Aminopyridines and Similarly Acting Drugs: Effects on Nerves, Muscles and Synapses

1st Edition

Proceedings of a IUPHAR Satellite Symposium in Conjunction with the 8th International Congress of Pharmacology, Paris, France, July 27-29, 1981

Editors: P. Lechat S. Thesleff W. C. Bowman
Hardcover ISBN: 9780080280004
eBook ISBN: 9781483150437
Imprint: Pergamon
Published Date: 29th April 1982
Page Count: 362
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Description

Aminopyridines and Similarly Acting Drugs: Effects on Nerves, Muscles and Synapses presents the proceedings of a IUPHAR Satellite Symposium in conjunction with the eighth International Congress of Pharmacology held in Paris, France on July 27-29, 1981. The book contains papers on the effects of aminopyridines on ionic currents in excitable membranes; the effects of aminopyridines on synaptic transmission; and the effects of aminopyridines on the release of chemical transmitters. The text also presents papers on some differences in the blockade of potassium permeabilities by apamin and the aminopyridines; the miscellaneous actions of aminopyridines and related compounds; and the effects of aminopyridines on the skeletal, smooth and cardiac muscle. The clinical applications of aminopyridines and further miscellaneous actions of aminopyridines and related compounds are also considered.

Table of Contents


List of Participants


Scientific Sessions


Historical review


Aminopyridines and Ionic Currents in Excitable Memebranes


General review on potassium currents in exitable membranes of nerve and muscle


Effects of Aminopyridines on Potassium currents of the Nodal Membrane


Properties and Physiological Roles of K+ Currents in Frog Myelinated Nerve Fibres as Revealed by 4-aminopyridine


Effects of Aminopyridines on Ionic Currents and Ionic Channel Noise in Unrnyelinated Axons


3- and 4-Aminopyridine in Synaptic Transmission at the Squid Giant Synapse


Discussion


Aminopyridines and Synaptic Transmission


Lectures


General Principles of Synaptic Transmission


Effects of Aminopyridines on Neuromuscular Transmission


Effects of 4-Aminopyridine on Transmission in Excitatory and Inhibitory synapses in the spinal cord


The Influence of 4-Aminopyridine on Parasympathetic Transmission


Discussion


Aminopyridines and the Release of Chemical Transmitters: Contrast with Apamin


Lectures


Structure-Activity Relationships Amongst Aminopyridines


Aminopyridine as a tool to Investigate the Mechanism of Acetylcholine Release at the Nerve Electroplaque Junction


Intramembrane Particles Changes: A Constant Feature of the Release Mechanism


Effect of Aminopyridine and Related Drugs on Catecholamine Release


Some Differences in the Blockade of Potassium Permeabilities by Apamin and the Aminopyridines


Discussion


Miscellaneous Actions of Aminopyridines and Related Compounds: Poster Communications


The action of Morphine Dependence on the Convulsive Effect of 4-Aminopyridine and Other Drugs


Antagonism to Dopaminergic Stereotypy, and Convulsant and Hypertensive Effects by

Details

No. of pages:
362
Language:
English
Copyright:
© Pergamon 1982
Published:
Imprint:
Pergamon
eBook ISBN:
9781483150437
Hardcover ISBN:
9780080280004

About the Editor

P. Lechat

S. Thesleff

W. C. Bowman