Antioxidants

1st Edition, Volume 121 - January 25, 2023
Editor: Gerald Litwack
Language: English
Hardback ISBN:
9 7 8 - 0 - 4 4 3 - 1 5 7 6 8 - 4
eBook ISBN:
9 7 8 - 0 - 4 4 3 - 1 5 7 6 9 - 1

Antioxidants, Volume 121 in the Vitamins and Hormones series, highlights new advances in the field, with this new volume presenting interesting chapters written by an intern… Read more

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Antioxidants, Volume 121 in the Vitamins and Hormones series, highlights new advances in the field, with this new volume presenting interesting chapters written by an international board of authors.

Cover image
Title page
Table of Contents
Copyright
Former Editors
Contributors
About the editor
Preface
Chapter One: In silico study of natural antioxidants
Abstract
1: Antioxidants
2: Natural antioxidants
3: Computer assisted study of natural antioxidant activities
4: Conclusion and future direction
References
Chapter Two: Hydrogen peroxide detoxification through the peroxiredoxin/thioredoxin antioxidant system: A look at the pancreatic β-cell oxidant defense
Abstract
1: The many roles of ROS in mammalian cells
2: Thioredoxin and thioredoxin reductase
3: Catalytic mechanisms and isoforms of peroxiredoxins
4: Relevance to human disease: Roles of thioredoxin/peroxiredoxin in protecting pancreatic β-cells from oxidative damage
5: Peroxiredoxin-mediated hydrogen peroxide signaling
6: Hydrogen peroxide signaling and β-cell function
Funding
References
Chapter Three: Molecular docking approaches and its significance in assessing the antioxidant properties in different compounds
Abstract
1: Introduction
2: Molecular docking techniques
3: Docking strategies based on the flexibility and rigidity of interacting components
4: Docking studies to evaluate antioxidant activity of compounds
5: Future scope of the work
6: Conclusion
References
Chapter Four: Scavengome of an antioxidant
Abstract
1: Antioxidants and their mechanism of action: Introduction of the scavengome concept
2: Biomimetic oxidative chemistry: Exploring the scavengome
3: Oxidative transformations of selected antioxidants
4: Drug discovery value of the chemical metabolite space of I–IV
5: Summary
Acknowledgments
References
Chapter Five: The antioxidant glutathione
Abstract
1: Introduction
2: Glutathione
3: The many roles of glutathione as an antioxidant
4: S-glutathionylation and role of glutathione in redox regulation
5: Conclusions and future directions
Acknowledgments
References
Chapter Six: Beneficial antioxidant effects of Coenzyme Q10 on reproduction
Abstract
1: Introduction
2: CoQ10 supplementation promotes female reproductive health
3: Potential pharmacologic interactions of CoQ10 supplementation
4: Conclusion
References
Chapter Seven: Antioxidants affect endoplasmic reticulum stress-related diseases
Abstract
1: The endoplasmic reticulum (ER)
2: ER stress and oxidative stress crosstalk
3: Antioxidants and regulation of the UPR
4: Antioxidants and ER stress-related diseases
5: Concluding remarks and future directions
Acknowledgments
References
Chapter Eight: Hormone-linked redox status and its modulation by antioxidants
Abstract
1: Introduction
2: Hormones, redox status, and antioxidant defense system
3: Methods to measure oxidative stress markers and their limitations
4: Hormones triggering oxidative stress and the role of antioxidant supplements
5: Hormones exhibiting antioxidant properties
6: Conclusion
Acknowledgments
References
Chapter Nine: Ascorbic acid as antioxidant
Abstract
1: Introduction
2: Chemical structure and bioavailability
3: Antioxidant properties
4: Ascorbic acid and oxidative modifications
5: Ascorbic acid cooperation with other antioxidants
6: Summary
References
Chapter Ten: Free radicals, antioxidants, nuclear factor-E2-related factor-2 and liver damage
Abstract
1: Liver disease etiology
2: Reactive oxygen species (ROS) in liver health and disease
3: Antioxidants in liver health and disease
4: Oxidative stress, Nrf2 and liver fibrosis
5: Conclusions and future directions
Acknowledgments
Funding
References
Chapter Eleven: Mechanisms of action of vitamin D in delaying aging and preventing disease by inhibiting oxidative stress
Abstract
1: Introduction
2: The effect of 1,25-dihydroxyvitamin D deficiency and 1,25-dihydroxyvitamin D supplementation on aging and age-related diseases and on oxidative stress parameters in studies in animals in vivo and in vitro
3: Mechanisms of action of 1,25-dihydroxyvitamin D in reducing oxidative stress
4: The effect of vitamin D supplementation on aging and age-related diseases and on oxidative stress parameters in humans
5: Controversies of the use of vitamin D supplementation in humans to reduce its anti-oxidant effect and ameliorate age-related disease
Acknowledgments
References
Chapter Twelve: Antioxidant conjugated metal complexes and their medicinal applications
Abstract
1: Introduction
2: Antioxidant conjugated metal complexes
3: Conclusions
Acknowledgments
References
Chapter Thirteen: Natural–product–inspired bioactive alkaloids agglomerated with potential antioxidant activity: Recent advancements on structure-activity relationship studies and future perspectives
Abstract
1: Introduction
2: Mechanism of antioxidant potential and its evaluation methods
3: Structure-activity relationship studies of natural bioactive alkaloids agglomerated with potential antioxidant property
4: Application of antioxidant potential of alkaloids (Table 1)
5: Summary
6: Conclusion
7: Future perspectives
Acknowledgments
Declarations
References
Further reading
Chapter Fourteen: Antioxidants: Structure–activity of plant polyphenolics
Abstract
1: Introduction to polyphenolics
2: Polyphenolics as antioxidants
3: Potent key targets behind antioxidant therapies
4: Structure–activity of plant metabolites
5: Conclusions
Acknowledgments
References
Chapter Fifteen: Protein l-isoAspartyl Methyltransferase (PIMT) and antioxidants in plants
Abstract
1: Introduction
2: Abiotic stress and reactive oxygen species
3: Antioxidants in plants
4: Protein l-isoAspartyl Methyltransferases
5: Role of PIMT in plants
6: PIMT and antioxidants
7: Identification of isoAsp susceptible proteins
8: Conclusion
References

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Gerald Litwack