COVID-19 Update: We are currently shipping orders daily. However, due to transit disruptions in some geographies, deliveries may be delayed. To provide all customers with timely access to content, we are offering 50% off Science and Technology Print & eBook bundle options. Terms & conditions.
Antimicrobial Resistance and Food Safety - 1st Edition - ISBN: 9780128012147, 9780128013373

Antimicrobial Resistance and Food Safety

1st Edition

Methods and Techniques

Editors: Chin-Yi Chen Xianghe Yan Charlene R. Jackson
Hardcover ISBN: 9780128012147
eBook ISBN: 9780128013373
Imprint: Academic Press
Published Date: 21st April 2015
Page Count: 452
Sales tax will be calculated at check-out Price includes VAT/GST
Price includes VAT/GST

Institutional Subscription

Secure Checkout

Personal information is secured with SSL technology.

Free Shipping

Free global shipping
No minimum order.


Antimicrobial Resistance and Food Safety: Methods and Techniques introduces antimicrobial resistant food-borne pathogens, their surveillance and epidemiology, emerging resistance and resistant pathogens. This analysis is followed by a systematic presentation of currently applied methodology and technology, including advanced technologies for detection, intervention, and information technologies. This reference can be used as a practical guide for scientists, food engineers, and regulatory personnel as well as students in food safety, food microbiology, or food science.

Key Features

  • Includes analysis of all major pathogens of concern
  • Provides many case studies and examples of fundamental research findings
  • Presents recent advances in methodologies and analytical software
  • Demonstrates risk assessment using information technologies in foodborne pathogens


Research Biologists, Microbiologists, Researchers in government, and product development managers as well as their allied industries

Table of Contents

Chapter 1. Introduction to Antimicrobial-Resistant Foodborne Pathogens

  • How Antimicrobial Resistance Is Defined?
  • How Does Resistance Spread Between Ecosystems?
  • Conclusion
  • References

Chapter 2. Antimicrobial Resistance of Shiga Toxin-Producing Escherichia coli

  • Introduction
  • Resistance of E. coli O157:H7 to Antibiotics
  • Resistance of E. coli O157:H7 and Other STEC to Antimicrobial Interventions
  • Conclusion
  • References

Chapter 3. Antibiotic Resistance in Pathogenic Salmonella

  • Introduction
  • Salmonella spp. as a Pathogen
  • Pathogenesis of Salmonella
  • Salmonella and Antibiotics
  • Factors that Influence Salmonella Antibiotic Resistance
  • Conclusions
  • References

Chapter 4. Antimicrobial Resistance and Campylobacter jejuni and C. coli

  • Introduction
  • Resistance Mechanisms
  • Development of Resistance
  • Genetic Adaptive Mechanisms in Resistant Bacteria
  • Consequences of Resistance on Bacterial Fitness
  • Resistance Detection
  • Genetic Methods in the Detection of Resistance Determining Targets
  • Genomic Analysis of Resistance
  • Clinical Breakpoints and Epidemiological Cut-Off Values
  • References

Chapter 5. Antimicrobial Resistance in Yersinia enterocolitica

  • Introduction
  • Antimicrobial Susceptibility
  • Mechanisms of Antimicrobial Resistance
  • Concluding Remarks
  • References

Chapter 6. Antimicrobial Resistance in Vibrio Species

  • Introduction
  • Epidemiology and Underreporting
  • Data Limitations and Emerging Methods for Assessing Antibiotic Resistance
  • Conclusions
  • References

Chapter 7. Antimicrobial Resistance in Shigella Species

  • Introduction
  • Antibiotic Resistance
  • North America
  • South America
  • Europe
  • Africa
  • Asia
  • Final Thoughts
  • References

Chapter 8. Antimicrobial Resistance in Listeria spp.

  • Introduction
  • Mechanisms of Antibiotic Resistance
  • Relationship of Antimicrobial Resistance to Virulence
  • Selection for Resistant Phenotypes
  • Relevance to Food Safety and Public Health
  • Conclusions
  • Acknowledgments
  • References

Chapter 9. Antibiotic Resistance in Enterococci: A Food Safety Perspective

  • General Introduction
  • Taxonomy and Characteristics
  • Status as Probiotics
  • Clinical Status
  • Food Animals as a Reservoir of Antibiotic-Resistant Strains
  • Farm Environment and Antibiotic-Resistant Strains
  • Status as Food Contaminants
  • Sharing of Enterococcal Strains Among Food Animals, Food, and Humans
  • Other Important Links
  • Concluding Remarks
  • References

Chapter 10. Clostridium difficile: A Food Safety Concern?

  • Introduction
  • Pathogenesis
  • Epidemiology
  • Food Animals and Food
  • Conclusions
  • References

Chapter 11. Methods for the Detection of Antimicrobial Resistance and the Characterization of Staphylococcus aureus Isolates from Food-Producing Animals and Food of Animal Origin

  • Introduction
  • Detection and Analysis of Antimicrobial Resistance in S. aureus
  • Typing of S. aureus
  • Detection of Virulence Genes in S. aureus
  • Examples for the Complex Characterization of S. aureus from Food-Producing Animals and Food of Animal Sources
  • Conclusions
  • Acknowledgments
  • References

Chapter 12. Non-Phenotypic Tests to Detect and Characterize Antibiotic Resistance Mechanisms in Enterobacteriaceae

  • Endpoint PCRs
  • Real-Time PCRs
  • Microarray
  • Next-Generation DNA-Sequencing Methodologies
  • Mass Spectrometry-Based Methodologies
  • Conclusions
  • References

Chapter 13. Monitoring and Surveillance: The National Antimicrobial Resistance Monitoring System

  • Introduction
  • NARMS Overview
  • Drug Selection and Breakpoints Used
  • Current  Testing Methods
  • The Evolution of NARMS
  • Data Acquisition and Reporting
  • International Harmonization
  • NARMS in Action—Public Health Impact
  • Strengths and Limitations
  • Conclusion
  • References

Chapter 14. Risk Assessment of Antimicrobial Resistance

  • Introduction
  • Risk Assessment
  • Antimicrobial Resistance Risk Assessment
  • Mathematical and Other Risk Analytical Approaches
  • Acknowledgment
  • References

Chapter 15. Food Microbial Safety and Animal Antibiotics

  • Introduction
  • Methods of QRA
  • Attribution-Based Risk Assessment and Controversies
  • Empirical Upper-Bounding
  • Managing Uncertain Food Risks via Quality Principles: HACCP
  • Discussion and Conclusions
  • References

Chapter 16. Antibiotic-Resistant Bacteria and Resistance Genes in the Water–Food Nexus of the Agricultural Environment

  • Introduction
  • Methods to Determine Antibiotic-Resistant Bacteria and Resistance Genes
  • Past Monitoring Surveys—Detailing the Knowledge Gaps
  • Impact on Soils, Crops, and Health
  • Quantitative Microbial Risk Assessment
  • Technological Solutions
  • Conclusions
  • References

Chapter 17. Development and Application of Novel Antimicrobials in Food and Food Processing

  • Introduction—Why Novel Antimicrobials Are Needed
  • Essential Oils
  • Chitosan
  • Antimicrobial Peptides
  • Bacteriophage
  • Natural Antimicrobial Combinations
  • Synergistic Activity of Novel Antimicrobials and Novel Technology
  • Considerations When Selecting Novel Antimicrobials
  • Conclusion and Future Trends
  • References

Chapter 18. Database Resources Dedicated to Antimicrobial Peptides

  • Introduction
  • General Databases for AMPs
  • Specialized Databases for AMPs
  • Websites Dedicated to AMP Prediction
  • Database-Based Peptide Design
  • Concluding Remarks
  • Acknowledgments
  • References

Chapter 19. Metabolic Network Analysis-Based Identification of Antimicrobial Drug Target in Pathogenic Bacteria

  • Introduction
  • Background
  • Metabolic Target Identification of Staphylococcus aureus
  • Metabolic Targets in Bacillus anthracis
  • Metabolic Targets in Francisella tularensis
  • Metabolic Targets in Yersinia pestis
  • Target to Hit Molecule Generation
  • Conclusion
  • References

Chapter 20. Application of Metagenomic Technologies for Antimicrobial Resistance and Food Safety Research and Beyond

  • Introduction
  • Meta-Omic Workflow
  • Examples of Metagenomic Research
  • Challenges and Future Outlook
  • Acknowledgment
  • References


No. of pages:
© Academic Press 2015
21st April 2015
Academic Press
Hardcover ISBN:
eBook ISBN:

About the Editors

Chin-Yi Chen

Chin-Yi Chen, Ph.D.

Research Molecular Biologist

Molecular Characterization of Foodborne Pathogens RU


600 E. Mermaid Ln.

Wyndmoor, PA 19038

TEL: 215-233-6526

FAX: 215-233-6581

Affiliations and Expertise


Xianghe Yan

Xianghe Yan, Ph.D.

Computational Biologist

Molecular Characterization of Foodborne Pathogens RU


600 E. Mermaid Lane

Wyndmoor, PA 19038

Affiliations and Expertise


Charlene R. Jackson

Charlene R. Jackson, Ph.D.

Microbiologist, Senior Research Scientist

Bacterial Epidemiology and Antimicrobial Resistance Research Unit

USDA-ARS, Russell Research Center

Athens, GA 30605

Affiliations and Expertise

USDA-ARS, Russell Research Center, Athens, GA, USA

Ratings and Reviews