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Applications of High Resolution Mass Spectrometry: Food Safety and Pesticide Residue Analysis is the first book to offer complete coverage of all aspects of high resolution mass spectrometry (HRMS) used for the analysis of pesticide residue in food. Aimed at researchers and graduate students in food safety, toxicology, and analytical chemistry, the book equips readers with foundational knowledge of HRMS, including established and state-of-the-art principles and analysis strategies. Additionally, it provides a roadmap for implementation, including discussions of the latest instrumentation and software available.
Detailed coverage is given to the application of HRMS coupled to ultra high-performance liquid chromatography (UHPLC-HRMS) in the analysis of pesticide residue in fruits and vegetables and food from animal origin.
The book also discusses extraction procedures and the challenges of sample preparation, gas chromatography coupled to high resolution mass spectrometry, flow injection-HRMS, ambient ionization, and identification of pesticide transformation products in food. Responding to the fast development and application of these new procedures, this book is an essential resource in the food safety field.
- Arms researchers with an in-depth resource devoted to the rapid advances in HRMS tools and strategies for pesticide residue analysis in food
- Provides a complete overview of analytical methodologies and applications of HRMS, including UHPLC-HRMS, HRMS coupled with time of flight (TOF) and/or GC-Orbitrap, and flow injection-HRMS
- Discusses the current international regulations and legislation related to the use of HRMS in pesticide residue analysis
- Features a chapter on the hardware and software available for HRMS implementation
- Offers separate chapters on HRMS applied to pesticide residue analysis in fruits and vegetables and in food from animal origin
Researchers in universities, government agencies, and private industry in food safety, food chemistry, analytical chemistry, and toxicology; and graduate students in these areas
Chapter 1. HRMS: Fundamentals and Basic Concepts
- 1.1. Introduction (To High-Resolution Mass Spectrometry)
- 1.2. Resolution and Mass Resolving Power
- 1.3. Accurate Mass Measurement: Exact Mass and Mass Defect
- 1.4. Mass Calibration in High-Resolution Mass Spectrometry
- 1.5. General Considerations
Chapter 2. HRMS: Hardware and Software
- 2.1. Introduction
- 2.2. Principles of High-Resolution Mass Spectrometry Analyzers
- 2.3. Time-of-Flight Mass Spectrometry: Instrument Configuration and Main Features
- 2.4. Orbitrap Analyzers: Instrument Configurations and Main Features
- 2.5. Acquisition Modes in High-Resolution Mass Spectrometry
- 2.6. Databases and the Internet Resources for High-Resolution Mass Spectrometry
Chapter 3. Analytical Strategies Used in HRMS
- 3.1. Introduction
- 3.2. Advantages of High-Resolution Mass Spectrometry in Pesticide Analysis
- 3.3. Data Analysis Workflows in High-Resolution Mass Spectrometry
- 3.4. Conclusions
Chapter 4. Current Legislation on Pesticides
- 4.1. Introduction
- 4.2. Pesticides
- 4.3. Legislation
- 4.4. Analytical Quality Control—Method Validation
- 4.5. Mass Spectrometry in Pesticide Residue Analysis
Chapter 5. Advanced Sample Preparation Techniques for Pesticide Residues Determination by HRMS Analysis
- 5.1. Introduction
- 5.2. Matrix Effects and the Influence of Coextracted Components
- 5.3. Sample Preparation Techniques for Pesticide Residue Determination by Chromatographic Techniques Coupled to High-Resolution Mass Spectrometry
- 5.4. Perspectives and Conclusions
Chapter 6. Applications of Liquid Chromatography Coupled With High-Resolution Mass Spectrometry for Pesticide Residue Analysis in Fruit and Vegetable Matrices
- 6.1. Introduction
- 6.2. Applications of Pesticide Residue Analysis in Fruit and Vegetable Samples by LC-HRMS
- 6.3. Optimized Sample Preparation and Chromatographic Conditions for Mass Analyzers
- 6.4. Analytical Method Validation
- 6.5. Accurate Measurement of Pesticide Residues in Fruit and Vegetable Samples
- 6.6. Evaluation of Pesticide Residues in Fruit and Vegetable Samples
- 6.7. Conclusion
Chapter 7. Application of HRMS in Pesticide Residue Analysis in Food From Animal Origin
- 7.1. Introduction
- 7.2. Instrumental Requirements
- 7.3. Analytical Procedures: Extraction and Chromatographic Conditions
- 7.4. Quantitative and Qualitative Applications
- 7.5. Differences Between Low-Resolution Mass Spectrometry and High-Resolution Mass Spectrometry Analytical Methods
- 7.6. Overview and Future Perspectives
Chapter 8. Recent Advances in HRMS Analysis of Pesticide Residues Using Atmospheric Pressure Gas Chromatography and Ion Mobility
- 8.1. Introduction
- 8.2. Atmospheric Pressure Gas Chromatography
- 8.3. Time-of-Flight Mass Spectrometry
- 8.4. Ion Mobility Separation
- 8.5. Summary and Conclusion
Chapter 9. Direct Analysis of Pesticides by Stand-Alone Mass Spectrometry: Flow Injection and Ambient Ionization
- 9.1. Introduction
- 9.2. Flow Injection Analysis
- 9.3. Ambient Mass Spectrometry
- 9.4. Final Remarks and Future Trends
Chapter 10. Identification of Pesticide Transformation Products in Food Applying High-Resolution Mass Spectrometry
- 10.1. Introduction
- 10.2. Experimental
- 10.3. Imidacloprid Metabolites in Plants
- 10.4. Imazalil Metabolites in Plants and Soil
- 10.5. Propiconazole Metabolites in Plants and Soil
- 10.6. Conclusions
- No. of pages:
- © Elsevier 2017
- 9th March 2017
- Paperback ISBN:
- eBook ISBN:
Roberto Romero-González received his PhD in Chemistry in 2002 from the University of Granada, Spain. After two years postdoctoral work at the University of Lund, Sweden, he joined the research group “Analytical Chemistry of Contaminants” (University of Almería, Spain). Since December 2008, he has obtained several contracts (i. e. Ramón y Cajal Program) as senior researcher at the University of Almería. He is the co-author of more than 90 research papers published in international journals related to the determination of bioactive compounds, contaminants, and organic residues in environmental and food matrices, applying chromatographic techniques coupled to mass spectrometry analysers (high and low resolution).
Department of Chemistry and Physics, University of Almería, Almería, Spain
Antonia Garrido Frenich is full professor of Analytical Chemistry at the University of Almería, Spain. She heads the research group “Analytical Chemistry of Contaminants,” where her research is focused on developing analytical methods for the simultaneous determination of different classes of residues and organic contaminants in environmental, biological, and food matrices, based on the application of chromatographic techniques coupled to low and high resolution mass analysers. She is author or co-author of more than 240 research papers and book chapters related to these topics.
Department of Chemistry and Physics, University of Almería, Almería, Spain
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