Applications of Nanotechnology in Drug Discovery and Delivery, in the Drug Discovery Update series, presents complete coverage of the application of nanotechnology in the discovery of new drugs and efficient target delivery of drugs. The book highlights recent advances of nanotechnology applications in the biomedical sciences, starting with chapters that provide the basics of nanotechnology, nanoparticles and nanocarriers. Part II deals with the application of nanotechnology in drug discovery, with an emphasis on enhanced delivery of pharmaceutical products, with Part III discussing toxicological and safety issues arising from the use of nanomaterials. This book brings together a global team of experts, making it an essential resource for researchers, drug developers, medicinal chemists, toxicologists and analytical chemists.
Serves as a guide to drug developers working in pharma, biotech and academia, bringing together the latest research on the topic
Presents recent information on the use of nanomaterials for the development of drugs using engineered nanocarriers to target specific delivery
Features a global team of contributing experts who discuss nanotechnology applications in drug discovery as well as safety issues and challenges
Researchers in organic and medicinal chemistry including drug developers, medicinal chemists, toxicologists, and analytical chemists
Table of Contents
Part 1: Fundamentals of Nanotechnology Application in Drug Discovery 1. Nanotechnology: History, Trends and Modern Application 2. Nanomaterials as Drug Candidates: Types, Synthesis and Preparatory Methods 3. Factors Affecting the Choice for Nanoparticles in Drug Discovery 4. Nanoparticle Formulation: Types, Steps and Procedures 5. Nanocarriers: Types, Synthesis and Fabrication Methods 6. Factors Affecting the Choice for Nanocarriers for Efficient Drug Delivery Applications 7. Characterization of Nanoparticles: Methods and Techniques
Part II: Application of Nanotechnology in Drug Discovery and Therapy 8. Applications of Nanotechnology in Pharmaceutical Products 9. Applications of Nanotechnology in Target Identification and Validation 10. Applications of Nanotechnology in Lead Identification and Optimization 11. Application of Nanotechnology in Pharmaceutical Product Delivery 12. Application of Nanotechnology in Medicine in the Treatment of Diseases
Part III: Safety Issues and Challenges 13. Nanotoxicology: Toxicity of Nanoparticles in Biomedical Application 14. In vitro and In vivo Toxicity of Metal Nanoparticles and their Drug Delivery Applications 15. Application of Nanoelectromechanical Systems for the Detection of Toxic Chemical Agents in Pharmaceutical Products: Nanobiosensor Application 16. Policy Issues, Risk Assessment and Regulations of the Application of Nanotechnology in Drug Discovery
Chukwuebuka Egbuna is a chartered chemist, a chemical analyst, and an academic researcher. He is a member of the Institute of Chartered Chemists of Nigeria (ICCON), the Nigerian Society of Biochemistry and Molecular Biology (NSBMB), the Society of Quality Assurance (SQA) (USA), and the Royal Society of Chemistry (RSC) (United Kingdom).
Egbuna is also an editor of new Elsevier series on Drug Discovery Update. The series includes books, monographs and edited collections from all areas of drug discovery, including emerging therapeutic claims for the treatment of diseases. He has been engaged in a number of roles at New Divine Favor Pharmaceutical Industry Limited, Akuzor Nkpor, Anambra State, Nigeria, and Chukwuemeka Odumegwu Ojukwu University (COOU) in Nigeria. He has collaboratively worked and published quite a number of research articles in the area of phytochemistry, nutrition and toxicology and related areas. He is a reviewer and editorial board member of various journals, including serving as a website administrator for the Tropical Journal of Applied Natural Sciences (TJANS), a journal of the faculty of Natural Sciences, COOU and as an advisory board member under toxicology for the book publisher, Cambridge Scholar Publishing. His primary research interests are in phytochemistry, nutrition and toxicology, food and medicinal chemistry, and analytical biochemistry.
Affiliations and Expertise
Nutritional Biochemistry Unit, Africa Centre of Excellence in Public Health and Toxicological Research (ACE-PUTOR), University of Port-Harcourt, Rivers State; Department of Biochemistry, Chukwuemeka Odumegwu Ojukwu University, Uli, Nigeria
Mihnea-Alexandru Găman received his M.D. at the Faculty of Medicine, “Carol Davila” University of Medicine and Pharmacy, Bucharest, Romania. Dr. Găman is currently specialising in Clinical Haematology at the Department of Haematology, Centre of Haematology and Bone Marrow Transplantation, Fundeni Clinical Institute, Bucharest, Romania. Dr. Găman conducts research in the fields of Haematology, Oncology, Molecular and Cell Biology, Internal Medicine, Pharmacology, Pharmacy and Pharmaceutical Sciences, and has published over 30 papers in international and national impact factor journals, as well as served as editor and author for international and national books/book chapters. Dr. Găman has also been appointed as Scientific Editor for the International Journal of Medical Students (IJMS) and has served as peer-reviewer for over 50 international and national journals. Dr. Găman has received training in his home country, Romania, as well as Germany, Italy, Poland and the United States of America as part of several research teams.
Affiliations and Expertise
Specialist, Clinical Haemotology, Department of Haemotology, Centre of Haemotology and Bone Marrow Transplantation, Fundeni Clinical Institute, Bucharest, Romania
Dr. Jaison Jeevanandam is currently working as a senior researcher in Centro De Quimica Da Madeira (CQM – Center for Chemistry), University of Madeira, Portugal. He obtained his Ph.D. in the Department of Chemical Engineering, Faculty of Engineering and Science from Curtin University, Malaysia. He has experience in nanoparticle synthesis, especially in the green synthesis using plant extracts, characterization, cytotoxic analysis of nanoparticles, and in vitro analysis in diabetic models. His current research focuses on the application of nanobiotechnology in the development of nanoformulations for drug delivery systems. He has won several awards, including ‘Best teacher award 2019’ from Academy of competitive exam and research training (ACERT, Chennai), India; Gold medal in 3rd World Invention Innovation Contest (WiC) in 2017 from Korea Invention News (South Korea); Special honor of invention award, 3rd World Invention Innovation Contest (WiC) in 2017 from Toronto International Society of Innovation & Advanced Skills (TISIAS) (Canada). Dr. Jaison has authored +50 articles. Further, Dr. Jaison serves as a journal editor for Bio-integration (China) and International Archives of Biomedical and Engineering Sciences (India), as well as an invited editor for special issue in applied sciences (MDPI), Frontiers in Bioengineering and Biotechnology (Research topic coordinator) and Frontiers in molecular biosciences; and reviewer for 10+ journals.
Affiliations and Expertise
Senior Researcher, CQM - Centro De Quimica Da Madeira, MMRG, Universidade Da Madeira, Funchal, Madeira, Portugal