Aminopyridines and Similarly Acting Drugs: Effects on Nerves, Muscles and Synapses

1st Edition

Proceedings of a IUPHAR Satellite Symposium in Conjunction with the 8th International Congress of Pharmacology, Paris, France, July 27-29, 1981

Authors:

  • P. Lechat
  • S. Thesleff
  • W. C. Bowman
  • Description

    Aminopyridines and Similarly Acting Drugs: Effects on Nerves, Muscles and Synapses presents the proceedings of a IUPHAR Satellite Symposium in conjunction with the eighth International Congress of Pharmacology held in Paris, France on July 27-29, 1981. The book contains papers on the effects of aminopyridines on ionic currents in excitable membranes; the effects of aminopyridines on synaptic transmission; and the effects of aminopyridines on the release of chemical transmitters. The text also presents papers on some differences in the blockade of potassium permeabilities by apamin and the aminopyridines; the miscellaneous actions of aminopyridines and related compounds; and the effects of aminopyridines on the skeletal, smooth and cardiac muscle. The clinical applications of aminopyridines and further miscellaneous actions of aminopyridines and related compounds are also considered.

    Table of Contents


    List of Participants

    Scientific Sessions

    Historical review

    Aminopyridines and Ionic Currents in Excitable Memebranes

    General review on potassium currents in exitable membranes of nerve and muscle

    Effects of Aminopyridines on Potassium currents of the Nodal Membrane

    Properties and Physiological Roles of K+ Currents in Frog Myelinated Nerve Fibres as Revealed by 4-aminopyridine

    Effects of Aminopyridines on Ionic Currents and Ionic Channel Noise in Unrnyelinated Axons

    3- and 4-Aminopyridine in Synaptic Transmission at the Squid Giant Synapse

    Discussion

    Aminopyridines and Synaptic Transmission

    Lectures

    General Principles of Synaptic Transmission

    Effects of Aminopyridines on Neuromuscular Transmission

    Effects of 4-Aminopyridine on Transmission in Excitatory and Inhibitory synapses in the spinal cord

    The Influence of 4-Aminopyridine on Parasympathetic Transmission

    Discussion

    Aminopyridines and the Release of Chemical Transmitters: Contrast with Apamin

    Lectures

    Structure-Activity Relationships Amongst Aminopyridines

    Aminopyridine as a tool to Investigate the Mechanism of Acetylcholine Release at the Nerve Electroplaque Junction

    Intramembrane Particles Changes: A Constant Feature of the Release Mechanism

    Effect of Aminopyridine and Related Drugs on Catecholamine Release

    Some Differences in the Blockade of Potassium Permeabilities by Apamin and the Aminopyridines

    Discussion

    Miscellaneous Actions of Aminopyridines and Related Compounds: Poster Communications

    The action of Morphine Dependence on the Convulsive Effect of 4-Aminopyridine and Other Drugs

    Antagonism to Dopaminergic Stereotypy, and Convulsant and Hypertensive Effects by

    Details

    No. of pages:
    362
    Language:
    English
    Copyright:
    © 1982
    Published:
    Imprint:
    Pergamon
    Print ISBN:
    9780080280004
    Electronic ISBN:
    9781483150437