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Applications of Nanobiotechnology for Neglected Tropical Diseases - 1st Edition - ISBN: 9780128211007, 9780128211014

Applications of Nanobiotechnology for Neglected Tropical Diseases

1st Edition

Editors: Fabio Rocha Formiga Inamuddin Patricia Severino
Paperback ISBN: 9780128211007
eBook ISBN: 9780128211014
Imprint: Academic Press
Published Date: 20th February 2021
Page Count: 604
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Applications of Nanobiotechnology for Neglected Tropical Diseases describes recent advances in nanobiotechnology that can be applied to reducing the global disease burden of neglected tropical diseases (NTDs). The book explores the application of nanotechnology on the development of safe, effective, and reliable tools to prevent, diagnose, and treat NTDs.

Furthermore, Applications of Nanobiotechnology for Neglected Tropical Diseases includes multidisciplinary content, combining knowledge from biochemistry, medicinal chemistry, material sciences, pharmacology, and pharmaceutics. The book is divided into three main parts, each outlining one major type of approach: (1) nano-based approaches for prevention, (2) nano-diagnostics and detection, and (3) nanotherapeutics. Each part contains chapters that delve into the different applications of the type of approach being presented in that part. A discussion of other approaches against NTD follows these three parts. This book is remarkable in its ability to encompass and thoroughly explain the latest techniques in nanobiotechnology, from basic research to patient-oriented investigation.

Key Features

  • Offers a broad overview of nanobiotechnology applied to the prevention, diagnostics, and treatment of NTDs
  • Presents cutting-edge recent advances in nanobiotechnology, focusing on diseases reported by the World Health Organization’s NTDs Roadmap (e.g., leishmaniasis, malaria, schistosomiasis, filariasis, etc.)
  • Provides a deep discussion about ground-breaking approaches designed to meet the medical needs of patients suffering from NTDs
  • Gives examples of multidisciplinary investigations into NTDs, from research labs to clinics


Undergraduate and graduate students, scientists and professors in multidisciplinary fields such as immunology, microbiology, biotechnology, nanomedicine, chemical and material engineering and pharmaceutical technology. Readers of interrelated areas such as parasitology, immunology or infectology may also be included in a target audience. Still, technicians and R&D corporate personal of biotech and pharmaceutical industries are potential readers

Table of Contents

Part I: Nano-based approaches for prevention of NTD
1. Experimental vaccination with nanoparticles containing Escherichia coli virulence factors
2. Vaccine as immunotherapy for leishmaniasis
3. Polymeric particles as a delivery agent for malarial vaccines

Part II: Nano-Diagnostics and Detection of NTD
4. The use of nano-enabled technologies to diagnose dengue virus infections
5. Multiplexed detection with nanodiagnostics
6. Nanosensor for the detection of malaria parasite

Part III: Nanotherapeutics for NTD
7. Developing effective amphotericin B delivery systems for fungal infections
8. Development of nanocarriers for innovative antimalarial combination strategies
9. Nanomedicines against Chagas disease
10. Nanoformulations of old and new antimalarial drugs
11. Drug repurposing and nanoparticles: New strategies against leishmaniasis
12. Nanoformulations for new compounds against leishmaniasis
13. Improving the miltefosine efficacy against leishmaniasis by using nanoassemblies made from surfactants or amphiphilic antimony (V) complex
14. Trendings of amphotericin B-loaded nanoparticles as valuable chemotherapeutic approaches against leishmaniasis
15. Nanopharmaceuticals to target antifilarials: Administration of old age drugs in a novel way
16. Lipid nanoparticles for the treatment of neglected tropical diseases
17. Experimental treatment of Schistosomiasis mansoni using praziquantel-free and encapsulated into nanostructures

Part IV: Other approaches for NTD
18. Bionanocomposite assembly with larvicidal activity against Aedes aegypti
19. Microfilaricidal efficacy of silver nanoparticles
20. Self-assembled nanocarriers as biotechnology approach to antivenom immunotherapy
21. Novel processes combining natural products and synthetic materials for developing nanolarvicides
22. Development of eco-friendly nano-mosquitocides against arboviruses vectors
23. Systems biology and bioinformatics approaches in leishmaniasis
24. May nanoparticles offer chances to avoid the development of insecticide resistance in mosquitoes?


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© Academic Press 2021
20th February 2021
Academic Press
Paperback ISBN:
eBook ISBN:

About the Editors

Fabio Rocha Formiga

Fabio Rocha Formiga graduated in pharmaceutical sciences, obtaining his bachelor’s degree in 2004 from the Federal University of Rio Grande do Norte, Brazil, where he also concluded a master’s course in health sciences. In 2011, he obtained a PhD in pharmaceutical technology from the University of Navarra in Spain, with distinctions, as a MAEC-AECID scholar. In 2018, he completed a research training in nanobiomaterials at the Rice University (Houston, United States). Dr. Formiga has worked as a visiting professor at the University of Coimbra, Portugal. He has experience in teaching/supervision at the BSc, MSc, and PhD levels. In addition, he has acted as referee for national and foreign funding agencies. He has participated as a member of university committees, examination boards, and has organized scientific meetings, including the 22nd International Symposium on Microencapsulation (Chair). Dr. Formiga has also been strongly involved in collaborative programs for exchange with European universities (from Portugal, Spain, and Denmark). He is a cofounder and vice-president of the Brazilian Chapter of Controlled Release Society (CRS, 2019–present) and guest associate editor of the Drug Delivery and Translational Research (Springer) and Pharmaceutical Nanotechnology (Bentham). He is a member of the Brazilian Association of Pharmaceutical Sciences (ABCF) and the European Foundation for Clinical Nanomedicine (CLINAM). Currently, Dr. Formiga is a research scientist and deputy head of the Department of Immunology at the Aggeu Magalhães Institute, Oswaldo Cruz Foundation (FIOCRUZ), Brazil. He also holds a tenured adjunct professor position at University of Pernambuco (UPE). Dr. Formiga was acknowledged with the Research Award from Spanish Society of Pharmaceutics and Pharmaceutical Technology (SEFIG) in 2013 and the Benjamin Gilbert Award from FIOCRUZ in 2017. His research has focused on pharmaceutics, drug delivery, nanotechnology, and biomaterials toward neglected tropical diseases and regenerative medicine.

Affiliations and Expertise

Aggeu Magalhães Institute, Oswaldo Cruz Foundation (FIOCRUZ) and University of Pernambuco (UPE), Recife, Pernambuco, Brazil

Patricia Severino

Dr. Severino is currently working as a professor in the College of Pharmacy and Postgraduate Program in Industrial Biotechnology, Tiradentes University (UNIT), Aracaju, Brazil and is also a research coordinator of Nanomedicine and Nanotechnology Laboratory Institute of Technology and Research (ITP), Aracaju, Brazil. She graduated in pharmacy from the Methodist University of Piracicaba—Unimep (2005). She earned master’s and PhD from the Faculty of Chemical Engineering at the State University of Campinas—Unicamp (2008 and 2012). In the master's she carried out a sandwich program at the Faculty of Pharmacy of the Federal University of Rio Grande do Sul—UFRGS (2007–08), and in her PhD carried out a sandwich program at the Faculty of Pharmacy of the Fernando Pessoa University—UFP, Porto, Portugal (2010–11). She has extensive research experience in multidisciplinary fields of nanomedicine, biomaterial, drug delivery, cosmetics, and biotechnology. She has published about 110 research articles in various international scientific journals, 24 book chapters, and 16 patents. She is a member of editorial boards of variousjournals. She has worked in technical-scientific collaboration with researchers from different institutions in the country and abroad, such as the United States, England, the Czech Republic, EUA, Italy, Turkey, India, and Portugal. She is a CNPq research productivity scholar (PQ-2). Currently, she is working in the internationalization process of UNIT at the Tiradentes Institute (TI-UMass) and is a visiting professor at Brigham and Women’s Hospital/Harvard Medical School, Cambridge, Massachusetts, United States.

Affiliations and Expertise

Tiradentes University (UNIT), Aracaju, Brazil Coordinator, Laboratory of Nanotechnology and Nanomedicine (LNMed), Aracaju, Brazil

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