This new volume of Current Topics in Developmental Biology covers recent progresses in our understanding of animal metamorphosis. Over a dozen of leading experts reviews studies ranging from morphological, molecular to genetic analyses of metamorphosis in a broad spectrum of animals, including insects, fish. Topics include molecular evolution in metamorphosis, the synthesis and function of hormones in regulating metamorphic timing and rate, regulation and function of nuclear hormone receptors, neuroendocrine control of metamorphosis, tissue specific metamorphic events such as autophagy and stem cell development, and applications of genome-wide analysis technologies for studying metamorphosis.

Key Features

  • First comprehensive review of the metamorphosis in diverse animal species by leading experts in the field
  • Covers a broad range of subjects: from morphological changes, molecular and genetic studies, to cutting-edge technologies for metamorphic studies; from systematic changes to tissue specific events, such as autophagy and stem cell development, which are areas of enormous interest in contemporary biomedical research
  • Serves as a reference book for undergraduate and graduate students in fields across biology and biomedicine


Researchers in cell, developmental, and molecular biology; genetics

Table of Contents

Series Page



Chapter One. Developmental Checkpoints and Feedback Circuits Time Insect Maturation

1 Introduction

2 Checkpoint Controls for Progression of Development

3 Signals Converging on the PG

4 Shaping Discrete Ecdysone Pulses

5 Summary and Perspectives


Chapter Two. What Goes Up Must Come Down

1 Introduction

2 Historical Perspective

3 The Ecdysone Hierarchy I: Hormone Action at the Onset of Metamorphosis

4 The Ecdysone Hierarchy II: Early Response Genes

5 The Ecdysone Hierarchy III: Early-Late Response Genes and βftz-f1

6 Upstream of the Hormone: Ecdysone Synthesis in the Prothoracic Glands

7 Role Reversal: The Ecdysone Hierarchy Regulates Its Own Hormone

8 broad Controls a Key Component of Cellular Cholesterol Transport

9 DHR4 is a Key Mediator of PTTH Signaling

10 DHR3/E75-Mediated NO Signaling Is a Critical Player of Ecdysteroidogenesis

11 Other Transcription Factors with Known Expression in the Prothoracic Gland


Chapter Three. Hormonal Regulation of Insect Metamorphosis with Special Reference to Juvenile Hormone Biosynthesis

1 Introduction

2 Regulation of JH Biosynthesis

3 Molecular Action of JH on Insect Molting and Metamorphosis

4 Conclusion


Note Added in Proof

Chapter Four. The Role of Autophagy in Drosophila Metamorphosis

1 Introduction

2 Autophagy

3 Drosophila as a Model for Studying the Interface Between Steroid Signaling, Nutrition, and Growth During Development

4 Autophagy and Drosophila Development

5 Conclusions


Chapter Five. Metamorphosis in Teleosts

1 Introduction and Definitions

2 Metamorphic Diversity in Teleosts

3 Endocrine Controls of Teleost Metamorphosis


No. of pages:
© 2013
Academic Press
Print ISBN:
Electronic ISBN:


"Articles are concisely written and contain clear diagrams...each article has an abstract and is completed by an extensive bibliography, which also is a rich source of information for those interested in this promising complex of themes that are also of relevance for biomedical research."--Entomologie heute,Nov 01 2014