Animal Models of Molecular Pathology

Animal Models of Molecular Pathology

1st Edition - November 26, 2011

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  • Editor: P. Michael Conn
  • Hardcover ISBN: 9780123945969
  • eBook ISBN: 9780123948311

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This volume explores some of the most exciting recent advances in basic research on animal models of molecular pathology.

Key Features

  • This series provides a forum for discussion of new discoveries, approaches, and ideas
  • Contributions from leading scholars and industry experts
  • Reference guide for researchers involved in molecular biology and related fields


Researchers, professors and graduate students in biochemistry, chemistry, molecular biology, biotechnology, and medicine.

Table of Contents

  • Contributors


    Animal Models of Atherosclerosis

    I. Atherosclerosis Development: Basic Concepts

    II. Animal Models of Atherosclerosis

    III. Concluding Remarks


    Genetic Animal Models of Cerebral Vasculopathies

    I. Cerebral Amyloid Angiopathy

    II. Cerebral Autosomal Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL)

    III. Concluding Remarks


    Experimental Models of Seizures and Epilepsies

    I. Introduction

    II. Classification of Epileptic Seizures

    III. Classification of Epileptic Syndromes

    IV. Models for Seizures and Epilepsies

    V. Summary

    Animal Models of Muscular Dystrophy

    I. Dystrophin

    II. The Sarcoglycans

    III. Calcium and Dystrophic Pathology

    IV. α-Actinin

    V. Fukutin-Related Protein and Dystroglycan Processing

    VI. Desmin

    VII. Laminin α2

    VIII. Collagen VI

    IX. D4Z4 Repeats and FSHD

    X. DMPK and Myotonic Dystrophy

    XI. Conclusions


    Acute Phase Proteins in Animals

    I. The Acute Phase Response

    II. Acute Phase Proteins

    III. Clinical Value of APP

    IV. APP in Animals

    V. Concluding Remarks

    Animal Models of Hemophilia

    I. The Hemophilia A Mice

    II. The Hemophilia B Mouse Model

    III. The Hemophilia A and B Dogs

    Animal Models of Lung Cancer

    I. Lung Adenomas and Adenocarcinomas

    II. Lung Squamous Cell Carcinoma

    III. Lung Small Cell Carcinoma

    IV. Chemopreventive Applications in Preclinical Lung Cancer Models

    V. Conclusion

    Cardiovascular Magnetic Resonance Imaging in Small Animals

    I. Introduction

    II. Principals of MRI

    III. MRI Systems for Preclinical Imaging and Experimental Setup

    IV. Cardiovascular MRI

    V. Conclusion

    Animal Models of Inflammatory Bowel Disease

    I. Classification of Murine IBD Models

    II. IL-10 KO Mice

    III. IL-2 KO Mice

    IV. TCRα KO Mice

    V. TGFβ KO Mice

    VI. TAK1 KO Mice

    VII. WASP KO Mice

    VIII. P110δ Mutant Mice

    IX. PDK1 KO Mice

    X. Cbl-b KO Mice

    XI. Blimp-1 KO Mice

    XII. A20 KO Mice

    XIII. SHIP KO Mice

    XIV. Gαi2 KO Mice

    XV. TNF(ARE) Mice

    XVI. LIGHT Tg Mice

    XVII. TNFSF15 Tg Mice

    XVIII. IL-7 Tg Mice

    XIX. IL-15 Tg Mice

    XX. CD40L Tg Mice

    XXI. Soluble B7.2 Tg Mice

    XXII. Integrin αV KO Mice

    XXIII. Integrin β8 KO Mice

    XXIV. STAT4 Tg Mice

    XXV. STAT3 KO Mice

    XXVI. SOCS1 Tg Mice

    XXVII. Gp130 KI Mice

    XXVIII. NFκB1 KO Mice

    XXIX. Runx3 KO Mice

    XXX. TLR5 KO Mice

    XXXI. Enteric Glia KO

    XXXII. XBP1 KO Mice

    XXXIII. Atg5 KO Mice

    XXXIV. mK8 KO Mice

    XXXV. N-Cadherin Mutant Mice

    XXXVI. Mdr1a KO Mice


    XXXVIII. Muc2 KO Mice

    XXXIX. C1galt1 KO Mice

    XL. NFATc2/RAG DKO Mice

    XLI. T-bet/RAG DKO Mice

    XLII. Anti-CD40mAb Model

    XLIII. C3H/HeJBir Mice

    XLIV. SAMP1/Yit Model

    XLV. CD45RB Model

    XLVI. Human CD3ε Model

    XLVII. CD8-Transfer Models


    XLIX. TNBS Model

    L. Oxazolone Model

    LI. DSS Model

    LII. Conclusion


    Animal Models of Molecular Pathology

    I. Murine Models of Lupus

    II. Role of the Major Histocompatibility Complex

    III. Role of Cell Signaling

    IV. Role of Sex Hormones

    V. Role of Cytokines

    VI. Tolerance Models

    VII. Therapies

    VIII. Conclusions

    Animal Models of Cutaneous and Hepatic Fibrosis

    I. Liver Fibrosis

    II. Skin Fibrosis and Scleroderma

    Animal Models of Schizophrenia

    I. Introduction

    II. The Schizophrenia Phenotype

    III. Existing Animal Models for Schizophrenia

    IV. An Example in Progress: A Psychosis Animal Model for Schizophrenia with High Construct Validity

    V. Future Directions for Schizophrenia Models

Product details

  • No. of pages: 472
  • Language: English
  • Copyright: © Academic Press 2011
  • Published: November 26, 2011
  • Imprint: Academic Press
  • Hardcover ISBN: 9780123945969
  • eBook ISBN: 9780123948311

About the Editor

P. Michael Conn

P. Michael Conn is the Senior Vice President for Research and Associate Provost, Texas Tech Health Sciences Center. He is The Robert C. Kimbrough, Professor of Internal Medicine and Cell Biology/Biochemistry. He was previously Director of Research Advocacy and Professor of Physiology and Pharmacology, Cell Biology and Development and Obstetrics and Gynecology at Oregon Health and Science University and Senior Scientist of the Oregon National Primate Research Center (ONPRC). He served for twelve years as Special Assistant to the President and Associate Director of the ONPRC. After receiving a B.S. degree and teaching certification from the University of Michigan (1971), a M.S. from North Carolina State University (1973), and a Ph.D. degree from Baylor College of Medicine (1976), Conn did a fellowship at the NIH, then joined the faculty in the Department of Pharmacology, Duke University Medical Center where he was promoted to Associate Professor in 1982. In 1984, he became Professor and Head of Pharmacology at the University of Iowa College of Medicine, a position he held for eleven years. Conn is known for his research in the area of the cellular and molecular basis of action of gonadotropin releasing hormone action in the pituitary and therapeutic approaches that restore misfolded proteins to function. His work has led to drugs that have benefitted humans and animals. Most recently, he has identified a new class of drugs, pharmacoperones, which act by regulating the intracellular trafficking of receptors, enzymes and ion channels. He has authored or co-authored over 350 publications in this area and written or edited over 200 books, including texts in neurosciences, molecular biology and endocrinology. Conn has served as the editor of many professional journals and book series (Endocrinology, Journal of Clinical Endocrinology and Metabolism, Endocrine, Methods, Progress in Molecular Biology and Translational Science and Contemporary Endocrinology). Conn served on the National Board of Medical Examiners, including two years as chairman of the reproduction and endocrinology committee. The work of his laboratory has been recognized with a MERIT award from the NIH, the J.J. Abel Award of the American Society for Pharmacology and Experimental Therapeutics, the Weitzman, Oppenheimer and Ingbar Awards of the Endocrine Society, the National Science Medal of Mexico (the Miguel Aleman Prize) and the Stevenson Award of Canada. He is the recipient of the Oregon State Award for Discovery, the Media Award of the American College of Neuropsychopharmacology and was named a distinguished Alumnus of Baylor College of Medicine in 2012. Conn is a previous member of Council for the American Society for Cell Biology and the Endocrine Society and is a prior President of the Endocrine Society, during which time he founded the Hormone Foundation and worked with political leadership to heighten the public’s awareness of diabetes. Conn’s students and fellows have gone on to become leaders in industry and academia. He is an elected member of the Mexican Institute of Medicine and a fellow of the American Association for the Advancement of Science. He is the co-author of The Animal Research War (2008) and many articles for the public and academic community on the value of animal research and the dangers posed by animal extremism. His op/eds have appeared in The Washington Post, The LA Times, The Wall Street Journal, the Des Moines Register, and elsewhere. Conn consults with organizations that are influenced by animal extremism and with universities and companies facing challenges from these groups.

Affiliations and Expertise

Senior Vice President for Research and Associate Provost, Texas Tech Health Sciences Center, TX, USA

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