Description

Annual Reports in Medicinal Chemistry provides timely and critical reviews of important topics in medicinal chemistry together with an emphasis on emerging topics in the biological sciences, which are expected to provide the basis for entirely new future therapies. Sections I-IV are disease orientated and generally report on specific medicinal agents. Sections V and VI continue to emphasize important topics in medicinal chemistry, biology, and drug design. Section VII looks at Trends and Perspectives in the pharmaceuticals market.

Key Features

* Critical reviews of the previous year's literature in many topics of interest to medicinal chemists * Highlights major developments in medicinal chemistry * Includes a comprehensive set of cumulative indices to easily locate topics in all published volumes

Readership

For medicinal, pharmaceutical and organic chemists

Table of Contents

Contributors

Preface

Novel Approaches for the Treatment of Schizophrenia

1 Introduction

2 Approaches targeting altered NMDA receptor function

3 Approaches primarily targeting cognition

4 Approaches primarily targeting psychosis

5 Emerging mechanisms and conclusions

Recent Strategies for the Development of New Antidepressant Drugs

1 Introduction

2 Monoamine reuptake inhibitors

3 SSRIs with monoaminergic receptor modulation

4 Serotonergic receptor modulation

5 Neuropeptide receptor modulation

6 Conclusion

Neuroprotective Agents for the Treatment of Ischemic and Hemorrhagic Stroke

1 Introduction

2 Conclusion

Novel Sodium Channel Blockers for the Treatment of Neuropathic Pain

1 Introduction

2 Background

3 Biological target validation

4 Discovery of novel small molecule blockers

5 Conclusions

Centrally Acting Anti-Obesity Agents

1 Introduction

2 CB1R Antagonists

3 Neuropeptide receptor modulators

4 Aminergic receptor modulators

5 Monoamine re-uptake inhibitors

6 Conclusions

Nuclear Hormone Receptor Modulators for the Treatment of Diabetes and Dyslipidemia

1 Introduction

2 PPARs

3 RXR modulators

4 LXR

5 FXR

6 Conclusion

11β-Hydroxysteroid Dehydrogenase Type 1 Inhibitors

1 Introduction

2 11β-HSD Isozymes

3 Potential therapeutic indications

4 11β-HSD1 Inhibitors

5 Conclusion

Glucokinase Activators for the Treatment of Type 2 Diabetes

1 Introduction

2 Biology of glucokinase

3 Small-molecule glucokinase activators

4 Conclusion and outlook

Renin Inhibitors

1 Introduction

2 Biology

3 Classical renin inhibitors

4 Aliskiren

5 Piperidines

6 Pi

Details

No. of pages:
556
Language:
English
Copyright:
© 2006
Published:
Imprint:
Academic Press
Electronic ISBN:
9780080467412
Print ISBN:
9780120405411