An Invitation to Biomathematics

1st Edition


  • Raina Robeva
  • James Kirkwood
  • Robin Davies
  • Leon Farhy
  • Boris Kovatchev
  • Martin Straume
  • Michael Johnson
  • An Invitation to Biomathematics

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    Essential for all biology and biomathematics courses, this textbook provides students with a fresh perspective of quantitative techniques in biology in a field where virtually any advance in the life sciences requires a sophisticated mathematical approach. An Invitation to Biomathematics, expertly written by a team of experienced educators, offers students a solid understanding of solving biological problems with mathematical applications. This text succeeds in enabling students to truly experience advancements made in biology through mathematical models by containing computer-based hands-on laboratory projects with emphasis on model development, model validation, and model refinement. The supplementary work, Laboratory Manual of Biomathematics is available separately ISBN 0123740223, or as a set ISBN: 0123740290)

    Key Features

    * Provides a complete guide for development of quantification skills crucial for applying mathematical methods to biological problems * Includes well-known examples from across disciplines in the life sciences including modern biomedical research * Explains how to use data sets or dynamical processes to build mathematical models * Offers extensive illustrative materials * Written in clear and easy-to-follow language without assuming a background in math or biology * A laboratory manual is available for hands-on, computer-assisted projects based on material covered in the text


    This textbook is intended for use within courses in mathematical biology, as well as in general mathematics and biology courses that cover the application of math and statistics to biological problems. The reader is not expected to have any extensive background in either math or biology.

    Table of Contents

    1. Processes that Change with Time: Introduction to Dynamical Systems / 2. Complex Dynamics Emerging from Interacting Dynamical Systems / 3. Mathematics in Genetics / 4. Quantitative Genetics and Statistics / 5. Risk Analysis of Blood Glucose Data / 6. Predicting Septicemia in Neonates / 7. Cooperative Binding: How Your Blood Transports Oxygen / 8. Ligand Binding, Data Fitting, and Least-Squares Estimates of Model Parameters / 9. Endocrinology and Hormone Pulsatility / 10. Endocrine Network Modeling: Feedback Loops and Hormone Oscillations / 11. Detecting Rhythms in Confounded Data / 12. Using Microarrays to Study Gene Expression Patterns


    No. of pages:
    © 2008
    Academic Press
    Print ISBN:
    Electronic ISBN:

    About the authors

    Raina Robeva

    Raina Robeva was born in Sofia, Bulgaria. She has a PhD in Mathematics from the University of Virginia and has led multiple NSF-funded curriculum development projects at the interface of mathematics and biology. She is the lead author of the textbook An Invitation to Biomathematics (2008) and the lead editor of the volume Mathematical Concepts and Methods in Modern Biology: Using Modern Discrete Models (2013), both published by Academic Press. Robeva is the founding Chief Editor of the research journal Frontiers in Systems Biology. She is a professor of Mathematical Sciences at Sweet Briar College and lives in Charlottesville, Virginia.

    Affiliations and Expertise

    Professor of Mathematical Sciences, Sweet Briar College, Sweet Briar, VA, USA

    James Kirkwood

    Affiliations and Expertise

    Sweet Briar College, Virginia, U.S.A.

    Robin Davies

    Affiliations and Expertise

    Sweet Briar College, Virginia, U.S.A.

    Boris Kovatchev

    Affiliations and Expertise

    UVA Health System, U.S.A.

    Martin Straume

    Affiliations and Expertise

    University of Virginia, Center for Biomathematical Technology, U.S.A.

    Michael Johnson

    Affiliations and Expertise

    University of Virginia Health Sciences Center, Charlottesville, USA


    “I was impressed with the excellent job done by the authors…particularly, how the biology is explained first and then the math necessary to solve the problem is developed.” --Phil Ryan, Truman State University “I would strongly recommend publication. This book will show young biologists how their existing mathematical skills can be put to powerful use in modern biology.“ --Martin Steward, University of Manchester