Anti-Aging Pharmacology

Anti-Aging Pharmacology

1st Edition - December 1, 2022

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  • Editors: Alexander Vaiserman, Vitaly Koltover
  • Paperback ISBN: 9780128236796

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Description

Anti-Aging Pharmacology provides an overview of current research aimed at the pharmacological modulation of aging, including a discussion of the growing number of novel drug classes with promising anti-aging potential. The aging process is the main risk factor for all chronic diseases affecting the elderly. With lifespans extending across the globe, these chronic diseases are placing a larger burden on individuals and health care systems. Therefore, slowing down the aging rate could be more effective in delaying aging-associated chronic disorders than combating them one by one, which is the conventional approach in a current disease-based pharmacological paradigm. This book contains the work of the world’s leading researchers in the field, including sections on the conceptual and methodological background of anti-aging pharmacology, the basic classes of anti-aging drugs, phytochemicals, outcomes of anti-aging developments and future directions. This book will be of interest to a wide audience, ranging from pharmacologists, medicinal chemists and academic researchers in gerontology, biomedical sciences and those in medical practice.

Key Features

  • Includes updated information about current developments in anti-aging pharmacology
  • Offers practical advice on the applicability of certain healthspan-promoting medications
  • Discusses potential challenges related to the translation of anti-aging drugs in clinical practice

Readership

Pharmacologists, medicinal chemists, clinicians, biogerontological researchers, geriatricians

Table of Contents

  • SECTION I. Conceptual and Methodological Backgrounds
    1. Can Aging be Cured as a Disease?
    2. Geroscience Conceipt
    3. Mechanistic Pathways of Aging
    4. Biomarkers of Aging Rate
    5. Artificial Intelligence-Based Approach in Anti-Aging Pharmacology
    6. Big Data Approach
    7. OMICs Approaches

    SECTION II. Basic Classes of Anti-Aging Drugs
    8. Antioxidant Paradox
    9. Melatonin
    10. Calorie Restriction Mimetics
    11. Metformin
    12. Rapamycin and rapalogs
    13. Nonsteroidal Anti-Inflammatory Drugs
    14. Statins
    15. Senolytics
    16. Epigenetic Drugs
    17. Sirtuin Activating Compounds
    18. Autophagy Inducers
    19. Mitophagy Modulators
    20. Telomerase Activators

    SECTION III. Phytochemicals
    21. Resveratrol
    22. Curcumin
    23. Quercetin
    24. Genistein
    25. Epigallocatechin Gallate
    26. Berberine
    27. Nanodelivery of phytobioactive compounds: a promise in anti-aging medicine

    SECTION IV. Outcomes and Concluding Thoughts
    28. Ethical perspectives on advances in biogerontology
    29. Implications for Public Health Policy
    30. The Business of Anti-Aging Science

Product details

  • No. of pages: 398
  • Language: English
  • Copyright: © Academic Press 2022
  • Published: December 1, 2022
  • Imprint: Academic Press
  • Paperback ISBN: 9780128236796

About the Editors

Alexander Vaiserman

Dr. Vaiserman is head of the Laboratory of Epigenetics at the Institute of Gerontology, where his research has focused on long-term health consequences of adverse conditions in early life, genetic and epigenetic mechanisms of age-associated diseases, telomere length in patients with age-related chronic diseases, and molecular mechanisms mediating lifespan in Drosophila. He earned his PhD from the Institute of Gerontology, Kiev, Ukraine in 2004. During the last 7 years, Dr. Vaiserman was Project Leader for several Ukrainian government sponsored research projects. Dr. Vaiserman is also a member of the editorial boards of the journals Biogerontology, Frontiers in Genetics of Aging, and Gerontology & Geriatric Research. To-date, he has published four book chapters, as well as 65 papers in peer reviewed journals.

Affiliations and Expertise

Head of the Laboratory of Epigenetics, Institute of Gerontology, Kiev, Ukraine

Vitaly Koltover

Vitaly K. Koltover D. Sci. (Biology - Biological Physics), Ph. D. (Physics & Mathematics - Chemical Physics) works as the chief researcher in Department of Kinetics of Chemical and Biological Processes, Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russia (http://www.icp.ac.ru). Graduated Taras Shevchenko University in Kiev, Ukraine, (former SU), Holds PhD in Physics and Mathematics (Chemical Physics), and SciD in Biology (Biological Physics). As invited scientist, visited Austria (Institute of Pharmacology and Toxicology, Vienna); Germany (Max-Planck Institute for Demographic Research, Rostock and Albert-Ludwig University, Freiburg); India (Indian Institute of Technology, Chennai and Bhabha Atomic Center, Mumbai); Israel (Shamoon College of Engineering, Beer Sheva), USA (National Lawrence Laboratory in Berkeley, University of Pennsylvania in Philadelphia, Northwestern University in Evanston). Presented plenary lectures and oral presentations at the scientific meetings in Russia, Austria, Canada, China, France, Greece, India, Italy, Israel, Japan, Ukraine, and USA. Published more than 300 scientific papers, including books, conference proceedings and papers in the representative journals. Main research interests, at the present time, are reliability (robustness) and aging of biological systems, free radicals and antioxidants, magnetic isotopes and nuclear spin catalysis in living systems.

Affiliations and Expertise

Chief Researcher (Principal Investigator), Kinetics of Chemical and Biological Processes, Institute of Problems of Chemical Physics, Russian Academy of Sciences, Chernogolovka, Moscow Region, Russian Federation

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