1st Edition - January 1, 1977

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  • Editor: Julius Vida
  • eBook ISBN: 9780323143950

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Medicinal Chemistry: A Series of Monographs, Volume 15: Anticonvulsants discusses the laboratory evaluation, drug disposition, clinical evaluation, and synthesis and design of anticonvulsant drugs. This book is organized into eight chapters. Chapters 1 and 2 provide an overview and neuropharmacological background of anticonvulsants. The laboratory evaluation of compounds is described in Chapter 3, while drug disposition is treated in Chapter 4. The chemistry and biological activities of the various classes of anticonvulsant compounds, such as cyclic ureides, benzopyrans, heterocyclic drugs, and noncyclic anticonvulsants are presented in Chapters 5 to 8. This volume is written specifically for medicinal chemists, biochemists, neurologists, and pharmacologists.

Table of Contents

  • List of Contributors


    1 Advances in Anticonvulsant Drug Development



    2 Neuropharmacology and Treatment of Epilepsy

    I. Introduction

    II. Classification of Seizures

    III. Neurochemistry

    IV. Neuro Physiology

    V. Mechanism of Anticonvulsant Drug Action

    VI. Therapeutic Use of Anticonvulsant Drugs


    3 Experimental Evaluation of Anticonvulsants

    I. Introduction

    II. Methods

    III. Hydantoins

    IV. Barbiturates and Related Compounds

    V. Oxazolidinediones

    VI. Succinimides

    VII. Benzodiazepines

    VIII. Miscellaneous Anticonvulsants


    4 Physiological Disposition of Anticonvulsants

    I. Introduction

    II. Diphenylhydantoin and Other Hydantoins

    III. The Barbiturates

    IV. Primidone

    V. The Succinimides

    VI. The Oxazolidinediones

    VII. Acetylureas

    VIII. Carbamazepine

    IX. The Benzodiazepines

    X. Acetazolamide

    XI. Sulthiame


    5 Cyclic Ureides

    I. The Cyclic Ureide Structure

    II. Barbiturates

    III. Eterobarb

    IV. Primidone

    V. Hydantoins

    VI. Doxenitoine

    VII. Oxazolidinediones

    VIII. Succinimides

    IX. Addendum: Tables (1-62)


    6 Benzopyrans

    I. Introduction

    II. Chemistry

    III. Anticonvulsant Properties

    IV. Discussion


    7 Other Heterocyclic Drugs

    I. Small-Ring Compounds

    II. Five-Membered Rings

    III. Six-Membered Rings

    IV. Seven-Membered and Larger Rings (Except for Diazepines)

    V. Diazepines and Related Compounds


    8 Noncyclic Anticonvulsants

    I. General

    II. Urea Derivatives

    III. Carbamates

    IV. Carboxylic Acids and Amides

    V. Sulfonamides

    VI. Hydrazones

    VII. Structure-Activity Relationships


    Subject Index

Product details

  • No. of pages: 652
  • Language: English
  • Copyright: © Academic Press 1977
  • Published: January 1, 1977
  • Imprint: Academic Press
  • eBook ISBN: 9780323143950

About the Editor

Julius Vida

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