Aminopyridines and Similarly Acting Drugs: Effects on Nerves, Muscles and Synapses

1st Edition

Proceedings of a IUPHAR Satellite Symposium in Conjunction with the 8th International Congress of Pharmacology, Paris, France, July 27-29, 1981

Editors:

Description

Aminopyridines and Similarly Acting Drugs: Effects on Nerves, Muscles and Synapses presents the proceedings of a IUPHAR Satellite Symposium in conjunction with the eighth International Congress of Pharmacology held in Paris, France on July 27-29, 1981. The book contains papers on the effects of aminopyridines on ionic currents in excitable membranes; the effects of aminopyridines on synaptic transmission; and the effects of aminopyridines on the release of chemical transmitters. The text also presents papers on some differences in the blockade of potassium permeabilities by apamin and the aminopyridines; the miscellaneous actions of aminopyridines and related compounds; and the effects of aminopyridines on the skeletal, smooth and cardiac muscle. The clinical applications of aminopyridines and further miscellaneous actions of aminopyridines and related compounds are also considered.

Table of Contents


List of Participants

Scientific Sessions

Historical review

Aminopyridines and Ionic Currents in Excitable Memebranes

General review on potassium currents in exitable membranes of nerve and muscle

Effects of Aminopyridines on Potassium currents of the Nodal Membrane

Properties and Physiological Roles of K+ Currents in Frog Myelinated Nerve Fibres as Revealed by 4-aminopyridine

Effects of Aminopyridines on Ionic Currents and Ionic Channel Noise in Unrnyelinated Axons

3- and 4-Aminopyridine in Synaptic Transmission at the Squid Giant Synapse

Discussion

Aminopyridines and Synaptic Transmission

Lectures

General Principles of Synaptic Transmission

Effects of Aminopyridines on Neuromuscular Transmission

Effects of 4-Aminopyridine on Transmission in Excitatory and Inhibitory synapses in the spinal cord

The Influence of 4-Aminopyridine on Parasympathetic Transmission

Discussion

Aminopyridines and the Release of Chemical Transmitters: Contrast with Apamin

Lectures

Structure-Activity Relationships Amongst Aminopyridines

Aminopyridine as a tool to Investigate the Mechanism of Acetylcholine Release at the Nerve Electroplaque Junction

Intramembrane Particles Changes: A Constant Feature of the Release Mechanism

Effect of Aminopyridine and Related Drugs on Catecholamine Release

Some Differences in the Blockade of Potassium Permeabilities by Apamin and the Aminopyridines

Discussion

Miscellaneous Actions of Aminopyridines and Related Compounds: Poster Communications

The action of Morphine Dependence on the Convulsive Effect of 4-Aminopyridine and Other Drugs

Antagonism to Dopaminergic Stereotypy, and Convulsant and Hypertensive Effects by

Details

No. of pages:
362
Language:
English
Copyright:
© 1982
Published:
Imprint:
Pergamon
Electronic ISBN:
9781483150437
Print ISBN:
9780080280004

About the editors