Antibiotic-Producing Stetomyces

Antibiotic-Producing Stetomyces

1st Edition - March 28, 1986

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  • Editor: Stephen W. Queener
  • eBook ISBN: 9780323162937

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The Bacteria: Volume IX: Antibiotic-Producing Streptomyces explores how Streptomyces, including actinomycetes, produce a variety of antibiotics such as aminocyclitols, ansamycins, macrolides, and tetracyclines. Topics covered range from physiology and fermentation to genetic recombination and chromosome mapping in Streptomyces, biomodification of antibiotics by Streptomyces, and biosynthesis of tylosin and erythromycin. The genome structure and evolution of Streptomyces are also discussed. This volume is comprised of 10 chapters and begins with a discussion on the taxonomy of Streptomyces based on morphology, physiological characteristics, the composition of cell constituents such as cell walls, and the presence of characteristic lipids, sugars, and quinones. The discussion then turns to the intraspecific and interspecific recombination in Streptomyces; pathways of DNA repair and mutagenesis in Streptomyces fradiae; strategies for isolation of improved Streptomyces mutants for antibiotic production; and derivation of DNA cloning vectors from Streptomyces phages. The biology and use of Streptomyces plasmids as cloning vectors are also described. The final chapter is devoted to major structural classes of antibiotics produced by Streptomyces, including anthracyclines and other quinones, β-lactams, macrolides, nucleosides, peptides, polyenes, polyether antibiotics, and tetracyclines. This book will be of value to microbiologists, bacteriologists, biochemists, and biologists.

Table of Contents

  • Contributors to Volume IX


    Contents of Volumes VI-VIII


    1. Structure and Taxonomy of Streptomyces

    I. Introduction

    II. Characterization of Streptomyces and Related Genera

    III. Morphology of Members of the Family Streptomycetaceae

    IV. Descriptions of Streptomyces and Related Genera in Publications

    V. Use of Characterization Information in Speciation


    2. Genetic Recombination and Maps for Streptomyces

    I. Introduction

    II. Intraspecific Recombination

    III. Interspecific Recombination

    IV. Chromosome Mapping

    V. Discussion


    3. Mutationin Streptomyces

    I. Introduction

    II. Genome Structure and Evolution

    III. Spontaneous Mutations and Genetic Instability

    IV. Induced Mutation

    V. Pathways of DNA Repair and Mutagenesis in Streptomyces fradiae

    VI. Mutagenesis and Strain Development

    VII. Summary and Prospects


    4. Isolation of Streptomyces Mutants Improved for Antibiotic Production

    I. Introduction

    II. The Genetic Basis of Strain Improvement Methods

    III. Theoretical Considerations of Screening Techniques

    IV. Screening Strategies

    V. Genetic Recombination in Strain Improvement

    VI. Genetic Engineering in Strain Improvement

    VII. Conclusions


    5. Streptomyces Phages and Their Applications to Streptomyces Genetics

    I. Introduction

    II. The Temperate Phage ΦC31

    III. Transfection

    IV. The Derivation of DNA Cloning Vectors from Streptomyces Phages

    V. In Vivo Insertions into Phage DNA

    VI. Transcription of Phage DNA In Vitro

    VII. Studies of the Temperate Phage R4

    VIII. Studies of the Temperate Phage SH10

    IX. Transduction and Temperate Phages with Terminally Redundant DNA

    X. Interactions of Phages with Restriction Systems

    XI. Concluding Remarks


    6. Streptomyces Plasmids: Their Biology and Use as Cloning Vectors

    I. Introduction

    II. Methods for Plasmid Detection in Streptomyces

    III. The Occurrence and Variety of Streptomyces Plasmids

    IV. The Biology of Streptomyces Plasmids

    V. Streptomyces Plasmids as Cloning Vectors

    VI. Conclusion


    7. The Biosynthesis of Tylosin and Erythromycin: Model Systems for Studies of the Genetics and Biochemistry of Antibiotic Formation

    I. General Introduction

    II. Tylosin

    III. Erythromycin

    IV. Future Prospects


    8. Physiology and Fermentation Development

    I. Introduction

    II. Nutrient Effects on Cell Growth and Antibiotic Production

    III. Effect of Temperature

    IV. Effects of pH

    V. Agitation and Oxygen Transfer

    VI. CO2

    VII. Growth Morphology

    VIII. Rheology of Fermentation Broths


    9. Biomodification of Antibiotics by Streptomyces

    I. Introduction

    II. Direct Transformations

    III. Indirect Transformations


    10. Antibiotics Produced by Streptomyces: Major Structural Classes

    I. Introduction

    II. Aminocyclitols

    III. Ansamycins

    IV. Anthracyclines and Other Quinones

    V. β-Lactams

    VI. Macrolides

    VII. Nucleosides

    VIII. Peptides

    IX. Polyenes

    X. Polyether Antibiotics

    XI. Tetracyclines

    XII. Miscellaneous



Product details

  • No. of pages: 440
  • Language: English
  • Copyright: © Academic Press 1986
  • Published: March 28, 1986
  • Imprint: Academic Press
  • eBook ISBN: 9780323162937

About the Editor

Stephen W. Queener

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