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Anxiety - 1st Edition - ISBN: 9780128119143, 9780128119150

Anxiety, Volume 103

1st Edition

Serial Editor: Gerald Litwack
eBook ISBN: 9780128119150
Hardcover ISBN: 9780128119143
Imprint: Academic Press
Published Date: 3rd January 2017
Page Count: 378
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Table of Contents

Chapter One: Stress, Anxiety, and Immunomodulation: A Pharmacological Analysis

  • Abstract
  • 1 Introduction
  • 2 Mechanism of Stress Response
  • 3 Stress, CNS, and Behavior
  • 4 Stress and Anxiety
  • 5 Stress and Various Anxiolytic Drugs
  • 6 Stress and Immunity
  • 7 Stress, Anxiety, and Immunomodulation

Chapter Two: Estrogen Receptors Modulation of Anxiety-Like Behavior

  • Abstract
  • 1 Introduction
  • 2 Nuclear Estrogen Receptor Form and Function
  • 3 Estrogen Receptor Alpha
  • 4 Estrogen Receptor Beta
  • 5 G-Protein-Coupled Estrogen Receptor
  • 6 Cross Talk Between Estrogen Receptors
  • 7 Mechanisms for Estrogen Receptor Effects on Anxiety
  • 8 Conclusions

Chapter Three: Neuroendocrine Underpinnings of Increased Risk for Posttraumatic Stress Disorder in Women

  • Abstract
  • 1 Introduction
  • 2 Case Example: PACAP Receptor Genetics

Chapter Four: The Big Role of Small RNAs in Anxiety and Stress-Related Disorders

  • Abstract
  • 1 Introduction
  • 2 Epigenetics
  • 3 MicroRNAs
  • 4 Insights into miRNAs Through the Use of Animal Models
  • 5 Investigating miRNAs in Anxiety Disorders
  • 6 Conclusion
  • Acknowledgments

Chapter Five: Natriuretic Peptides in Anxiety and Panic Disorder

  • Abstract
  • 1 Neuroendocrine Factors in Anxiety and Fear-Related Disorders
  • 2 Molecular Mechanisms Involved in Natriuretic Peptide Synthesis
  • 3 Expression of Natriuretic Peptides and Their Receptors in the Brain
  • 4 Physiological Actions of Natriuretic Peptides in the Brain
  • 5 Neuroprotective Effects of Natriuretic Peptides
  • 6 Evidence of Anxiolytic-Like Effects of ANP

Chapter Six: Role of Nitric Oxide in Stress-Induced Anxiety: From Pathophysiology to Therapeutic Target

  • Abstract
  • 1 Introduction
  • 2 Summary
  • Acknowledgment

Chapter Seven: Nitric Oxide and Anxiety

  • Abstract
  • 1 Introduction
  • 2 Nitric Oxide
  • 3 Conclusion

Chapter Eight: The Endocannabinoid System and Anxiety

  • Abstract
  • 1 Introduction
  • 2 eCBs and Anxiety in Humans
  • 3 eCBs in Animal Models of Fear and Anxiety
  • 4 Brain Sites Modulating Cannabinoid Effects in Animal Models
  • 5 Additional Mechanisms Involved in the eCB Effects on Anxiety
  • 6 Closing Remarks and Future Directions
  • Acknowledgments

Chapter Nine: The Melatonergic System in Anxiety Disorders and the Role of Melatonin in Conditional Fear

  • Abstract
  • 1 Introduction
  • 2 Anxiety and Melatonergic System
  • 3 PTSD and Pavlovian Fear Conditioning and Extinction
  • 4 Methods
  • 5 Results
  • 6 Discussion
  • Acknowledgments

Chapter Ten: The Role of Elements in Anxiety

  • Abstract
  • 1 Introduction
  • 2 Animal Models of Anxiety
  • 3 Zinc
  • 4 Magnesium
  • 5 Copper
  • 6 Lithium
  • 7 Iron
  • 8 Manganese
  • 9 Conclusions
  • Acknowledgment

Chapter Eleven: The Place of Stress and Emotions in the Irritable Bowel Syndrome

  • Abstract
  • 1 Introduction
  • 2 Pathophysiology of the IBS
  • 3 The Brain–Gut Axis
  • 4 The Output of the Central Autonomic Network and Stress Biological System
  • 5 Emotions and Stress in IBS
  • 6 Therapeutic Implications—Treatment Targeting Amygdala Activity Reduction and Vagal Tone Reinforcement in IBS: Mindfulness and Hypnosis
  • 7 Conclusion


Anxiety, the latest volume in the Vitamins and Hormones series first published in 1943, and the longest-running serial published by Academic Press, provides up-to-date information on the roles that hormones and other factors play in anxiety and stress.

Each volume focuses on a single molecule or disease that is related to vitamins or hormones, with the topic broadly interpreted to include related substances, such as transmitters, cytokines, growth factors, and others thoroughly reviewed.

Key Features

  • Provides cutting-edge reviews concerning the molecular and cellular biology of vitamins and hormones
  • Contains expertise from world-renowned contributors
  • Includes coverage of a vast array of subjects
  • Presents in-depth, current information from the molecular to clinical level


Researchers, faculty, and graduate students interested in cutting-edge reviews concerning the molecular and cellular biology of vitamins, hormones, and related factors and co-factors. Libraries and laboratories at institutes with strong programs in cell biology, biochemistry, molecular biology, gene regulation, hormone control, and signal transduction are likely to be interested


No. of pages:
© Academic Press 2017
3rd January 2017
Academic Press
eBook ISBN:
Hardcover ISBN:

Ratings and Reviews

About the Serial Editor

Gerald Litwack

Dr. Litwack was formerly Professor of Molecular and Cellular Medicine and Associate Director at the Institute for Regenerative Medicine, Texas A & M Health Science Center.

Affiliations and Expertise

Toluca Lake, North Hollywood, CA, USA