Antineoplastic Agents
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Cancer and Chemotherapy, Volume III: Antineoplastic Agents is a collection of articles that deals with the treatment of cancer using drugs. The collection describes the various drugs that are used, the therapeutic approaches being taken, and agents that are being developed. Part I is a general review of anti-cancer drugs as regards their action mechanisms, pharmacokinetics, pharmacology, known toxicities, and clinical utility. These drugs include alkylating agents such as mitomycin C and nitrosoureas; plant alkaloids such as maytansine; antibiotics such as anthracyclines; platinum-containing complexes; antimetabolites; and hormones. Part II examines the molecular pharmacology of some major drug classes, namely, bleomycin and anthracycline. The text also discusses the chemistry, mechanism, and any structure-activity relationships found in these drug classes. Part III discusses in detail the clinical pharmacology of some antitumor drugs, for example, cisplatin and nitrosoureas. The text includes the clinical applications, biochemistry, metabolism, and the use of mathematical models in interpreting or describing resulting data. The book is helpful for pharmacologists, molecular biologists, and scientists involved in cancer-research.
Table of Contents
List of Contributors
General Preface
Preface to Volume III
Part I General Reviews
1 Nucleoside Analogues
I. Introduction
II. Cytosine Arabinoside
III. 5-Azacytidin
IV. 5-Fluorouracil
V. Other 5-Fluoro Pyrimidines
VI. 3-Deazauridine
VII. Purine Analogs
VIII. Arabinosyl Adenine
IX. Conclusions
References
2 Cyclophosphamide and Analogues
I. Introduction
II. Structure and Metabolism
III. Clinical Pharmacology
IV. Toxicities
V. Clinical Activity and Dose Schedules
VI. Analogues
References
3 Nitrosoureas
I. Introduction
II. Decomposition and Metabolism
III. Mechanism of Action
IV. Clinical Use
V. Clinical Toxicities
VI. Discussion
References
4 Mitomycin C - An Overview
I. Introduction
II. Chemistry
III. Structure-Activity Relationships
IV. Molecular Pharmacology
V. Pharmacology
VI. Clinical Effects
VII. Conclusions
References
5 Other Alkylating Agents
I. Introduction
II. Mechanism of Action
III. Other Alkylating Agents
IV. Conclusions
References
6 The Vinca Alkaloids and Similar Compounds
I. The Vinca Alkaloids
II. The Podophyllotoxin Derivatives
III. Maytansine
References
7 Bleomycin - An Overview
I. Introduction
II. Chemistry
III. Molecular Pharmacology
IV. Clinical Pharmacology
V. Clinical Activities
VI. Clinical Toxicities
VII. Conclusions
References
8 The Anthracyclines
I. Introduction
II. Chemistry
III. Molecular Pharmacology
IV. Clinical Pharmacology
V. Clinical Activities of Adriamycin and Daunorubicin
VI. Toxicities of Adriamycin
VII. Anthracyclines in Development
References
9 Cisplatin and Analogues: A New Class of Anticancer Drugs
I. Introduction
II. Antitumor Activity in Animal Tumors
III. Animal Toxicology
IV. Efficacy
V. Toxicity
VI. Cisplatin Analogues
VII. Conclusion
References
10 Investigational Cancer Drugs
I. Introduction
II. Alkylating Agents
III. Anthracycline Analogues
IV. Tubulin Binding Agents
V. Antitumor Antibiotics
VI. Nitrosoureas
VII. Antimetabolites
VIII. Miscellaneous
IX. Summary
References
11 Hormone Therapy
I. Basis of Endocrine Therapy
II. Prostatic Cancer
III. Breast Cancer
IV. Cancer of the Uterine Endometrium
V. Lymphomas
VI. Summary
References
12 A Human Tumor Stem Cell System: Concepts, Methodology, and Application
I. Introduction
II. Methodology
III. Applications
IV. Conclusions
References
Part II Molecular Pharmacology of Selected Antineoplastic Agents
13 The Molecular Pharmacology of Bleomycin
I. Introduction
II. Chemistry
III. The Interactions of Metals with Bleomycin and Analogues
IV. Effects of Bleomycin on Isolated DNA
V. Cellular Effects
VI. Effects on the Cell Cycle
VII. Morphological Effects
VIII. Intracellular Fate and Metabolism
IX. Conclusions
References
14 Molecular Pharmacology of Anthracycline Antitumor Antibiotics
I. Introduction
II. Chemistry
III. Studies on the Mechanism of Action of Anthracyclines
IV. Anthracycline Structure-Activity Relationships
V. Conclusions
References
15 Vinca Alkaloids: Molecular and Clinical Pharmacology
I. Introduction
II. Molecular Structure
III. Molecular Pharmacology
IV. Clinical Pharmacology
V. Conclusion
References
16 Molecular Pharmacology of Alkylating Agents
I. Introduction
II. Chemistry of the Alkylating Reactions
III. Clinically Effective Alkylating Agents
IV. Reactions with Biological Molecules
V. Discussion
References
17 Molecular Pharmacology of Cisplatin
I. Introduction
II. Chemistry
III. Biochemistry and Mechanism of Action
IV. Conclusion
References
18 Methotrexate: Molecular Pharmacology
I. Introduction
II. Chemistry
III. Mechanism of Action and Structure-Activity Relationships
IV. Transport of Methotrexate and Related Compounds
V. Mechanisms of Resistance to Folate Antagonists
VI. The Future for Folate Antagonists
References
Part III Clinical Pharmacology of Selected Neoplastic Agents
19 Introduction to Clinical Pharmacology
I. Introduction
II. Pharmacokinetics
III. Mathematical Modeling
IV. Clinical Correlations of Pharmacokinetics
V. Discussion
References
20 Clinical Pharmacology of Bleomycin
I. Introduction
II. Newer Clinical Pharmacological Assays for Bleomycin
III. Absorption
IV. Distribution
V. Elimination
VI. Conclusions
References
21 Clinical Pharmacology of Cisplatin
I. Introduction
II. Cisplatin Pharmacokinetics
III. Cisplatin Stability
IV. Conclusion
References
22 Methotrexate: Clinical Pharmacology and Therapeutic Application
I. Introduction
II. Pharmacology
III. Clinical Applications
IV. Discussion
References
23 Clinical Pharmacology of Nitrosoureas
I. Introduction
II. Molecular Structure
III. Biochemistry and Metabolism
IV. Clinical Pharmacology
V. Discussion
References
Index
Product details
- No. of pages: 414
- Language: English
- Copyright: © Academic Press 1981
- Published: January 1, 1981
- Imprint: Academic Press
- eBook ISBN: 9781483267913