 Carbon Atom

    B. Geminal Coupling Across an Sp2 Carbon Atom

    C. Geminal Coupling Across a Heteroatom

    Chapter 4-2. Vicinal Interproton Coupling

    A. Vicinal Coupling Across Three Single Bonds

    B. Vicinal Interproton Coupling Across One Double and Two Single Bonds

    Chapter 4-3. Interproton Coupling in Aromatic and Heterocyclic Systems

    A. Influence of Ring Size

    B. Influence of Bond Order

    C. Effects due to Heteroatoms

    D. Effects due to Substituents

    Chapter 4-4. Long-Range Interproton Coupling

    A. Observation of Long-Range Coupling

    B. Theory of Long-Range Coupling

    C. Allylic and Homoallylic Coupling

    D. Long-Range Coupling in Acetylenes, Allenes and Cumulenes

    E. Benzylic Coupling

    F. Coupling between Protons Separated by Five Bonds Along an Extended Zig-Zag Path

    G. Coupling Across Four Single Bonds

    H. Long-Range Coupling in 1,3-Butadiene Derivatives

    I. Miscellaneous Examples of Long-Range Coupling

    Chapter 4-5. Coupling between Protons and other Nuclei

    A. Coupling between 1H and 13C

    B. Coupling between 1H and 19F

    C. Coupling between 1H and 31P

    D. Coupling between Protons and Other Elements

    Part 5 Applications of Time-Dependent Phenomena

    Chapter 5-1. General Applications

    A. Experimental Methods Involved in the Study of Time-Dependent Phenomena in N.M.R. Spectroscopy

    B. Hydrogen Exchange and Hydrogen Bonding

    C. Ligand Exchange

    D. Partial Double Bond Character

    E. Valence-Bond Tautomerism

    F. Conformational Changes

    G. Miscellaneous Processes

    Chapter 5-2. Internal Rotation and Equivalence of Nuclei

    Chapter 5-3. Tautomerism

    References

    Index

    Other Titles in the Series




Product details

  • No. of pages: 474
  • Language: English
  • Copyright: © Pergamon 1969
  • Published: January 1, 1969
  • Imprint: Pergamon
  • eBook ISBN: 9781483280943

About the Authors

L. M. Jackman

S. Sternhell

About the Editors

D. H. R. Barton

W. Doering

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