An Introduction to Interdisciplinary Toxicology

Interdisciplinary Toxicology: From Molecules to Man provides a thorough exploration of the myriad field of toxicology. Toxicology has developed as an interdisciplinary field, and today’s world presents more complex toxicological problems than ever before, requiring expertise from various disciplines including environmental science, physiology, pharmacology, ecology and others. Importantly, technology and analytical/diagnostic/computational tools have expanded greatly, allowing for more sophisticated experimental approaches and requiring the evaluation of unprecedented amounts of data. Interdisciplinary Toxicology: From Molecules to Man integrates the various aspects of toxicology from “simple” molecular systems to complex human communities, with expertise from a spectrum of interacting disciplines.

Chapters are written by specialists within a subject, such as a chemical engineer, nutritional scientist, or a microbiologist, so that these subjects are clearly explained and discussed within the toxicology context. Many chapters are comparative across species so that students in ecotoxicology learn mammalian toxicology and vice versa. Specific citations, further reading, study questions, and other learning features are included. Interdisciplinary Toxicology: From Molecules to Man allows students to learn concepts in both biomedical and environmental toxicology fields concurrently, better equipping them for the many career opportunities toxicology provides. This book will also be useful to those wishing to reference how disciplines interact within the broad field of toxicology.

• Covers major topics and newer areas in toxicology including nanotoxicology, Tox21, epigenetic toxicology, and organ-specific toxicity.
• Includes a variety of perspectives to give a complete understanding of toxicology.
• Written by specialists within subject areas, e.g., a chemical engineer, to ensure concepts are clearly explained.

Graduate students and advanced undergraduate students in toxicology programs. Students and researchers in medicine, environmental sciences, neuroscience, food sciences, computing, and fundamental life sciences needing information about toxicology information in their discipline

I. General Concepts
1. Principles
2. Sources of exposures: Point vs Nonpoint Source Contamination
3. How chemicals distribute in the physical environment
4. How chemicals distribute in cells and simple organisms
5. How chemicals distribute in complex organisms

II. Responses to chemical toxicants
6. Cellular responses to toxicants
7. Genotoxicity and epigenetics
8. Carcinogenesis
9. Disruption of cell signaling
10. Altered development and reproduction
11. Microbiome alterations and modulation of toxicity
12. Nanotoxicology

III. Organ System Effects
13. Dermal system
14. Gastrointestinal system
15. Excretory system
16. Respiratory System
17. Cardiovascular system
18. Musculoskeletal system
19. Endocrine system
20. The immune system
21. Visual system
22. Nervous system

IV. Ecosystems and Ecotoxicology
23. Organism vs population
24. Bioconcentration
25. Biomarkers

V. Toxicology in the Home
26. Opiates and other therapeutics
27. Cleaning products
28. Petroleum products

VI. Toxicology in the Community
29. Historical case studies
30. Social factors in community contamination

VII. Forensic Toxicology

VIII. Regulatory Toxicology
31. Toxicity testing
32. Tox21
33. Principles of Risk Assessment

IX. Reference materials and websites
34. Information Resources in Toxicology, 4th edition.
35. National Toxicology Program
36. National Center for Toxicological Research
37. FDA
38. EPA