Antineoplastic Agents - 1st Edition - ISBN: 9780121978037, 9781483267913

Antineoplastic Agents

1st Edition

Editors: Stanley T. Crooke Archie W. Prestayko
eBook ISBN: 9781483267913
Imprint: Academic Press
Published Date: 1st January 1981
Page Count: 414
Tax/VAT will be calculated at check-out Price includes VAT (GST)
30% off
30% off
30% off
30% off
30% off
20% off
20% off
30% off
30% off
30% off
30% off
30% off
20% off
20% off
30% off
30% off
30% off
30% off
30% off
20% off
20% off
72.95
51.06
51.06
51.06
51.06
51.06
58.36
58.36
54.95
38.47
38.47
38.47
38.47
38.47
43.96
43.96
43.99
30.79
30.79
30.79
30.79
30.79
35.19
35.19
Unavailable
Price includes VAT (GST)
× DRM-Free

Easy - Download and start reading immediately. There’s no activation process to access eBooks; all eBooks are fully searchable, and enabled for copying, pasting, and printing.

Flexible - Read on multiple operating systems and devices. Easily read eBooks on smart phones, computers, or any eBook readers, including Kindle.

Open - Buy once, receive and download all available eBook formats, including PDF, EPUB, and Mobi (for Kindle).

Institutional Access

Secure Checkout

Personal information is secured with SSL technology.

Free Shipping

Free global shipping
No minimum order.

Description

Cancer and Chemotherapy, Volume III: Antineoplastic Agents is a collection of articles that deals with the treatment of cancer using drugs. The collection describes the various drugs that are used, the therapeutic approaches being taken, and agents that are being developed.
Part I is a general review of anti-cancer drugs as regards their action mechanisms, pharmacokinetics, pharmacology, known toxicities, and clinical utility. These drugs include alkylating agents such as mitomycin C and nitrosoureas; plant alkaloids such as maytansine; antibiotics such as anthracyclines; platinum-containing complexes; antimetabolites; and hormones. Part II examines the molecular pharmacology of some major drug classes, namely, bleomycin and anthracycline. The text also discusses the chemistry, mechanism, and any structure-activity relationships found in these drug classes. Part III discusses in detail the clinical pharmacology of some antitumor drugs, for example, cisplatin and nitrosoureas. The text includes the clinical applications, biochemistry, metabolism, and the use of mathematical models in interpreting or describing resulting data.
The book is helpful for pharmacologists, molecular biologists, and scientists involved in cancer-research.

Table of Contents


List of Contributors

General Preface

Preface to Volume III

Part I General Reviews

1 Nucleoside Analogues

I. Introduction

II. Cytosine Arabinoside

III. 5-Azacytidin

IV. 5-Fluorouracil

V. Other 5-Fluoro Pyrimidines

VI. 3-Deazauridine

VII. Purine Analogs

VIII. Arabinosyl Adenine

IX. Conclusions

References

2 Cyclophosphamide and Analogues

I. Introduction

II. Structure and Metabolism

III. Clinical Pharmacology

IV. Toxicities

V. Clinical Activity and Dose Schedules

VI. Analogues

References

3 Nitrosoureas

I. Introduction

II. Decomposition and Metabolism

III. Mechanism of Action

IV. Clinical Use

V. Clinical Toxicities

VI. Discussion

References

4 Mitomycin C - An Overview

I. Introduction

II. Chemistry

III. Structure-Activity Relationships

IV. Molecular Pharmacology

V. Pharmacology

VI. Clinical Effects

VII. Conclusions

References

5 Other Alkylating Agents

I. Introduction

II. Mechanism of Action

III. Other Alkylating Agents

IV. Conclusions

References

6 The Vinca Alkaloids and Similar Compounds

I. The Vinca Alkaloids

II. The Podophyllotoxin Derivatives

III. Maytansine

References

7 Bleomycin - An Overview

I. Introduction

II. Chemistry

III. Molecular Pharmacology

IV. Clinical Pharmacology

V. Clinical Activities

VI. Clinical Toxicities

VII. Conclusions

References

8 The Anthracyclines

I. Introduction

II. Chemistry

III. Molecular Pharmacology

IV. Clinical Pharmacology

V. Clinical Activities of Adriamycin and Daunorubicin

VI. Toxicities of Adriamycin

VII. Anthracyclines in Development

References

9 Cisplatin and Analogues: A New Class of Anticancer Drugs

I. Introduction

II. Antitumor Activity in Animal Tumors

III. Animal Toxicology

IV. Efficacy

V. Toxicity

VI. Cisplatin Analogues

VII. Conclusion

References

10 Investigational Cancer Drugs

I. Introduction

II. Alkylating Agents

III. Anthracycline Analogues

IV. Tubulin Binding Agents

V. Antitumor Antibiotics

VI. Nitrosoureas

VII. Antimetabolites

VIII. Miscellaneous

IX. Summary

References

11 Hormone Therapy

I. Basis of Endocrine Therapy

II. Prostatic Cancer

III. Breast Cancer

IV. Cancer of the Uterine Endometrium

V. Lymphomas

VI. Summary

References

12 A Human Tumor Stem Cell System: Concepts, Methodology, and Application

I. Introduction

II. Methodology

III. Applications

IV. Conclusions

References

Part II Molecular Pharmacology of Selected Antineoplastic Agents

13 The Molecular Pharmacology of Bleomycin

I. Introduction

II. Chemistry

III. The Interactions of Metals with Bleomycin and Analogues

IV. Effects of Bleomycin on Isolated DNA

V. Cellular Effects

VI. Effects on the Cell Cycle

VII. Morphological Effects

VIII. Intracellular Fate and Metabolism

IX. Conclusions

References

14 Molecular Pharmacology of Anthracycline Antitumor Antibiotics

I. Introduction

II. Chemistry

III. Studies on the Mechanism of Action of Anthracyclines

IV. Anthracycline Structure-Activity Relationships

V. Conclusions

References

15 Vinca Alkaloids: Molecular and Clinical Pharmacology

I. Introduction

II. Molecular Structure

III. Molecular Pharmacology

IV. Clinical Pharmacology

V. Conclusion

References

16 Molecular Pharmacology of Alkylating Agents

I. Introduction

II. Chemistry of the Alkylating Reactions

III. Clinically Effective Alkylating Agents

IV. Reactions with Biological Molecules

V. Discussion

References

17 Molecular Pharmacology of Cisplatin

I. Introduction

II. Chemistry

III. Biochemistry and Mechanism of Action

IV. Conclusion

References

18 Methotrexate: Molecular Pharmacology

I. Introduction

II. Chemistry

III. Mechanism of Action and Structure-Activity Relationships

IV. Transport of Methotrexate and Related Compounds

V. Mechanisms of Resistance to Folate Antagonists

VI. The Future for Folate Antagonists

References

Part III Clinical Pharmacology of Selected Neoplastic Agents

19 Introduction to Clinical Pharmacology

I. Introduction

II. Pharmacokinetics

III. Mathematical Modeling

IV. Clinical Correlations of Pharmacokinetics

V. Discussion

References

20 Clinical Pharmacology of Bleomycin

I. Introduction

II. Newer Clinical Pharmacological Assays for Bleomycin

III. Absorption

IV. Distribution

V. Elimination

VI. Conclusions

References

21 Clinical Pharmacology of Cisplatin

I. Introduction

II. Cisplatin Pharmacokinetics

III. Cisplatin Stability

IV. Conclusion

References

22 Methotrexate: Clinical Pharmacology and Therapeutic Application

I. Introduction

II. Pharmacology

III. Clinical Applications

IV. Discussion

References

23 Clinical Pharmacology of Nitrosoureas

I. Introduction

II. Molecular Structure

III. Biochemistry and Metabolism

IV. Clinical Pharmacology

V. Discussion

References

Index

Details

No. of pages:
414
Language:
English
Copyright:
© Academic Press 1981
Published:
Imprint:
Academic Press
eBook ISBN:
9781483267913

About the Editor

Stanley T. Crooke

Archie W. Prestayko