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Medicinal Chemistry: A Series of Monographs, Volume 15: Anticonvulsants discusses the laboratory evaluation, drug disposition, clinical evaluation, and synthesis and design of anticonvulsant drugs.
This book is organized into eight chapters. Chapters 1 and 2 provide an overview and neuropharmacological background of anticonvulsants. The laboratory evaluation of compounds is described in Chapter 3, while drug disposition is treated in Chapter 4. The chemistry and biological activities of the various classes of anticonvulsant compounds, such as cyclic ureides, benzopyrans, heterocyclic drugs, and noncyclic anticonvulsants are presented in Chapters 5 to 8.
This volume is written specifically for medicinal chemists, biochemists, neurologists, and pharmacologists.
List of Contributors
1 Advances in Anticonvulsant Drug Development
2 Neuropharmacology and Treatment of Epilepsy
II. Classification of Seizures
IV. Neuro Physiology
V. Mechanism of Anticonvulsant Drug Action
VI. Therapeutic Use of Anticonvulsant Drugs
3 Experimental Evaluation of Anticonvulsants
IV. Barbiturates and Related Compounds
VIII. Miscellaneous Anticonvulsants
4 Physiological Disposition of Anticonvulsants
II. Diphenylhydantoin and Other Hydantoins
III. The Barbiturates
V. The Succinimides
VI. The Oxazolidinediones
IX. The Benzodiazepines
5 Cyclic Ureides
I. The Cyclic Ureide Structure
IX. Addendum: Tables (1-62)
III. Anticonvulsant Properties
7 Other Heterocyclic Drugs
I. Small-Ring Compounds
II. Five-Membered Rings
III. Six-Membered Rings
IV. Seven-Membered and Larger Rings (Except for Diazepines)
V. Diazepines and Related Compounds
8 Noncyclic Anticonvulsants
II. Urea Derivatives
IV. Carboxylic Acids and Amides
VII. Structure-Activity Relationships
- No. of pages:
- © Academic Press 1977
- 1st January 1977
- Academic Press
- eBook ISBN: